TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 511.535 | Formula: C28H28F3N3O3
H donors: 2 H acceptors: 3 LogP: 3.73 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.CC1OC(C)CN(C1)Cc1cccc(c1)c1ccc(cc1)c1nc2c([nH]1)cccc2
InChi: 1S/C26H27N3O.C2HF3O2/c1-18-15-29(16-19(2)30-18)17-20-6-5-7-23(14-20)21-10-12-22(13-11-21)26-27-24-8-3-4-9-25(24)28-26;3-2(4,5)1(6)7/h3-14,18-19H,15-17H2,1-2H3,(H,27,28);(H,6,7)
InChiKey: AGISROZDMSCXCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0107	0.0424	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Schistosoma mansoni	tyrosine kinase	0.0128	0.0563	0.0825
Echinococcus multilocularis	aldo keto reductase	0.0154	0.074	0.1153
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0058	0.0092	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0421	0.2557	0.884
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Echinococcus granulosus	epidermal growth factor receptor	0.0058	0.0092	0.0143
Schistosoma mansoni	pol-related	0.0154	0.074	0.1084
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0471	0.2892	0.4504
Echinococcus granulosus	conserved hypothetical protein	0.006	0.0103	0.0161
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Brugia malayi	hypothetical protein	0.0107	0.0424	0.1465
Mycobacterium ulcerans	oxidoreductase	0.0154	0.074	0.074
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0311	0.0456
Trypanosoma brucei	aldo-keto reductase, putative	0.0154	0.074	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Loa Loa (eye worm)	oxidoreductase	0.0154	0.074	0.256
Plasmodium vivax	hypothetical protein, conserved	0.006	0.0103	0.2441
Giardia lamblia	Aldose reductase	0.0154	0.074	0.5
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0107	0.0424	0.062
Trichomonas vaginalis	aldo/keto reductase, putative	0.0154	0.074	1
Echinococcus multilocularis		0.0107	0.0424	0.066
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0107	0.0424	0.066
Loa Loa (eye worm)	hypothetical protein	0.0154	0.074	0.256
Plasmodium vivax	hypothetical protein, conserved	0.006	0.0103	0.2441
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0107	0.0424	0.5722
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0128	0.0563	0.0877
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0154	0.074	0.256
Onchocerca volvulus		0.006	0.0103	0.0358
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.0311	0.4207
Echinococcus granulosus	aldo keto reductase	0.0154	0.074	0.1153
Trichomonas vaginalis	aldo/keto reductase, putative	0.0154	0.074	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0128	0.0563	0.0877
Leishmania major	UDP-galactopyranose mutase	0.0107	0.0424	0.5722
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0421	0.2557	0.884
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0058	0.0092	0.0143
Loa Loa (eye worm)	TK/INSR protein kinase	0.0128	0.0563	0.1947
Schistosoma mansoni	tyrosine kinase	0.0057	0.0085	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0177	0.0611
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Schistosoma mansoni	amine oxidase	0.0107	0.0424	0.062
Brugia malayi	RE40412p	0.006	0.0103	0.0358
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Leishmania major	hypothetical protein, unknown function	0.006	0.0103	0.1397
Schistosoma mansoni	tyrosine kinase	0.0058	0.0092	0.0134
Echinococcus multilocularis	aldo keto reductase	0.0154	0.074	0.1153
Echinococcus multilocularis	aldo keto reductase	0.0154	0.074	0.1153
Schistosoma mansoni	aldo-keto reductase	0.0154	0.074	0.1084
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0471	0.2892	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Echinococcus multilocularis	insulin receptor	0.0128	0.0563	0.0877
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Trypanosoma brucei	prostaglandin f synthase	0.0154	0.074	1
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0471	0.2892	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0154	0.074	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0107	0.0424	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0154	0.074	0.256
Loa Loa (eye worm)	oxidoreductase	0.0154	0.074	0.256
Schistosoma mansoni	tyrosine kinase	0.0057	0.0085	0.0124
Echinococcus multilocularis	conserved hypothetical protein	0.006	0.0103	0.0161
Brugia malayi	RE40412p	0.006	0.0103	0.0358
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0107	0.0424	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Echinococcus granulosus	insulin receptor	0.0128	0.0563	0.0877
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0107	0.0424	0.5
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.006	0.0103	0.2441
Toxoplasma gondii	PfMNL-2 CISD1 family iron-sulfur protein, putative	0.006	0.0103	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0107	0.0424	0.5722
Schistosoma mansoni	tyrosine kinase	0.0128	0.0563	0.0825
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0424	1
Entamoeba histolytica	aldose reductase, putative	0.0154	0.074	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0154	0.074	1
Echinococcus multilocularis	aldo keto reductase	0.0154	0.074	0.1153
Loa Loa (eye worm)	oxidoreductase	0.0154	0.074	0.256
Entamoeba histolytica	protein kinase, putative	0.009	0.0311	0.4207
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0107	0.0424	0.062
Echinococcus multilocularis	aldehyde reductase	0.0109	0.0438	0.0683
Onchocerca volvulus		0.006	0.0103	0.0358
Schistosoma mansoni	tyrosine kinase	0.0058	0.0092	0.0134
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0107	0.0424	0.5722
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0471	0.2892	0.4504
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Plasmodium falciparum	protoporphyrinogen oxidase	0.0107	0.0424	1
Toxoplasma gondii	zinc finger CDGSH-type domain-containing protein	0.006	0.0103	0.1397
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0107	0.0424	0.0424
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0471	0.2892	1
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.006	0.0103	0.2441
Echinococcus multilocularis	dual specificity	0.009	0.0311	0.0485
Entamoeba histolytica	aldose reductase, putative	0.0154	0.074	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0154	0.074	1
Brugia malayi	Protein kinase domain containing protein	0.0128	0.0563	0.1947
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0154	0.074	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0058	0.0092	0.0143
Mycobacterium ulcerans	monoamine oxidase	0.0107	0.0424	0.0424
Loa Loa (eye worm)	hypothetical protein	0.007	0.017	0.0587
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0107	0.0424	1
Plasmodium vivax	hypothetical protein, conserved	0.006	0.0103	0.2441
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.009	0.0311	0.4207
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0311	0.4207
Loa Loa (eye worm)	hypothetical protein	0.006	0.0103	0.0358
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0154	0.074	1
Trypanosoma cruzi	aldo-keto reductase	0.0154	0.074	1
Echinococcus granulosus	epidermal growth factor receptor	0.0058	0.0092	0.0143
Brugia malayi	Furin-like cysteine rich region family protein	0.0058	0.0092	0.0317
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0107	0.0424	0.0457
Schistosoma mansoni	tyrosine kinase	0.0057	0.0085	0.0124
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0471	0.2892	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Entamoeba histolytica	protein kinase, putative	0.009	0.0311	0.4207
Brugia malayi	GH02984p	0.034	0.2002	0.692
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0154	0.074	1
Entamoeba histolytica	hypothetical protein	0.009	0.0311	0.4207
Loa Loa (eye worm)	hypothetical protein	0.034	0.2002	0.692
Onchocerca volvulus		0.0154	0.074	0.256
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0107	0.0424	0.5722
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Echinococcus granulosus	dual specificity	0.009	0.0311	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0286	0.0991
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Leishmania major	aldo-keto reductase-like protein	0.0154	0.074	1
Schistosoma mansoni	hypothetical protein	0.1051	0.6827	1
Leishmania major	prostaglandin f synthase, putative	0.0154	0.074	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Echinococcus granulosus	aldo keto reductase	0.0154	0.074	0.1153
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.0991	0.6422	1
Giardia lamblia	Aldose reductase	0.0154	0.074	0.5
Entamoeba histolytica	aldose reductase, putative	0.0154	0.074	1
Schistosoma mansoni	aldo-keto reductase	0.0154	0.074	0.1084
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.006	0.0103	0.2441
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0154	0.074	0.256
Onchocerca volvulus		0.0154	0.074	0.256
Onchocerca volvulus		0.0107	0.0424	0.1465
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0107	0.0424	0.066
Echinococcus granulosus	hypothetical protein	0.0154	0.074	0.1153
Brugia malayi	Protein kinase domain containing protein	0.0471	0.2892	1
Onchocerca volvulus		0.0421	0.2557	0.884
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.009	0.0311	0.1077
Schistosoma mansoni	serine/threonine protein kinase	0.0471	0.2892	0.4237
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1412	0.9275	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.009	0.0311	0.4207
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.1051	0.6827	1
Onchocerca volvulus		0.0154	0.074	0.256
Mycobacterium ulcerans	dehydrogenase	0.0107	0.0424	0.0424
Toxoplasma gondii	histone lysine-specific demethylase	0.0107	0.0424	0.5722
Toxoplasma gondii	aldose reductase, putative	0.0154	0.074	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0107	0.0424	0.1465
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Loa Loa (eye worm)	oxidoreductase	0.0154	0.074	0.256
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Brugia malayi	Protein kinase domain containing protein	0.009	0.0311	0.1077
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0058	0.0092	0.0317
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0424	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0154	0.074	0.256
Loa Loa (eye worm)	oxidoreductase	0.0154	0.074	0.256
Schistosoma mansoni	tyrosine kinase	0.0058	0.0092	0.0134
Toxoplasma gondii	zinc finger cdgsh type protein	0.006	0.0103	0.1397
Mycobacterium leprae	Conserved hypothetical protein	0.0109	0.0438	0.5922
Loa Loa (eye worm)	hypothetical protein	0.006	0.0103	0.0358
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0154	0.074	0.1153
Echinococcus granulosus	aldehyde reductase	0.0109	0.0438	0.0683
Onchocerca volvulus		0.0154	0.074	0.256
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.0311	0.4207
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1519	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0154	0.074	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Echinococcus multilocularis	high affinity choline transporter 1	0.034	0.2002	0.3117
Trichomonas vaginalis	aldo-keto reductase, putative	0.0154	0.074	1
Echinococcus granulosus	high affinity choline transporter 1	0.034	0.2002	0.3117
Schistosoma mansoni	amine oxidase	0.0107	0.0424	0.062
Onchocerca volvulus		0.0154	0.074	0.256
Trichomonas vaginalis	aldo/keto reductase, putative	0.0154	0.074	1
Mycobacterium ulcerans	hypothetical protein	0.0212	0.1135	0.1135
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0286	0.0991
Echinococcus granulosus	aldo keto reductase	0.0154	0.074	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0424	0.1465
Schistosoma mansoni	high-affinity choline transporter	0.034	0.2002	0.2932
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0107	0.0424	0.066
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Onchocerca volvulus		0.0154	0.074	0.256
Mycobacterium tuberculosis	Probable oxidoreductase	0.0154	0.074	0.0798
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0154	0.074	0.1153
Brugia malayi	SWIRM domain containing protein	0.0107	0.0424	0.1465
Mycobacterium tuberculosis	Possible oxidoreductase	0.0107	0.0424	0.0457
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.0991	0.6422	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0107	0.0424	0.066
Mycobacterium ulcerans	oxidoreductase	0.0107	0.0424	0.0424
Schistosoma mansoni	hypothetical protein	0.006	0.0103	0.0151

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 2.3 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 3.06 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 4.42 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 37 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 88 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 90 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 1.41	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -6 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 37 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 88 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 90 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.07	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.85664 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL534326
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 591777