Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0025 | 0.0593 | 0.0226 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0177 | 0.0184 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.0841 | 0.4215 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.2454 | 0.2838 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0007 | 0.0081 | 0.0072 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0362 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.8599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.8599 | 1 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0841 | 0.1334 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0177 | 0.0362 |
Echinococcus multilocularis | muscleblind protein | 0.0307 | 0.8599 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0373 | 0.0764 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0841 | 0.1724 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.0841 | 0.1334 |
Mycobacterium tuberculosis | ATP phosphoribosyltransferase HisG | 0.0356 | 1 | 1 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0025 | 0.0593 | 0.0669 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0025 | 0.0593 | 0.0669 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1228 | 0.141 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0841 | 0.0958 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0177 | 0.1917 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0177 | 0.0362 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0362 |
Loa Loa (eye worm) | pyruvate kinase | 0.0007 | 0.0081 | 0.0072 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0177 | 0.1917 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Muscleblind-like protein | 0.0307 | 0.8599 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1228 | 0.141 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0177 | 0.0362 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0025 | 0.0593 | 0.47 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0019 | 0.0039 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Echinococcus granulosus | dual specificity | 0.0091 | 0.2454 | 0.2838 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.0841 | 0.0958 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0774 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.094 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.055 | 0.0619 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1228 | 0.141 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.1676 | 0.3435 |
Echinococcus granulosus | geminin | 0.0176 | 0.488 | 0.5665 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0091 | 0.2454 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0036 | 0.002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0081 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.488 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0177 | 0.0362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0184 |
Onchocerca volvulus | 0.003 | 0.0726 | 0.8599 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0177 | 0.0362 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0141 | 0.0142 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.2454 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0593 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.094 | 0.1074 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0774 | 0.088 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0025 | 0.0593 | 0.6778 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2441 | 0.2823 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0726 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0184 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Mycobacterium ulcerans | ATP phosphoribosyltransferase | 0.0356 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1228 | 0.141 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.094 | 0.1074 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0036 | 0.002 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0137 | 0.0138 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0019 | 0.0039 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0307 | 0.8599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0177 | 0.1917 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0593 | 0.0669 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | hypothetical protein | 0.0037 | 0.094 | 0.1074 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0019 | 0.0039 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0036 | 0.002 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0726 | 0.1488 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0177 | 0.0184 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2441 | 0.2823 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0089 | 0.0081 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1228 | 0.141 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.2454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0841 | 0.1334 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | muscleblind protein | 0.0307 | 0.8599 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0177 | 0.0184 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.0841 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2454 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | geminin | 0.0176 | 0.488 | 0.5665 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0025 | 0.0593 | 0.47 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0141 | 0.0142 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0019 | 0.0039 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Brugia malayi | pyruvate kinase | 0.0007 | 0.0081 | 0.0072 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.001 | 0.017 | 0.0176 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.2454 | 0.503 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0089 | 0.0081 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0841 | 0.1334 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0774 | 0.1587 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.055 | 0.0619 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0182 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0036 | 0.0074 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.0841 | 0.1334 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0638 | 0.0722 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0177 | 0.0362 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0141 | 0.0142 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0019 | 0.0039 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.488 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0184 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0025 | 0.0593 | 0.1981 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0081 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0019 | 0.0039 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0726 | 0.0824 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0036 | 0.0074 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0177 | 0.0362 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0091 | 0.2454 | 0.2838 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.1484 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0025 | 0.0593 | 0.0669 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.0841 | 0.5 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0025 | 0.0593 | 0.47 |
Trichomonas vaginalis | chaperonin, putative | 0.0025 | 0.0593 | 0.6778 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0019 | 0.0039 |
Echinococcus multilocularis | dual specificity | 0.0091 | 0.2454 | 0.2838 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0841 | 1 |
Onchocerca volvulus | 0.001 | 0.0177 | 0.1917 | |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0841 | 0.1724 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.094 | 0.1927 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0774 | 0.1587 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0019 | 0.0039 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1228 | 0.141 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.2454 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0841 | 0.1334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.