Detailed information for compound 587122

Basic information

Technical information
  • TDR Targets ID: 587122
  • Name: (2R)-2-amino-3-[(2,6,7-trimethyl-3,5-dioxo-py razolo[1,2-a]pyrazol-1-yl)methylsulfanyl]prop anoic acid
  • MW: 311.357 | Formula: C13H17N3O4S
  • H donors: 2 H acceptors: 4 LogP: -2.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](CSCc1n2c(C)c(c(=O)n2c(=O)c1C)C)N
  • InChi: 1S/C13H17N3O4S/c1-6-8(3)15-10(5-21-4-9(14)13(19)20)7(2)12(18)16(15)11(6)17/h9H,4-5,14H2,1-3H3,(H,19,20)/t9-/m0/s1
  • InChiKey: NMURTHXSOSFFBJ-VIFPVBQESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-amino-3-[(2,6,7-trimethyl-3,5-dioxo-1-pyrazolo[1,2-a]pyrazolyl)methylthio]propanoic acid
  • (2R)-2-azanyl-3-[(2,6,7-trimethyl-3,5-dioxo-pyrazolo[1,2-a]pyrazol-1-yl)methylsulfanyl]propanoic acid
  • (2R)-2-amino-3-[(3,5-diketo-2,6,7-trimethyl-pyrazolo[1,2-a]pyrazol-1-yl)methylthio]propionic acid
  • (2R)-2-amino-3-[(2,6,7-trimethyl-3,5-dioxopyrazolo[1,2-a]pyrazol-1-yl)methylsulfanyl]propanoic acid
  • S-bimanylcysteine
  • (2R)-2-amino-3-[(3,5-diketo-2,6,7-trimethyl-pyrazolo[2,1-a]pyrazol-1-yl)methylthio]propionic acid
  • 87623-39-0
  • L-Cysteine, S-((2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo(1,2-a)pyrazol-3-yl)methyl)-
  • S-Bimane-L-cysteine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Muscleblind-like protein 0.0157 0.4816 0.4816
Schistosoma mansoni potassium channel beta 0.0092 0.2686 0.2685
Loa Loa (eye worm) hypothetical protein 0.0182 0.5619 0.5619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0798 0.0798
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0798 0.0796
Brugia malayi nuclear receptor NHR-67 0.0016 0.022 0.022
Entamoeba histolytica aldose reductase, putative 0.0316 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Entamoeba histolytica aldose reductase, putative 0.0316 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0316 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0282 0.028
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0092 0.2686 0.2685
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Echinococcus multilocularis muscleblind protein 1 0.0157 0.4816 0.4815
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0282 0.0282
Onchocerca volvulus 0.0016 0.022 0.022
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0035 0.0033
Echinococcus granulosus muscleblind protein 0.0157 0.4816 0.4815
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0065
Giardia lamblia Aldose reductase 0.0316 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.022 0.022
Entamoeba histolytica aldose reductase, putative 0.0316 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0282 0.028
Loa Loa (eye worm) oxidoreductase 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0011 0.0065 0.0064
Onchocerca volvulus 0.0014 0.0153 0.0153
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0316 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0092 0.2686 0.2686
Mycobacterium ulcerans oxidoreductase 0.0316 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1269 0.1268
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0798 0.0796
Echinococcus multilocularis aldo keto reductase 0.0316 1 1
Onchocerca volvulus 0.0316 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Onchocerca volvulus 0.0092 0.2686 0.2686
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1269 0.1269
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0798 0.0796
Echinococcus granulosus voltage gated potassium channel subunit 0.0092 0.2686 0.2685
Onchocerca volvulus 0.0316 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0798 0.0796
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.022 0.0218
Trypanosoma cruzi aldo-keto reductase 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0153
Onchocerca volvulus 0.0025 0.0515 0.0515
Brugia malayi ecdysteroid receptor 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Schistosoma mansoni pol-related 0.0316 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Echinococcus granulosus hypothetical protein 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.4816 0.4816
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.022 0.0218
Loa Loa (eye worm) hypothetical protein 0.0316 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.022 0.022
Brugia malayi steroid hormone receptor 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor E75 0.0016 0.022 0.022
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0316 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0207 0.6435 0.6434
Loa Loa (eye worm) hypothetical protein 0.0157 0.4816 0.4816
Loa Loa (eye worm) hypothetical protein 0.0025 0.0515 0.0515
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0092 0.2686 0.2686
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0798 0.0796
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0798 0.0798
Leishmania major prostaglandin f synthase, putative 0.0316 1 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0009 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0798 0.0796
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.022 0.0218
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0282
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0798 0.0796
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0798 0.0796
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0798 0.0796
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0798 0.0798
Toxoplasma gondii aldose reductase, putative 0.0316 1 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0092 0.2686 0.2289
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0798 0.0798
Onchocerca volvulus 0.0016 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0798 0.0798
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1269 0.1268
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.022 0.0218
Leishmania major aldo-keto reductase-like protein 0.0316 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0316 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0798 0.0798
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0798 0.0796
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.022 0.0218
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0282 0.0282
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0798 0.0796
Echinococcus multilocularis aldo keto reductase 0.0316 1 1
Loa Loa (eye worm) oxidoreductase 0.0316 1 1
Echinococcus multilocularis muscleblind protein 0.0157 0.4816 0.4815
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0798 0.0796
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.022 0.0218
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0515 0.0514
Onchocerca volvulus 0.0011 0.0065 0.0065
Toxoplasma gondii aldo-keto reductase 0.0092 0.2686 0.2289
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0515 0.0515
Brugia malayi Muscle positioning protein 4 0.0014 0.0153 0.0153
Brugia malayi hypothetical protein 0.0016 0.022 0.022
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.022 0.0218
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.022 0.0218
Loa Loa (eye worm) hypothetical protein 0.0207 0.6435 0.6435
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Echinococcus granulosus aldo keto reductase 0.0316 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0798 0.0796
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0798 0.0798
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0798 0.0798
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0798 0.0798
Onchocerca volvulus 0.0316 1 1
Brugia malayi nuclear hormone receptor 0.0016 0.022 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Brugia malayi hypothetical protein 0.0018 0.0282 0.0282
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Loa Loa (eye worm) oxidoreductase 0.0316 1 1
Plasmodium vivax aldehyde reductase, putative 0.0092 0.2686 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0092 0.2686 0.2685
Loa Loa (eye worm) DOMON domain-containing protein 0.0011 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0282 0.028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor E75 0.0016 0.022 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.022 0.0218
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.022 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0798 0.0798
Mycobacterium tuberculosis Probable oxidoreductase 0.0316 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0092 0.2686 1
Onchocerca volvulus 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0025 0.0515 0.0514
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0092 0.2686 0.2289
Echinococcus granulosus aldo keto reductase 0.0316 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0798 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0798 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0798 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0798 0.0798
Brugia malayi conserved hypotetical protein 0.0016 0.022 0.022
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0316 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.022 0.022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.022 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1269 0.1268
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0798 0.0796
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0316 1 1
Schistosoma mansoni aldo-keto reductase 0.0316 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0798 0.0796
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Brugia malayi nuclear receptor RXR 0.0018 0.0282 0.0282
Loa Loa (eye worm) oxidoreductase 0.0316 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0798 0.0798
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0798 0.0796
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0798 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0798 0.0798
Brugia malayi ecdysone receptor 0.0016 0.022 0.022
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.022 0.0218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0798 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1269 0.1268
Brugia malayi hypothetical protein 0.0016 0.022 0.022
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.022 0.0218
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0798 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0798 0.0796
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0092 0.2686 1
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0798 0.0796
Brugia malayi Kringle domain containing protein 0.0025 0.0515 0.0515
Schistosoma mansoni nuclear hormone receptor 0.0016 0.022 0.0218
Schistosoma mansoni nuclear receptor 0.0016 0.022 0.0218
Giardia lamblia Aldose reductase 0.0316 1 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Trypanosoma brucei prostaglandin f synthase 0.0316 1 1
Brugia malayi nuclear receptor NHR-88 0.0016 0.022 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1269 0.1268
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0316 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0092 0.2686 0.2289
Echinococcus granulosus aldehyde reductase 0.0225 0.7018 0.7017
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0798 0.0796
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Brugia malayi nuclear receptor RXR 0.0016 0.022 0.022
Echinococcus multilocularis aldehyde reductase 0.0225 0.7018 0.7017
Mycobacterium leprae Conserved hypothetical protein 0.0225 0.7018 0.5922
Trichomonas vaginalis aldo/keto reductase, putative 0.0316 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0515 0.0514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1269 0.1269
Trichomonas vaginalis aldo/keto reductase, putative 0.0316 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1269 0.1268
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.022 0.0218
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0798 0.0796
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0207 0.6435 0.6435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0798 0.0798
Trypanosoma brucei aldo-keto reductase, putative 0.0316 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.022 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0798 0.0798
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0316 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0798 0.0798
Loa Loa (eye worm) DR-78 0.0016 0.022 0.022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Brugia malayi tailless protein 0.0016 0.022 0.022
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.022 0.022
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.022 0.0218
Brugia malayi Protein kinase domain containing protein 0.0025 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0282
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0282
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0798 0.0796
Loa Loa (eye worm) hypothetical protein 0.0207 0.6435 0.6435
Onchocerca volvulus 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Brugia malayi nuclear hormone receptor 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase 0.0316 1 1
Schistosoma mansoni zinc finger protein 0.0016 0.022 0.0218
Brugia malayi hypothetical protein 0.0018 0.0282 0.0282
Onchocerca volvulus 0.0011 0.0065 0.0065
Trichomonas vaginalis aldo/keto reductase, putative 0.0316 1 1
Onchocerca volvulus 0.0011 0.0065 0.0065
Schistosoma mansoni nuclear hormone receptor 0.0016 0.022 0.0218
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0316 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0798 0.0798
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0798 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0316 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0092 0.2686 0.2289
Onchocerca volvulus 0.0316 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.022 0.022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0798 0.0796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0798 0.0798
Schistosoma mansoni aldo-keto reductase 0.0316 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0282 0.028
Brugia malayi NADH-dependent xylose reductase 0.0092 0.2686 0.2686
Onchocerca volvulus 0.0316 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0092 0.2686 1
Onchocerca volvulus 0.0011 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0282 0.0282
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0316 1 1
Schistosoma mansoni nuclear receptor 0.0016 0.022 0.0218
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0798 0.0796
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0798 0.0796
Echinococcus granulosus aldo keto reductase 0.0316 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.0034 0.0798 0.0798
Loa Loa (eye worm) oxidoreductase 0.0316 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.022 0.022
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.022 0.022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0316 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0316 1 1
Brugia malayi SEA domain containing protein 0.0011 0.0065 0.0065
Brugia malayi nuclear receptor NHR-88 0.0034 0.0798 0.0798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1269 0.1268
Echinococcus multilocularis aldo keto reductase 0.0316 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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