Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0679 | 0.0384 | 0.0872 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2036 | 0.4411 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1396 | 0.2513 | 0.3095 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2532 | 0.5882 | 0.5769 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Plasmodium vivax | vivapain-2 | 0.2036 | 0.4411 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.1537 | 0.293 | 0.2737 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.111 | 0.1663 | 0.1434 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1537 | 0.293 | 0.2737 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2532 | 0.5882 | 0.5769 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.111 | 0.1663 | 0.1434 |
Loa Loa (eye worm) | cysteine protease | 0.2036 | 0.4411 | 0.4257 |
Brugia malayi | cathepsin L-like precursor | 0.1396 | 0.2513 | 0.2308 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.111 | 0.1663 | 0.1434 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Leishmania major | cathepsin L-like protease | 0.2532 | 0.5882 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.111 | 0.1663 | 0.1434 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1396 | 0.2513 | 0.5547 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.2036 | 0.4411 | 0.3296 |
Toxoplasma gondii | cathepsin CPC1 | 0.0679 | 0.0384 | 0.0872 |
Toxoplasma gondii | cathepsin B | 0.1537 | 0.293 | 0.6644 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0679 | 0.0384 | 0.0872 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.111 | 0.1663 | 0.1434 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2036 | 0.4411 | 0.3296 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0679 | 0.0384 | 0.0872 |
Onchocerca volvulus | Cathepsin L homolog | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.111 | 0.1663 | 0.3551 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3919 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0696 | 0.0435 | 0.1483 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Toxoplasma gondii | cathepsin CPL | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2036 | 0.4411 | 0.4257 |
Echinococcus multilocularis | cysteine protease | 0.2036 | 0.4411 | 0.3296 |
Leishmania major | cathepsin L-like protease | 0.2036 | 0.4411 | 0.5016 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2036 | 0.4411 | 0.4257 |
Brugia malayi | Cathepsin L-like precursor | 0.1396 | 0.2513 | 0.2308 |
Onchocerca volvulus | Cathepsin L homolog | 0.2036 | 0.4411 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0966 | 0.1236 | 0.0996 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Plasmodium vivax | unspecified product | 0.111 | 0.1663 | 0.377 |
Echinococcus multilocularis | cysteine protease | 0.2036 | 0.4411 | 0.3296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0696 | 0.0435 | 0.067 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3919 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3919 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.2036 | 0.4411 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3919 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.111 | 0.1663 | 0.1434 |
Plasmodium vivax | unspecified product | 0.0639 | 0.0267 | 0.0605 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0679 | 0.0384 | 0.0121 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2036 | 0.4411 | 0.3296 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3919 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1537 | 0.293 | 0.3005 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.111 | 0.1663 | 0.1434 |
Giardia lamblia | Cathepsin B precursor | 0.1537 | 0.293 | 1 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Leishmania major | cathepsin L-like protease | 0.2532 | 0.5882 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2036 | 0.4411 | 1 |
Plasmodium vivax | vivapain-3 | 0.111 | 0.1663 | 0.377 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0696 | 0.0435 | 0.0173 |
Leishmania major | cathepsin L-like protease | 0.2036 | 0.4411 | 0.5016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Echinococcus granulosus | cathepsin b | 0.3919 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1892 | 0.3984 | 0.3819 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2036 | 0.4411 | 0.4257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1396 | 0.2513 | 0.5547 |
Leishmania major | cathepsin L-like protease | 0.2532 | 0.5882 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.2036 | 0.4411 | 0.5016 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2036 | 0.4411 | 0.4257 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1396 | 0.2513 | 0.2308 |
Echinococcus granulosus | cathepsin l1 | 0.1396 | 0.2513 | 0.102 |
Onchocerca volvulus | 0.2036 | 0.4411 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.111 | 0.1663 | 0.1434 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2036 | 0.4411 | 0.4257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0679 | 0.0384 | 0.1312 |
Leishmania major | cathepsin L-like protease | 0.2036 | 0.4411 | 0.5016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2036 | 0.4411 | 0.3296 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2036 | 0.4411 | 0.4257 |
Loa Loa (eye worm) | hypothetical protein | 0.1396 | 0.2513 | 0.2308 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Leishmania major | cathepsin L-like protease | 0.2036 | 0.4411 | 0.5016 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2036 | 0.4411 | 0.3296 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.2532 | 0.5882 | 0.5769 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | fibroinase | 0.2036 | 0.4411 | 0.4257 |
Giardia lamblia | Cathepsin B precursor | 0.1537 | 0.293 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2036 | 0.4411 | 0.3296 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1537 | 0.293 | 0.2737 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.111 | 0.1663 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.1396 | 0.2513 | 0.2308 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2532 | 0.5882 | 0.5769 |
Loa Loa (eye worm) | hypothetical protein | 0.1396 | 0.2513 | 0.2308 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0696 | 0.0435 | 0.0173 |
Echinococcus granulosus | cathepsin b | 0.3919 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3919 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.111 | 0.1663 | 0.377 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3919 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.111 | 0.1663 | 0.3551 |
Loa Loa (eye worm) | hypothetical protein | 0.3919 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.2036 | 0.4411 | 0.5016 |
Entamoeba histolytica | cysteine protease, putative | 0.2036 | 0.4411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0696 | 0.0435 | 0.067 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.111 | 0.1663 | 0.1434 |
Brugia malayi | Cathepsin L-like precursor | 0.1396 | 0.2513 | 0.2308 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1537 | 0.293 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0696 | 0.0435 | 0.067 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2036 | 0.4411 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.2036 | 0.4411 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2036 | 0.4411 | 0.3296 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.111 | 0.1663 | 0.377 |
Brugia malayi | Cathepsin L-like precursor | 0.2036 | 0.4411 | 0.4257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0696 | 0.0435 | 0.067 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0696 | 0.0435 | 0.0173 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0679 | 0.0384 | 0.0872 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1396 | 0.2513 | 0.2308 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2036 | 0.4411 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.2036 | 0.4411 | 0.4257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1537 | 0.293 | 0.6526 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2036 | 0.4411 | 0.4257 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0679 | 0.0384 | 0.0872 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2532 | 0.5882 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2036 | 0.4411 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration against Escherichia coli | ChEMBL. | 12699374 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus | ChEMBL. | 12699374 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration against methicillin-resistant S. aureus (ATCC 33591) | ChEMBL. | 12699374 |
MIC (functional) | = 200 ug ml-1 | Minimum inhibitory concentration against methicillin-resistant S. epidermidis (ATCC 27626) | ChEMBL. | 12699374 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration against Escherichia coli | ChEMBL. | 12699374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.