Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5742 | 0.9152 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0399 | 0.7717 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.6274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5742 | 0.9152 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0122 | 0.1685 | 0.2686 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0122 | 0.1685 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0122 | 0.1685 | 0.2686 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0122 | 0.1685 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1321 | 0.2105 |
Echinococcus multilocularis | fk506 binding protein | 0.0122 | 0.1685 | 1 |
Onchocerca volvulus | 0.0328 | 0.6172 | 0.5 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0122 | 0.1685 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0105 | 0.1321 | 0.7838 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0352 | 0.6704 | 1 |
Schistosoma mansoni | immunophilin | 0.0122 | 0.1685 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0122 | 0.1685 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0122 | 0.1685 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0122 | 0.1685 | 1 |
Schistosoma mansoni | immunophilin | 0.0105 | 0.1321 | 0.7838 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0399 | 0.7717 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0122 | 0.1685 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0105 | 0.1321 | 0.7838 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0122 | 0.1685 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0122 | 0.1685 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0122 | 0.1685 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0122 | 0.1685 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0122 | 0.1685 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5742 | 0.9152 |
Schistosoma mansoni | immunophilin | 0.0122 | 0.1685 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0122 | 0.1685 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0122 | 0.1685 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of human recombinant interstitial collagenase MMP-1 at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 0 % | Inhibition of human recombinant interstitial collagenase MMP-1 at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 22 % | Inhibition of human recombinant 92 kDa gelatinase MMP-9 at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 22 % | Inhibition of human recombinant 92 kDa gelatinase MMP-9 at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 38 % | Inhibition of human recombinant matrix metalloproteinase-3 (Stromelysin) at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 38 % | Inhibition of human recombinant matrix metalloproteinase-3 (Stromelysin) at 10 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.