Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.2832 | 0.3487 |
Mycobacterium ulcerans | glutaminase | 0.0283 | 0.7883 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0498 | 0.0478 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0907 | 1 |
Brugia malayi | hypothetical protein | 0.0245 | 0.6673 | 0.844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2942 | 0.3629 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4127 | 0.5157 |
Loa Loa (eye worm) | glutaminase 2 | 0.0283 | 0.7883 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0283 | 0.7883 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2942 | 0.3629 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.2942 | 0.2851 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.2942 | 0.3629 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0538 | 0.053 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0907 | 0.1006 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0538 | 0.053 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0498 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.6673 | 0.844 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0907 | 0.1006 |
Onchocerca volvulus | 0.0051 | 0.0538 | 0.0119 | |
Onchocerca volvulus | 0.0156 | 0.3872 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.2832 | 0.3487 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0498 | 0.0478 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0127 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.2942 | 0.3629 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2942 | 0.3629 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0907 | 0.079 |
Brugia malayi | hypothetical protein | 0.0156 | 0.3872 | 0.4829 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.2942 | 0.2851 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0907 | 0.1006 |
Schistosoma mansoni | glutaminase | 0.0283 | 0.7883 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.4127 | 0.4051 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.6673 | 0.663 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.0907 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.2942 | 0.3629 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.2942 | 0.3629 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0127 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2942 | 0.3629 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0907 | 0.079 |
Trichomonas vaginalis | glutaminase, putative | 0.0283 | 0.7883 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0127 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.035 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.6673 | 0.663 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2942 | 0.3629 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4127 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.3872 | 0.4829 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0127 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.2942 | 0.3629 |
Brugia malayi | glutaminase DH11.1 | 0.0283 | 0.7883 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0907 | 0.1006 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0907 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.2942 | 0.3629 |
Echinococcus granulosus | geminin | 0.0164 | 0.4127 | 0.4051 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.0907 | 0.1006 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.2832 | 0.3487 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0127 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.