Detailed information for compound 625018

Basic information

Technical information
  • TDR Targets ID: 625018
  • Name: 4-(dimethylsulfamoyl)-N-[[4-(phenylmethyl)-5- sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]be nzamide
  • MW: 431.532 | Formula: C19H21N5O3S2
  • H donors: 1 H acceptors: 5 LogP: 1.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N(C)C)NCc1nnc(n1Cc1ccccc1)S
  • InChi: 1S/C19H21N5O3S2/c1-23(2)29(26,27)16-10-8-15(9-11-16)18(25)20-12-17-21-22-19(28)24(17)13-14-6-4-3-5-7-14/h3-11H,12-13H2,1-2H3,(H,20,25)(H,22,28)
  • InChiKey: YRBQPXCDUFUKDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(dimethylsulfamoyl)-N-[[4-(phenylmethyl)-5-thioxo-1H-1,2,4-triazol-3-yl]methyl]benzamide
  • N-[[4-(benzyl)-5-thioxo-1H-1,2,4-triazol-3-yl]methyl]-4-(dimethylsulfamoyl)benzamide
  • EU-0037328
  • Oprea1_038688

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0017 0.0125 0.0225
Schistosoma mansoni P2X receptor subunit 0.0134 0.3561 0.3626
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.1027 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.014 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.1009 0.0926
Loa Loa (eye worm) hypothetical protein 0.0149 0.4032 0.9554
Echinococcus multilocularis dna polymerase eta 0.0019 0.0176 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.2611 0.2543
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1131 0.1086
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0125 0.0034
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0338 0.0258
Leishmania major cathepsin L-like protease 0.0017 0.0125 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0898 0.2797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0898 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.014 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0707 0.0621
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.3561 0.3502
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0176 0.0898
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.014 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0125 0.0225
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0898 0.0814
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0951 0.2083
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.014 0.0891
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0176 0.0166
Loa Loa (eye worm) hypothetical protein 0.0047 0.1009 0.2225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.2611 0.6109
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.1027 0.3266
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0125 0.4774
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.4032 0.9554
Echinococcus granulosus cathepsin l1 0.0017 0.0125 0.0034
Schistosoma mansoni glycogen phosphorylase 0.0111 0.2888 0.2923
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.2888 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.4216 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0176 0.0568
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.014 0.0328
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0161 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0338 0.0249
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.3561 0.3502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0161 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Schistosoma mansoni hypothetical protein 0.0042 0.0851 0.0794
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.014 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0176 0.0166
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0161 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.4032 0.9554
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.014 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0141 0.0335
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0125 0.0081
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0161 0.1025
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0338 1
Brugia malayi hypothetical protein 0.0156 0.4216 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0951 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.2611 0.8997
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1152 0.7163
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.1027 0.3266
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.014 0.0328
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0176 0.0204
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.3561 0.3502
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.014 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.014 0.0328
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0161 0.0744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0951 0.0867
Echinococcus multilocularis protein dispatched 1 0.005 0.108 0.0997
Onchocerca volvulus 0.0156 0.4216 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1572 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.1009 0.0926
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.014 0.0328
Giardia lamblia DINP protein human, muc B family 0.0019 0.0176 0.0129
Giardia lamblia Glycogen phosphorylase 0.0111 0.2888 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.014 0.0051
Leishmania major cathepsin L-like protease 0.0017 0.0125 0.0225
Entamoeba histolytica hypothetical protein 0.0037 0.0707 0.2106
Schistosoma mansoni hypothetical protein 0.0037 0.0707 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Schistosoma mansoni glycogen phosphorylase 0.0048 0.1027 0.0978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0951 0.0898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Loa Loa (eye worm) ctsf protein 0.0017 0.0125 0.0081
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.014 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.2888 0.2823
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0176 0.1117
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0125 0.0034
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.014 0.1967
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0125 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0161 0.5
Echinococcus granulosus GPCR family 2 0.0047 0.1009 0.0926
Echinococcus granulosus dna polymerase kappa 0.0019 0.0176 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.2888 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1572 1
Chlamydia trachomatis glycogen phosphorylase 0.0111 0.2888 0.5
Schistosoma mansoni hypothetical protein 0.0102 0.2633 0.2656
Loa Loa (eye worm) hypothetical protein 0.0053 0.1188 0.2657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0951 0.0898
Onchocerca volvulus 0.0051 0.1131 0.2459
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0951 0.2083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0125 0.0034
Leishmania major cathepsin L-like protease 0.0066 0.1572 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.1009 0.0926
Plasmodium vivax vivapain-2 0.0017 0.0125 0.4774
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.014 0.0049
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.014 0.0891
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0338 0.2151
Entamoeba histolytica hypothetical protein 0.0037 0.0707 0.2106
Leishmania major cathepsin L-like protease 0.0017 0.0125 0.0225
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.014 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0176 0.0568
Echinococcus granulosus glycogen phosphorylase 0.0111 0.2888 0.2823
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0898 0.1955
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0176 0.0568
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0951 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.3899 0.3843
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.2888 0.2823
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1572 1
Echinococcus granulosus geminin 0.034 0.9659 0.9656
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0125 0.4774
Echinococcus multilocularis tumor protein p63 0.0351 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.1009 0.0959
Loa Loa (eye worm) hypothetical protein 0.0051 0.1131 0.2519
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.014 0.0891
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0176 0.1117
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0161 0.0169
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.014 0.0328
Leishmania major DNA polymerase kappa, putative 0.0019 0.0176 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Echinococcus multilocularis cysteine protease 0.0017 0.0125 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Loa Loa (eye worm) cysteine protease 0.0017 0.0125 0.0081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0338 0.0598
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0176 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0236 0.0976
Schistosoma mansoni P2X receptor subunit 0.0134 0.3561 0.3626
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0161 0.0471
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0161 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Entamoeba histolytica hypothetical protein 0.0037 0.0707 0.2106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.014 0.0118
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.2888 0.678
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.014 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.1027 0.3266
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0176 0.0184
Schistosoma mansoni ap endonuclease 0.0019 0.0161 0.0073
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0176 0.0088
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0176 0.1117
Schistosoma mansoni hypothetical protein 0.0042 0.0851 0.0794
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0125 0.0081
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0176 0.0204
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0161 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0338 0.0249
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.1027 1
Brugia malayi CHE-14 protein 0.0044 0.0898 0.1955
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.3899 0.3843
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.014 0.0891
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0176 0.0898
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0141 0.0335
Loa Loa (eye worm) fibroinase 0.0017 0.0125 0.0081
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.3561 0.3502
Echinococcus granulosus expressed conserved protein 0.0095 0.2429 0.2359
Schistosoma mansoni patched 1 0.0044 0.0898 0.0843
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.2658 0.2682
Schistosoma mansoni glycogen phosphorylase 0.0111 0.2888 0.2923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0707 0.0621
Plasmodium vivax vivapain-2 0.0017 0.0125 0.4774
Schistosoma mansoni hypothetical protein 0.0047 0.1009 0.0959
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.4032 0.9554
Leishmania major cathepsin L-like protease 0.0066 0.1572 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.014 0.0118
Echinococcus multilocularis GPCR, family 2 0.0047 0.1009 0.0926
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0176 0.0568
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0176 0.0184
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.2888 0.2823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0951 0.0867
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0161 0.007
Schistosoma mansoni hypothetical protein 0.034 0.9659 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0176 0.0088
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0125 0.0034
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0092 0.0582
Echinococcus multilocularis cysteine protease 0.0017 0.0125 0.0034
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.2611 0.6109
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0125 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.2633 0.6162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0338 0.0772
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0582
Loa Loa (eye worm) hypothetical protein 0.0044 0.0898 0.1955
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.1401 0.885
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0898 0.0814
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0176 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0176 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0125 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0161 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0125 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.2888 0.2823
Echinococcus granulosus glycogen phosphorylase 0.0111 0.2888 0.2823
Entamoeba histolytica hypothetical protein 0.0037 0.0707 0.2106
Toxoplasma gondii exonuclease III APE 0.0019 0.0161 0.2825
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.1009 0.2225
Trypanosoma brucei unspecified product 0.0019 0.0176 0.1117
Entamoeba histolytica hypothetical protein 0.0025 0.0338 0.0772
Schistosoma mansoni ap endonuclease 0.0019 0.0161 0.0073
Echinococcus granulosus dna polymerase eta 0.0019 0.0176 0.0085
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0161 0.0169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0176 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus multilocularis p2X purinoceptor 4 0.0134 0.3561 0.3502
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0161 0.5
Echinococcus multilocularis expressed conserved protein 0.0095 0.2429 0.2359
Schistosoma mansoni hypothetical protein 0.0042 0.0851 0.0794
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.014 0.0118
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1572 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0176 0.0568
Leishmania major cathepsin L-like protease 0.0017 0.0125 0.0225
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.014 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1572 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.2888 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.1009 0.2225
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.014 0.0328
Schistosoma mansoni P2X receptor subunit 0.0134 0.3561 0.3626
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0176 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0125 0.0081
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0176 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.014 0.0049
Brugia malayi hypothetical protein 0.0037 0.0707 0.1491
Echinococcus granulosus p2X purinoceptor 4 0.0134 0.3561 0.3502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0951 0.0898
Schistosoma mansoni P2X receptor subunit 0.0134 0.3561 0.3626
Brugia malayi Cathepsin L-like precursor 0.0017 0.0125 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0161 0.0132
Schistosoma mansoni hypothetical protein 0.0042 0.0851 0.0794
Brugia malayi carbohydrate phosphorylase 0.0111 0.2888 0.678
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.2633 0.6162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.1009 0.0926
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0125 0.4774
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.2888 0.6754
Schistosoma mansoni hypothetical protein 0.034 0.9659 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.014 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0338 0.1665
Echinococcus multilocularis geminin 0.034 0.9659 0.9656
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0707 0.0643
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0176 0.0568
Schistosoma mansoni hypothetical protein 0.0047 0.1009 0.0959
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0176 0.0204
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0161 0.0471
Leishmania major cathepsin L-like protease 0.0066 0.1572 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.2611 0.2543
Brugia malayi Latrophilin receptor protein 2 0.0047 0.1009 0.2225
Toxoplasma gondii cathepsin CPL 0.0017 0.0125 0.1349
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0176 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0125 0.0034
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.2888 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0176 0.1117
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0161 0.0077
Schistosoma mansoni hypothetical protein 0.0047 0.1009 0.0959
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.014 0.0055
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0125 0.0035
Echinococcus multilocularis protein patched 0.0044 0.0898 0.0814

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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