Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0593 | 0.0669 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0184 |
Trichomonas vaginalis | chaperonin, putative | 0.0025 | 0.0593 | 0.6778 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1228 | 0.141 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.1676 | 0.3435 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0726 | 0.0824 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1228 | 0.141 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0019 | 0.0039 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.001 | 0.017 | 0.0176 |
Mycobacterium tuberculosis | ATP phosphoribosyltransferase HisG | 0.0356 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0177 | 0.0184 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0089 | 0.0081 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0177 | 0.0362 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.094 | 0.1074 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0177 | 0.0362 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0025 | 0.0593 | 0.1981 |
Echinococcus multilocularis | geminin | 0.0176 | 0.488 | 0.5665 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.2454 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0177 | 0.1917 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | muscleblind protein | 0.0307 | 0.8599 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0019 | 0.0039 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.0007 | 0.0081 | 0.0072 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0362 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0019 | 0.0039 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0638 | 0.0722 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0137 | 0.0138 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0726 | 0.0824 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0841 | 0.1334 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0036 | 0.0074 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2441 | 0.2823 |
Loa Loa (eye worm) | pyruvate kinase | 0.0007 | 0.0081 | 0.0072 |
Echinococcus multilocularis | dual specificity | 0.0091 | 0.2454 | 0.2838 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0177 | 0.0184 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0025 | 0.0593 | 0.6778 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0019 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.2454 | 0.2838 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0025 | 0.0593 | 0.0669 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.0841 | 0.4215 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0081 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0036 | 0.002 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.0841 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.055 | 0.0619 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0774 | 0.088 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0177 | 0.0362 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0091 | 0.2454 | 1 |
Onchocerca volvulus | 0.001 | 0.0177 | 0.1917 | |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0307 | 0.8599 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0841 | 0.1724 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0177 | 0.0362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1228 | 0.2518 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0019 | 0.0039 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Muscleblind-like protein | 0.0307 | 0.8599 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.0841 | 0.1334 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0182 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0019 | 0.0039 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0177 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0089 | 0.0081 |
Brugia malayi | hypothetical protein | 0.0037 | 0.094 | 0.1074 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | dual specificity | 0.0091 | 0.2454 | 0.2838 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0841 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.055 | 0.0619 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.1484 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0025 | 0.0593 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0841 | 0.0958 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1228 | 0.141 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0774 | 0.088 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1228 | 0.141 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0141 | 0.0142 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0774 | 0.1587 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0841 | 0.1334 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2454 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.0841 | 0.0958 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0019 | 0.0039 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0141 | 0.0142 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1228 | 0.141 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.488 | 1 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0025 | 0.0593 | 0.47 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.8599 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0177 | 0.0362 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0177 | 0.0184 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0841 | 0.1334 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0177 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.094 | 0.1927 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0177 | 0.1917 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0177 | 0.0362 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | geminin | 0.0176 | 0.488 | 0.5665 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0184 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0025 | 0.0593 | 0.0669 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0025 | 0.0593 | 0.0669 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0177 | 0.0362 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0177 | 0.0184 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0841 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0177 | 0.0184 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0091 | 0.2454 | 0.2838 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0841 | 0.1334 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0177 | 0.0362 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0177 | 0.1917 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0177 | 0.0184 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.0841 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0177 | 0.0184 |
Echinococcus granulosus | muscleblind protein | 0.0307 | 0.8599 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.0841 | 0.1334 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.8599 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0593 | 0.0669 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.094 | 0.205 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0373 | 0.0412 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0089 | 0.0081 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0025 | 0.0593 | 0.47 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0177 | 0.0184 |
Mycobacterium ulcerans | ATP phosphoribosyltransferase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0841 | 0.0958 |
Brugia malayi | pyruvate kinase | 0.0007 | 0.0081 | 0.0072 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0091 | 0.2454 | 1 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0025 | 0.0593 | 0.47 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0177 | 0.0362 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0774 | 0.1587 |
Onchocerca volvulus | 0.003 | 0.0726 | 0.8599 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0036 | 0.0074 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.094 | 0.1074 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0177 | 0.0184 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.2454 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.094 | 0.1927 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0177 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2441 | 0.2823 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0091 | 0.2454 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0373 | 0.0764 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0141 | 0.0142 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1228 | 0.141 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.0841 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0019 | 0.0039 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0593 | 0.1215 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.2454 | 0.503 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0726 | 0.1488 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0177 | 0.0184 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0841 | 0.1724 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0036 | 0.002 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0177 | 0.0184 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.0841 | 0.0958 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0177 | 0.0184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.