Detailed information for compound 60774

Basic information

Technical information
  • TDR Targets ID: 60774
  • Name: 4-(2,2-dimethyl-1-prop-2-enoxypropyl)benzoic acid
  • MW: 248.317 | Formula: C15H20O3
  • H donors: 1 H acceptors: 2 LogP: 3.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOC(C(C)(C)C)c1ccc(cc1)C(=O)O
  • InChi: 1S/C15H20O3/c1-5-10-18-13(15(2,3)4)11-6-8-12(9-7-11)14(16)17/h5-9,13H,1,10H2,2-4H3,(H,16,17)
  • InChiKey: NIFLIMZCOWAOGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-allyloxy-2,2-dimethyl-propyl)benzoic acid
  • 4-(1-allyloxy-2,2-dimethylpropyl)benzoic acid
  • 4-(2,2-dimethyl-1-prop-2-enoxy-propyl)benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin b 0.364 1 1
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Echinococcus multilocularis cathepsin b 0.364 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0411 0.0978 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Loa Loa (eye worm) cathepsin B 0.1274 0.339 0.339
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.008 0.008
Toxoplasma gondii cathepsin CPL 0.0699 0.1781 0.4564
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Entamoeba histolytica cysteine proteinase, putative 0.0503 0.1234 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Onchocerca volvulus 0.0699 0.1781 1
Brugia malayi Papain family cysteine protease containing protein 0.0411 0.0978 0.0978
Leishmania major cathepsin L-like protease 0.0752 0.193 0.0921
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0215 0.0431 0.0385
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.0618 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.0503 0.1234 0.1234
Trypanosoma brucei cysteine peptidase C (CPC) 0.1274 0.339 1
Schistosoma mansoni tyrosinase precursor 0.009 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.364 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0752 0.193 0.1614
Onchocerca volvulus 0.0699 0.1781 1
Trypanosoma cruzi cysteine protease, putative 0.0411 0.0978 0.0625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.364 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0215 0.0431 0.0431
Brugia malayi Cathepsin L-like precursor 0.0196 0.0377 0.0377
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0215 0.0431 0.0431
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0215 0.0431 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0556 0.1382 0.1045
Entamoeba histolytica cysteine proteinase, putative 0.0699 0.1781 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Leishmania major cathepsin L-like protease 0.0752 0.193 0.0921
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0215 0.0431 0.0385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Entamoeba histolytica cysteine proteinase 2 0.0411 0.0978 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0215 0.0431 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0699 0.1781 0.1781
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1274 0.339 0.3132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0503 0.1234 0.2714
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0215 0.0431 0.0431
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.0978 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0411 0.0978 0.0978
Echinococcus multilocularis cathepsin L 0.0411 0.0978 0.0978
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Onchocerca volvulus 0.0699 0.1781 1
Plasmodium vivax vivapain-2 0.0699 0.1781 1
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.0978 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0699 0.1781 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0699 0.1781 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0699 0.1781 0.1781
Schistosoma mansoni cathepsin B (C01 family) 0.0215 0.0431 0.0431
Brugia malayi cathepsin F-like cysteine proteinase 0.0215 0.0431 0.0431
Echinococcus multilocularis cysteine protease 0.0699 0.1781 0.1781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0215 0.0431 0.0431
Echinococcus granulosus cathepsin l1 0.0699 0.1781 0.1781
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0215 0.0431 0.0431
Trypanosoma cruzi cysteine peptidase, putative 0.0752 0.193 0.1614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0699 0.1781 0.1781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0215 0.0431 0.0385
Plasmodium vivax serine-repeat antigen (SERA) 0.0215 0.0431 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Brugia malayi cathepsin Z-like cysteine proteinase 0.0215 0.0431 0.0431
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.008 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0215 0.0431 0.0431
Brugia malayi Cathepsin L-like precursor 0.0503 0.1234 0.1234
Onchocerca volvulus 0.0503 0.1234 0.6781
Loa Loa (eye worm) hypothetical protein 0.0196 0.0377 0.0377
Loa Loa (eye worm) fibroinase 0.0699 0.1781 0.1781
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Plasmodium vivax vivapain-2 0.0699 0.1781 1
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.008
Onchocerca volvulus 0.0699 0.1781 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0699 0.1781 0.1781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0699 0.1781 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Toxoplasma gondii cathepsin B 0.1274 0.339 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Echinococcus granulosus cathepsin l cysteine peptidase 0.0699 0.1781 0.1781
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.0978 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0215 0.0431 0.0431
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0215 0.0431 0.0385
Entamoeba histolytica cysteine protease, putative 0.0699 0.1781 1
Echinococcus granulosus cathepsin l1 0.0503 0.1234 0.1234
Schistosoma mansoni cathepsin F (C01 family) 0.0699 0.1781 0.1781
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0196 0.0377 0.0377
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0215 0.0431 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Schistosoma mansoni cathepsin F (C01 family) 0.0699 0.1781 0.1781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1274 0.339 0.339
Schistosoma mansoni cathepsin C 0.0215 0.0431 0.0431
Brugia malayi Cathepsin L-like precursor 0.0503 0.1234 0.1234
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0215 0.0431 0.0385
Brugia malayi cathepsin Z-like cysteine proteinase 0.0215 0.0431 0.0431
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0215 0.0431 0.0431
Trypanosoma cruzi major cysteine proteinase, putative 0.0215 0.0431 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0215 0.0431 0.0431
Echinococcus granulosus cathepsin L cysteine protease 0.0411 0.0978 0.0978
Loa Loa (eye worm) cysteine protease 0.0699 0.1781 0.1781
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.0978 0.185
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.364 1 1
Echinococcus granulosus cathepsin b 0.364 1 1
Loa Loa (eye worm) tyrosinase 1 0.009 0.008 0.008
Onchocerca volvulus Cathepsin L homolog 0.0215 0.0431 0.2059
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0618 0.1387
Trypanosoma cruzi cysteine peptidase, putative 0.0699 0.1781 0.146
Loa Loa (eye worm) hypothetical protein 0.0196 0.0377 0.0377
Plasmodium vivax unspecified product 0.0215 0.0431 0.0385
Echinococcus multilocularis cathepsin b 0.364 1 1
Schistosoma mansoni tyrosinase precursor 0.009 0.008 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0699 0.1781 1
Trypanosoma cruzi cysteine proteinase, putative 0.0411 0.0978 0.0625
Giardia lamblia Cathepsin B precursor 0.1274 0.339 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Loa Loa (eye worm) ctsf protein 0.0699 0.1781 0.1781
Trypanosoma cruzi cysteine proteinase, putative 0.0411 0.0978 0.0625
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.008 0.008
Schistosoma mansoni cathepsin F (C01 family) 0.0503 0.1234 0.1234
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0196 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.364 1 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.0377 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.0978 0.0625
Entamoeba histolytica cysteine proteinase 1, putative 0.0411 0.0978 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Plasmodium falciparum cysteine proteinase falcipain 3 0.0699 0.1781 1
Brugia malayi Papain family cysteine protease containing protein 0.0215 0.0431 0.0431
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0215 0.0431 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0411 0.0978 0.0978
Onchocerca volvulus Cathepsin F homolog 0.0699 0.1781 1
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.364 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0215 0.0431 0.0431
Echinococcus granulosus cathepsin L cysteine proteinase 0.0699 0.1781 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Brugia malayi fibroinase precursor 0.0215 0.0431 0.0431
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0196 0.0377 0.0377
Plasmodium vivax serine-repeat antigen (SERA) 0.0215 0.0431 0.0385
Giardia lamblia Cathepsin B precursor 0.1274 0.339 1
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0699 0.1781 0.1781
Onchocerca volvulus 0.0215 0.0431 0.2059
Plasmodium vivax vivapain-3 0.0411 0.0978 0.4283
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0214 0.5
Onchocerca volvulus 0.0699 0.1781 1
Brugia malayi cathepsin L-like precursor 0.0503 0.1234 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0215 0.0431 0.0431
Onchocerca volvulus Cathepsin L homolog 0.0699 0.1781 1
Brugia malayi ShTK domain containing protein 0.009 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.008 0.008
Echinococcus multilocularis cathepsin L 0.0215 0.0431 0.0431
Brugia malayi Papain family cysteine protease containing protein 0.0699 0.1781 0.1781
Trypanosoma cruzi major cysteine proteinase, putative 0.0268 0.0579 0.021
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0215 0.0431 0.0385
Onchocerca volvulus 0.0699 0.1781 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0214 0.5
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0215 0.0431 0.0385
Onchocerca volvulus 0.0699 0.1781 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.0978 0.185
Schistosoma mansoni cathepsin s 0.0196 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0503 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.0699 0.1781 0.1781
Brugia malayi Papain family cysteine protease containing protein 0.0411 0.0978 0.0978
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1274 0.339 1
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.0978 0.4054
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0503 0.1234 0.2714
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0411 0.0978 0.0625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Echinococcus granulosus cathepsin L 0.0411 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.0618 0.0633
Echinococcus granulosus cathepsin L 0.0215 0.0431 0.0431
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0215 0.0431 0.0431
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0215 0.0431 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1274 0.339 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0215 0.0431 0.0431
Schistosoma mansoni serine-type protease inhibitor 0.1879 0.5079 0.5079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0618 0.0633
Echinococcus granulosus cysteine protease 0.0411 0.0978 0.0978
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.364 1 1
Plasmodium vivax unspecified product 0.0411 0.0978 0.4283
Leishmania major cathepsin L-like protease 0.0752 0.193 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0752 0.193 0.3944
Loa Loa (eye worm) hypothetical protein 0.0215 0.0431 0.0431
Echinococcus multilocularis cysteine protease 0.0699 0.1781 0.1781
Brugia malayi Cathepsin L-like precursor 0.0699 0.1781 0.1781
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0215 0.0431 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0699 0.1781 0.4564
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0214 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0618 0.1387
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0699 0.1781 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0699 0.1781 0.4564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Loa Loa (eye worm) hypothetical protein 0.0503 0.1234 0.1234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.1781 0.4564
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0752 0.193 0.1614
Loa Loa (eye worm) hypothetical protein 0.0503 0.1234 0.1234
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Schistosoma mansoni serine-type protease inhibitor 0.1879 0.5079 0.5079
Brugia malayi cathepsin L precursor 0.0215 0.0431 0.0431
Brugia malayi cathepsin L-like cysteine proteinase 0.0215 0.0431 0.0431
Plasmodium vivax vivapain-1 0.0411 0.0978 0.4283
Entamoeba histolytica cysteine protease, putative 0.0411 0.0978 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.1781 0.4564
Plasmodium falciparum cysteine proteinase falcipain 1 0.0411 0.0978 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0752 0.193 0.1614
Giardia lamblia Cathepsin B precursor 0.1274 0.339 1

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 941 ug hr ml-1 AUC was measured from the graph plotted against blood plasma concentration and time at the dose of 300 uMol/kg ChEMBL. 9888840
Control (functional) < 29 % Ketone levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840
Control (functional) = 107 % Glucose levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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