Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | frizzled | 0.0085 | 0.0159 | 0.0159 |
Echinococcus multilocularis | smoothened | 0.1892 | 1 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0085 | 0.0159 | 0.0181 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0014 | 0.0016 |
Loa Loa (eye worm) | MBCTL1 | 0.0064 | 0.0042 | 0.0043 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0069 | 0.0071 | 0.0071 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0221 | 0.0897 | 0.0897 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0085 | 0.0159 | 0.0163 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0221 | 0.0897 | 0.0897 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0069 | 0.0071 | 0.0081 |
Echinococcus granulosus | frizzled | 0.0085 | 0.0159 | 0.0159 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1672 | 0.8799 | 0.5 |
Echinococcus granulosus | frizzled | 0.0085 | 0.0159 | 0.0159 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0085 | 0.0159 | 0.0181 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0064 | 0.0042 | 0.0042 |
Schistosoma mansoni | frizzled | 0.0085 | 0.0159 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.1672 | 0.8799 | 0.8991 |
Brugia malayi | jmjC domain containing protein | 0.0069 | 0.0071 | 0.0081 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0069 | 0.0071 | 0.0081 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1507 | 0.7899 | 0.7899 |
Schistosoma mansoni | frizzled-like receptor | 0.0085 | 0.0159 | 0.0181 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0069 | 0.0071 | 0.0073 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0165 | 0.0595 | 0.0676 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.1672 | 0.8799 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1672 | 0.8799 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0069 | 0.0071 | 0.0071 |
Echinococcus granulosus | lysosomal protective protein | 0.1672 | 0.8799 | 0.8799 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1672 | 0.8799 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0042 | 0.0043 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0069 | 0.0071 | 0.0071 |
Echinococcus multilocularis | frizzled 4 | 0.0085 | 0.0159 | 0.0159 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.1672 | 0.8799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0014 | 0.0014 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.1672 | 0.8799 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.1672 | 0.8799 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0064 | 0.0042 | 0.0042 |
Echinococcus multilocularis | lysosomal protective protein | 0.1672 | 0.8799 | 0.8799 |
Loa Loa (eye worm) | hypothetical protein | 0.1853 | 0.9787 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1672 | 0.8799 | 0.5 |
Echinococcus granulosus | frizzled 5 | 0.0085 | 0.0159 | 0.0159 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0064 | 0.0042 | 0.0048 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0085 | 0.0159 | 0.0181 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0014 | 0.0016 |
Schistosoma mansoni | jumonji domain containing protein | 0.0069 | 0.0071 | 0.0081 |
Echinococcus granulosus | frizzled | 0.0085 | 0.0159 | 0.0159 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.1672 | 0.8799 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1672 | 0.8799 | 0.5 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0064 | 0.0042 | 0.0042 |
Echinococcus multilocularis | frizzled | 0.0085 | 0.0159 | 0.0159 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0064 | 0.0042 | 0.0048 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1672 | 0.8799 | 0.5 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0085 | 0.0159 | 0.0163 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1672 | 0.8799 | 0.5 |
Echinococcus multilocularis | frizzled 5 | 0.0085 | 0.0159 | 0.0159 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0069 | 0.0071 | 0.0071 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0064 | 0.0042 | 0.0042 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1507 | 0.7899 | 0.7899 |
Echinococcus granulosus | frizzled 4 | 0.0085 | 0.0159 | 0.0159 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.155 | 0.1761 |
Brugia malayi | jmjC domain containing protein | 0.0069 | 0.0071 | 0.0081 |
Echinococcus multilocularis | frizzled 10 | 0.0085 | 0.0159 | 0.0159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.