TDR Targets

Basic information

Technical information

TDR Targets ID: 615867
Name: 2-[(2,4-dimethylbenzoyl)amino]-6-propyl-5,7-d ihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
MW: 371.496 | Formula: C20H25N3O2S
H donors: 2 H acceptors: 2 LogP: 3.73 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCN1CCc2c(C1)sc(c2C(=O)N)NC(=O)c1ccc(cc1C)C
InChi: 1S/C20H25N3O2S/c1-4-8-23-9-7-15-16(11-23)26-20(17(15)18(21)24)22-19(25)14-6-5-12(2)10-13(14)3/h5-6,10H,4,7-9,11H2,1-3H3,(H2,21,24)(H,22,25)
InChiKey: RPEQHPIJUHTAQK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[(2,4-dimethylphenyl)-oxomethyl]amino]-6-propyl-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
2-[(2,4-dimethylphenyl)carbonylamino]-6-propyl-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0161	0.0353	0.1159
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0367	0.1138	0.3732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0367	0.1138	0.3732
Brugia malayi	hypothetical protein	0.0161	0.0353	0.1159
Schistosoma mansoni	RAR-like nuclear receptor	0.0367	0.1138	0.1138
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0187	0.0613
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0367	0.1138	0.1138
Brugia malayi	ecdysteroid receptor	0.087	0.3049	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Schistosoma mansoni	nuclear hormone receptor	0.0367	0.1138	0.1138
Schistosoma mansoni	hypothetical protein	0.0164	0.0365	0.0365
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0092	0.0093	0.0093
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0161	0.0353	0.0353
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0367	0.1138	0.3732
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0367	0.1138	0.1138
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0206	0.0527	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0367	0.1138	0.3732
Brugia malayi	Steroid receptor seven-up type 2	0.0367	0.1138	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0206	0.0527	0.1727
Brugia malayi	conserved hypotetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0527	0.1727
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0367	0.1138	0.1138
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0367	0.1138	0.1138
Brugia malayi	hypothetical protein	0.0206	0.0527	0.1727
Brugia malayi	orphan nuclear receptor NR2E1	0.0161	0.0353	0.1159
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0187	0.0613
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0367	0.1138	0.1138
Onchocerca volvulus		0.0146	0.0298	0.0642
Brugia malayi	Nuclear hormone receptor-like 1	0.0367	0.1138	0.3732
Echinococcus granulosus	tumor protein p63	0.066	0.2251	0.2251
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0161	0.0353	0.0353
Onchocerca volvulus	Protein ultraspiracle homolog	0.0367	0.1138	0.3498
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0367	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Brugia malayi	nuclear receptor RXR	0.0161	0.0353	0.1159
Echinococcus multilocularis	ecdysone induced protein 78C	0.0367	0.1138	0.1138
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0092	0.0093	0.0093
Schistosoma mansoni	microtubule-associated protein tau	0.2698	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0161	0.0353	0.0353
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0161	0.0353	0.083
Echinococcus multilocularis	geminin	0.0164	0.0365	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0367	0.1138	0.3732
Brugia malayi	steroid hormone receptor	0.0837	0.2923	0.9586
Brugia malayi	Nuclear hormone receptor-like 1	0.0206	0.0527	0.1727
Brugia malayi	nuclear hormone receptor	0.0367	0.1138	0.3732
Echinococcus multilocularis	GPCR, family 2	0.0092	0.0093	0.0093
Echinococcus granulosus	GPCR family 2	0.0092	0.0093	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0367	0.1138	0.3732
Schistosoma mansoni	nuclear hormone receptor	0.0161	0.0353	0.0353
Schistosoma mansoni	zinc finger protein	0.0161	0.0353	0.0353
Schistosoma mansoni	retinoic acid receptor RXR	0.0367	0.1138	0.1138
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0092	0.0093	0.0305
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0093	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0367	0.1138	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0199	0.05	0.1641
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0161	0.0353	0.1159
Brugia malayi	nuclear receptor NHR-88	0.0367	0.1138	0.3732
Onchocerca volvulus		0.0367	0.1138	0.3498
Loa Loa (eye worm)	hypothetical protein	0.087	0.3049	1
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0161	0.0353	0.0353
Brugia malayi	MH2 domain containing protein	0.0117	0.0187	0.0613
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0367	0.1138	0.1138
Schistosoma mansoni	nuclear receptor	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0527	0.1727
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0161	0.0353	0.0353
Echinococcus multilocularis	FTZ F1 alpha	0.0367	0.1138	0.1138
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0092	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0164	0.0365	0.0365
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0367	0.1138	0.1138
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0367	0.1138	0.1138
Onchocerca volvulus	Bile acid receptor homolog	0.087	0.3049	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0367	0.1138	0.3732
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0367	0.1138	0.1138
Brugia malayi	photoreceptor-specific nuclear receptor	0.0367	0.1138	0.3732
Schistosoma mansoni	hypothetical protein	0.0092	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0367	0.1138	0.3732
Schistosoma mansoni	hypothetical protein	0.0092	0.0093	0.0093
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0527	0.1727
Onchocerca volvulus		0.0161	0.0353	0.083
Loa Loa (eye worm)	nuclear hormone receptor	0.0161	0.0353	0.1159
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0367	0.1138	0.3732
Echinococcus granulosus	thyroid hormone receptor alpha	0.063	0.2138	0.2138
Schistosoma mansoni	cellular tumor antigen P53	0.0097	0.0109	0.0109
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0092	0.0093	0.0093
Schistosoma mansoni	thyroid hormone receptor	0.0367	0.1138	0.1138
Trichomonas vaginalis	chromobox protein, putative	0.0068	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0367	0.1138	0.1138
Echinococcus granulosus	FTZ F1 alpha	0.0367	0.1138	0.1138
Brugia malayi	latrophilin 2 splice variant baaae	0.0199	0.05	0.1641
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0367	0.1138	0.1138
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0367	0.1138	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0298	0.0977
Brugia malayi	nuclear receptor NHR-88	0.0161	0.0353	0.1159
Echinococcus granulosus	ecdysone induced protein 78C	0.0367	0.1138	0.1138
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0367	0.1138	0.1138
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0161	0.0353	0.0353
Schistosoma mansoni	nuclear hormone receptor	0.0161	0.0353	0.0353
Echinococcus granulosus	nuclear receptor nhr 48	0.0161	0.0353	0.0353
Echinococcus multilocularis	tumor protein p63	0.066	0.2251	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0367	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Brugia malayi	nuclear receptor NHR-67	0.0161	0.0353	0.1159
Brugia malayi	nuclear hormone receptor	0.0161	0.0353	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0367	0.1138	0.1138
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0161	0.0353	0.1159
Schistosoma mansoni	hypothetical protein	0.0092	0.0093	0.0093
Brugia malayi	nuclear receptor RXR	0.0206	0.0527	0.1727
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0367	0.1138	0.3732
Onchocerca volvulus		0.0161	0.0353	0.083
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0367	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0527	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0206	0.0527	0.1727
Schistosoma mansoni	hypothetical protein	0.0199	0.05	0.05
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0367	0.1138	0.3498
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0367	0.1138	0.1138
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0367	0.1138	0.3732
Schistosoma mansoni	nuclear receptor	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0292	0.0851	0.2791
Echinococcus granulosus	geminin	0.0164	0.0365	0.0365
Loa Loa (eye worm)	DR-78	0.0161	0.0353	0.1159
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0367	0.1138	0.3732
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0292	0.0851	0.2791
Schistosoma mansoni	thyroid hormone receptor	0.0367	0.1138	0.1138
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0367	0.1138	0.3732
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0367	0.1138	0.3732
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0161	0.0353	0.0353
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0367	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0109	0.0359
Schistosoma mansoni	hypothetical protein	0.0092	0.0093	0.0093
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0367	0.1138	0.1138
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0367	0.1138	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Schistosoma mansoni	nuclear receptor nhr-48	0.0161	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Schistosoma mansoni	coup transcription factor	0.0367	0.1138	0.1138
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0367	0.1138	0.3732
Echinococcus multilocularis	microtubule associated protein 2	0.2698	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0367	0.1138	0.1138
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0206	0.0527	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0161	0.0353	0.1159
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0161	0.0353	0.0353
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0206	0.0527	0.0527
Echinococcus multilocularis	nuclear receptor nhr 48	0.0161	0.0353	0.0353
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0367	0.1138	0.3732
Brugia malayi	nuclear hormone receptor family member odr-7	0.0161	0.0353	0.1159
Brugia malayi	Nuclear hormone receptor-like 1	0.0206	0.0527	0.1727
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0367	0.1138	0.3732
Brugia malayi	tailless protein	0.0161	0.0353	0.1159
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0161	0.0353	0.083
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0353	0.1159
Brugia malayi	Latrophilin receptor protein 2	0.0092	0.0093	0.0305
Brugia malayi	hypothetical protein	0.0146	0.0298	0.0977
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0092	0.0093	0.0305
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0161	0.0353	0.1159
Trichomonas vaginalis	chromobox protein, putative	0.0068	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1138	0.3732
Brugia malayi	hypothetical protein	0.0206	0.0527	0.1727
Brugia malayi	Nuclear hormone receptor E75	0.0161	0.0353	0.1159
Brugia malayi	Nuclear hormone receptor E75	0.0161	0.0353	0.1159
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0292	0.0851	0.2791
Brugia malayi	ecdysone receptor	0.0161	0.0353	0.1159
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0206	0.0527	0.0527
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0367	0.1138	0.1138
Loa Loa (eye worm)	steroid hormone receptor	0.0837	0.2923	0.9586
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0851	0.2791

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 615867