Detailed information for compound 586060

Basic information

Technical information
  • TDR Targets ID: 586060
  • Name: 5-acetyl-3-amino-1,4-dioxo-naphthalene-2-carb oxamide
  • MW: 258.229 | Formula: C13H10N2O4
  • H donors: 2 H acceptors: 4 LogP: 0.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1=C(N)C(=O)c2c(C1=O)cccc2C(=O)C
  • InChi: 1S/C13H10N2O4/c1-5(16)6-3-2-4-7-8(6)12(18)10(14)9(11(7)17)13(15)19/h2-4H,14H2,1H3,(H2,15,19)
  • InChiKey: GEZOTJVKGITFJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-acetyl-3-amino-1,4-dioxo-2-naphthalenecarboxamide
  • 3-azanyl-5-ethanoyl-1,4-dioxo-naphthalene-2-carboxamide
  • 5-acetyl-3-amino-1,4-diketo-2-naphthamide
  • 5-acetyl-3-amino-1,4-dioxonaphthalene-2-carboxamide
  • sarubicin B
  • 3-amino-5-ethanoyl-1,4-dioxo-naphthalene-2-carboxamide
  • 84745-01-7
  • 2-Naphthalenecarboxamide, 5-acetyl-3-amino-1,4-dihydro-1,4-dioxo-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1815 0.8335 1
Echinococcus multilocularis regulator of G protein signaling 0.0351 0.1395 0.1674
Schistosoma mansoni serine/threonine protein kinase 0.2166 1 1
Schistosoma mansoni axis inhibition protein axin 0.0351 0.1395 0.1395
Echinococcus granulosus plexin a4 0.015 0.0439 0.0527
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2166 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0065 0.0037 0.0037
Echinococcus granulosus axis inhibition protein axin 0.0351 0.1395 0.1674
Echinococcus granulosus axis inhibition protein axin 0.0351 0.1395 0.1674
Echinococcus multilocularis regulator of G protein signaling 3 0.0351 0.1395 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Entamoeba histolytica hypothetical protein 0.0351 0.1395 1
Toxoplasma gondii aurora kinase 0.0061 0.0018 0.5
Schistosoma mansoni serine/threonine protein kinase 0.166 0.7602 0.7602
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0018 0.0018
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0061 0.0018 0.5
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0351 0.1395 0.1674
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Schistosoma mansoni regulator of G protein signaling 0.0351 0.1395 0.1395
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1815 0.8335 0.8335
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1815 0.8335 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0061 0.0018 0.0022
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1815 0.8335 0.8335
Echinococcus multilocularis beta adrenergic receptor kinase 0.166 0.7602 0.9121
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0351 0.1395 0.1395
Loa Loa (eye worm) hypothetical protein 0.0125 0.0321 0.0321
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0018 0.0018
Echinococcus multilocularis plexin a4 0.015 0.0439 0.0527
Echinococcus multilocularis axis inhibition protein axin 0.0351 0.1395 0.1674
Schistosoma mansoni regulator of G protein signaling 0.0351 0.1395 0.1395
Entamoeba histolytica hypothetical protein 0.0351 0.1395 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0061 0.0018 0.0022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0351 0.1395 0.1395
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0351 0.1395 0.1395
Echinococcus multilocularis regulator of G protein signaling 3 0.0351 0.1395 0.1674
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1815 0.8335 0.8335
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0018 0.0018
Onchocerca volvulus 0.0125 0.0321 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0351 0.1395 0.1395
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Echinococcus granulosus twitchin 0.0062 0.0024 0.0029
Trypanosoma brucei aurora B kinase 0.0061 0.0018 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Schistosoma mansoni plexin 0.0068 0.0051 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0351 0.1395 0.1395
Schistosoma mansoni hypothetical protein 0.0068 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0351 0.1395 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0351 0.1395 0.1674
Brugia malayi serine/threonine kinase 12 0.0061 0.0018 0.0018
Brugia malayi Plexin repeat family protein 0.0125 0.0321 0.0321
Echinococcus granulosus beta-adrenergic receptor kinase 0.166 0.7602 0.9121
Trypanosoma cruzi aurora B kinase, putative 0.0061 0.0018 0.5
Schistosoma mansoni z-protein (S1r protein) 0.0351 0.1395 0.1395
Echinococcus granulosus expressed protein 0.0351 0.1395 0.1674
Echinococcus multilocularis axis inhibition protein axin 0.0351 0.1395 0.1674
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0351 0.1395 1
Echinococcus multilocularis aurora kinase A 0.0061 0.0018 0.0022
Schistosoma mansoni plexin 0.0125 0.0321 0.0321
Loa Loa (eye worm) plexin A 0.015 0.0439 0.0439
Loa Loa (eye worm) PXA domain-containing protein 0.0351 0.1395 0.1395
Brugia malayi PXA domain containing protein 0.0351 0.1395 0.1395
Echinococcus granulosus G protein coupled receptor kinase 1 0.1309 0.5937 0.7123
Loa Loa (eye worm) RGS-3 protein 0.0351 0.1395 0.1395
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0018 0.0018
Echinococcus granulosus Regulator of G protein signaling 20 0.0351 0.1395 0.1674
Schistosoma mansoni protein kinase 0.0061 0.0018 0.0018
Brugia malayi hypothetical protein 0.0351 0.1395 0.1395
Echinococcus granulosus regulator of G protein signaling 7 0.0351 0.1395 0.1674
Giardia lamblia Aurora kinase 0.0061 0.0018 0.5
Brugia malayi plexin A 0.015 0.0439 0.0439
Brugia malayi serine/threonine protein kinase 6 0.0061 0.0018 0.0018
Echinococcus granulosus regulator of G protein signaling 3 0.0351 0.1395 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Brugia malayi PXA domain containing protein 0.0351 0.1395 0.1395
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0351 0.1395 0.1395
Schistosoma mansoni regulator of G protein signaling 0.0351 0.1395 0.1395
Schistosoma mansoni axis inhibition protein axin 0.0351 0.1395 0.1395
Trichomonas vaginalis conserved hypothetical protein 0.0351 0.1395 1
Echinococcus granulosus aurora kinase A 0.0061 0.0018 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.166 0.7602 0.7602
Echinococcus granulosus regulator of G protein signaling 7 0.0351 0.1395 0.1674
Brugia malayi hypothetical protein 0.0351 0.1395 0.1395
Plasmodium falciparum serine/threonine protein kinase, putative 0.0061 0.0018 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0051 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.0037 0.0037
Echinococcus granulosus regulator of G protein signaling 3 0.0351 0.1395 0.1674
Brugia malayi regulator of G-protein signaling rgs-7 0.0351 0.1395 0.1395
Brugia malayi serine/threonine-protein kinase 6 0.0061 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0351 0.1395 0.1395
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0351 0.1395 0.1395
Schistosoma mansoni regulator of G protein signaling 0.0351 0.1395 0.1395
Echinococcus multilocularis Regulator of G protein signaling 20 0.0351 0.1395 0.1674
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.166 0.7602 0.7602
Brugia malayi A-kinase anchor protein 10, precursor 0.0351 0.1395 0.1395
Brugia malayi regulator of G-protein signaling egl-10 0.0351 0.1395 0.1395
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0351 0.1395 0.1674
Echinococcus multilocularis expressed protein 0.0351 0.1395 0.1674
Echinococcus multilocularis regulator of G protein signaling 7 0.0351 0.1395 0.1674
Leishmania major protein kinase, putative 0.0061 0.0018 0.5
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1309 0.5937 0.7123

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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