TDR Targets

Basic information

Technical information

TDR Targets ID: 629614
Name: 5-chloro-4-(4-methylphenyl)sulfonyl-2-(phenyl methylsulfonyl)-1,3-thiazole
MW: 427.945 | Formula: C17H14ClNO4S3
H donors: 0 H acceptors: 5 LogP: 4.47 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)c1nc(sc1Cl)S(=O)(=O)Cc1ccccc1
InChi: 1S/C17H14ClNO4S3/c1-12-7-9-14(10-8-12)26(22,23)16-15(18)24-17(19-16)25(20,21)11-13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChiKey: FWSUPOBPIYOYGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-chloro-4-(4-methylphenyl)sulfonyl-2-(phenylmethylsulfonyl)thiazole
2-(benzylsulfonyl)-5-chloro-4-(4-methylphenyl)sulfonyl-thiazole
ZINC02709067

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphofructokinase, putative	0.0112	0.122	0.7367
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0818
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0141	0.159	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0738	0.0738
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.01	0.0631
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.01	0.0818
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.01	0.0818
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0738	0.3936
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0067	0.0653	0.111
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0185	0.2248
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0141	0.159	1
Echinococcus multilocularis	6 phosphofructokinase	0.0112	0.122	0.122
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0042	0.0339	0.0603
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0042	0.0339	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Echinococcus multilocularis	geminin	0.0176	0.2033	0.2033
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Echinococcus multilocularis	neuropeptide s receptor	0.0458	0.5617	0.5617
Brugia malayi	6-phosphofructokinase	0.0112	0.122	1
Entamoeba histolytica	phosphofructokinase, putative	0.0112	0.122	1
Onchocerca volvulus		0.0074	0.0738	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0818
Mycobacterium ulcerans	lipase LipD	0.0074	0.0738	0.5967
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0075	0.0753	0.5829
Schistosoma mansoni	eyes absent homolog	0.0093	0.0984	0.4842
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0035	0.0248	0.0453
Mycobacterium ulcerans	6-phosphofructokinase	0.0112	0.122	1
Trichomonas vaginalis	esterase, putative	0.0074	0.0738	0.3936
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	0.5617	0.5617
Brugia malayi	phosphofructokinase	0.0112	0.122	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0141	0.159	1
Leishmania major	hypothetical protein, conserved	0.0074	0.0738	0.5696
Trichomonas vaginalis	phosphofructokinase, putative	0.0112	0.122	0.7367
Echinococcus granulosus	geminin	0.0176	0.2033	0.362
Echinococcus granulosus	neuropeptide receptor A26	0.0458	0.5617	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Echinococcus granulosus	neuropeptide s receptor	0.0458	0.5617	1
Schistosoma mansoni	inositol monophosphatase	0.0075	0.0753	0.3701
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Brugia malayi	beta-lactamase family protein	0.0074	0.0738	0.6048
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0042	0.0339	0.2778
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0738	0.5696
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Schistosoma mansoni	hypothetical protein	0.0176	0.2033	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0141	0.159	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0075	0.0753	1
Brugia malayi	Inositol-1	0.0075	0.0753	0.617
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0738	0.1313
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.02
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0042	0.0339	0.0339
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0738	0.1257
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0738	0.3628
Schistosoma mansoni	6-phosphofructokinase	0.0112	0.122	0.5999
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0738	0.6048
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0112	0.122	1
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0738	1
Schistosoma mansoni	hypothetical protein	0.0034	0.023	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Brugia malayi	6-phosphofructokinase	0.0112	0.122	1
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0738	0.1257
Trichomonas vaginalis	inositol monophosphatase, putative	0.0075	0.0753	0.4041
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.01	0.0152
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.01	0.0631
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0075	0.0753	0.0308
Echinococcus granulosus	6 phosphofructokinase	0.0112	0.122	0.2171
Giardia lamblia	NADPH oxidoreductase, putative	0.0141	0.159	1
Loa Loa (eye worm)	inositol-1	0.0075	0.0753	0.617
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0112	0.122	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0984	0.8071
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0471	0.5782	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0112	0.122	0.2155
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0075	0.0753	0.5829
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0112	0.122	1
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0042	0.0339	0.2778
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0429	0.3514
Treponema pallidum	ATP-binding protein (ylxH-1)	0.0408	0.4988	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.0185	0.0759
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0738	0.3628
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0075	0.0753	0.6092
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0075	0.0753	0.0308
Brugia malayi	hypothetical protein	0.0093	0.0984	0.8071
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.1143	0.682
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0738	0.5967
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0024	0.0021
Onchocerca volvulus		0.0074	0.0738	1
Schistosoma mansoni	hypothetical protein	0.0176	0.2033	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0185	1
Leishmania major	ATP-dependent phosphofructokinase	0.0112	0.122	1
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0035	0.0248	0.1327
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0112	0.122	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0042	0.0339	0.1667
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0738	0.1257
Loa Loa (eye worm)	transcription factor SMAD2	0.011	0.1204	0.987
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0075	0.0753	0.5
Mycobacterium ulcerans	hypothetical protein	0.0023	0.01	0.0631
Schistosoma mansoni	6-phosphofructokinase	0.0112	0.122	0.5999
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.02
Echinococcus granulosus	inositol monophosphatase 1	0.0075	0.0753	0.134
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.01	0.0631
Loa Loa (eye worm)	phosphofructokinase	0.0112	0.122	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0738	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0738	0.6048
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0738	0.5967
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0738	0.5967
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0034	0.023	0.1887
Entamoeba histolytica	phosphofructokinase, putative	0.0112	0.122	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0075	0.0753	0.0308
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0042	0.0339	0.0339
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0429	0.3514
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0075	0.0753	0.4041
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.01	0.0152
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0738	0.6048
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Loa Loa (eye worm)	MH2 domain-containing protein	0.011	0.1204	0.987
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Echinococcus multilocularis	inositol monophosphatase 1	0.0075	0.0753	0.0753
Trichomonas vaginalis	phosphofructokinase, putative	0.0112	0.122	0.7367
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0738	0.3936
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0042	0.0339	0.0603
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0141	0.159	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.01	0.0631
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0738	0.5967
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Loa Loa (eye worm)	6-phosphofructokinase	0.0112	0.122	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0738	0.3936
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0738	0.1257
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0738	0.1257
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0429	0.3514
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.023	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0818
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0738	0.3936
Brugia malayi	beta-lactamase	0.0074	0.0738	0.6048
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0738	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0984	0.8071
Onchocerca volvulus		0.0074	0.0738	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0248	0.0453
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.01	0.0818
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0185	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0075	0.0753	0.4041
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0185	1
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0185	0.2248
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.02
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0035	0.0248	0.1327
Brugia malayi	MH2 domain containing protein	0.011	0.1204	0.987
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0738	0.3936
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.01	0.0631
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.01	0.0631
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0042	0.0339	0.1667
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0738	0.1257
Toxoplasma gondii	ABC1 family protein	0.0074	0.0738	0.9738
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0067	0.0653	0.4939
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0738	0.1257
Entamoeba histolytica	phosphofructokinase, putative	0.0112	0.122	1
Brugia malayi	beta-lactamase family protein	0.0074	0.0738	0.6048
Trichomonas vaginalis	phosphofructokinase, putative	0.0112	0.122	0.7367
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Schistosoma mansoni	inositol monophosphatase	0.0075	0.0753	0.3701
Entamoeba histolytica	hypothetical protein	0.0035	0.0248	0.1327
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0738	0.5696
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0738	0.6048
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.01	0.0631
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.159	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0429	0.3514
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0185	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0035	0.0248	0.0453
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0738	0.1257
Loa Loa (eye worm)	6-phosphofructokinase	0.0112	0.122	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 629614