Detailed information for compound 630847

Basic information

Technical information
  • TDR Targets ID: 630847
  • Name: N-(2-chlorophenyl)-2-[(5Z)-5-[(4-methoxypheny l)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl ]acetamide
  • MW: 402.851 | Formula: C19H15ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=C1SC(=O)N(C1=O)CC(=O)Nc1ccccc1Cl
  • InChi: 1S/C19H15ClN2O4S/c1-26-13-8-6-12(7-9-13)10-16-18(24)22(19(25)27-16)11-17(23)21-15-5-3-2-4-14(15)20/h2-10H,11H2,1H3,(H,21,23)/b16-10-
  • InChiKey: IPVUPBAHDKULQD-YBEGLDIGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chlorophenyl)-2-[5-[(4-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
  • N-(2-chlorophenyl)-2-[(5Z)-5-[(4-methoxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetamide
  • N-(2-chlorophenyl)-2-[5-[(4-methoxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetamide
  • N-(2-chlorophenyl)-2-[5-[(4-methoxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetamide
  • N-(2-chlorophenyl)-2-[(5Z)-5-[(4-methoxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetamide
  • N-(2-chlorophenyl)-2-[(5Z)-2,4-diketo-5-(4-methoxybenzylidene)thiazolidin-3-yl]acetamide
  • N-(2-chlorophenyl)-2-[2,4-diketo-5-(4-methoxybenzylidene)thiazolidin-3-yl]acetamide
  • N-(2-chlorophenyl)-2-[(5Z)-5-[(4-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanamide
  • N-(2-chlorophenyl)-2-[5-[(4-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanamide
  • BIM-0023297.P001
  • BAS 00570033
  • ZINC01245378
  • CBMicro_023200

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0019 0.001 0.0007
Trypanosoma brucei telomerase reverse transcriptase 0.1621 0.2715 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0078 0.0256
Giardia lamblia Telomerase catalytic subunit 0.1621 0.2715 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0078 0.0309
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1348 0.2253 1
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0119 0.0492
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0449 0.1962
Plasmodium vivax glycogen synthase kinase 3, putative 0.1348 0.2253 0.8294
Trypanosoma brucei unspecified product 0.0019 0.001 0.0037
Schistosoma mansoni hypothetical protein 0.0081 0.0114 0.0469
Echinococcus multilocularis dna polymerase eta 0.0019 0.001 0.0007
Plasmodium vivax telomerase reverse transcriptase, putative 0.1621 0.2715 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0009 0.5
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0119 0.0492
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.001 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0078 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.1348 0.2253 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0078 0.0256
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0084 0.0334
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1621 0.2715 1
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0119 0.0492
Echinococcus multilocularis expressed conserved protein 0.0184 0.0287 0.1242
Echinococcus granulosus dna polymerase kappa 0.0019 0.001 0.0007
Echinococcus granulosus protein kinase shaggy 0.1348 0.2253 1
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0084 0.0334
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Entamoeba histolytica protein kinase, putative 0.0063 0.0084 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0103 0.0151 0.0634
Loa Loa (eye worm) hypothetical protein 0.015 0.0231 0.099
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0063 0.0084 0.0371
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0063 0.0084 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0063 0.0084 0.0371
Leishmania major DNA polymerase kappa, putative 0.0019 0.001 0.0006
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0084 0.0334
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0084 0.0334
Plasmodium falciparum glycogen synthase kinase 3 0.1348 0.2253 0.8294
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.001 0.0045
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.001 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.001 0.0037
Echinococcus multilocularis dna polymerase kappa 0.0019 0.001 0.0007
Brugia malayi Muscleblind-like protein 0.015 0.0231 0.0306
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0009 0.5
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1348 0.2253 0.8294
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0084 0.0334
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1348 0.2253 0.8294
Brugia malayi serine/threonine-protein kinase 6 0.0063 0.0084 0.0103
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.0031
Toxoplasma gondii RNA-directed DNA polymerase 0.1621 0.2715 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.001 0.0007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0313 0.1354
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0449 0.1962
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0078 0.0309
Leishmania major protein kinase, putative 0.0063 0.0084 0.0277
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0063 0.0084 0.0277
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0119 0.0492
Echinococcus granulosus muscleblind protein 0.015 0.0231 0.099
Plasmodium falciparum serine/threonine protein kinase, putative 0.0063 0.0084 0.0277
Schistosoma mansoni protein kinase 0.0063 0.0084 0.0334
Echinococcus multilocularis protein dispatched 1 0.0096 0.0139 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Echinococcus granulosus expressed conserved protein 0.0184 0.0287 0.1242
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1348 0.2253 1
Leishmania major DNA polymerase eta, putative 0.0019 0.001 0.0006
Giardia lamblia Kinase, CMGC GSK 0.1348 0.2253 0.8294
Trypanosoma cruzi aurora B kinase, putative 0.0063 0.0084 0.0277
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0009 0.0038
Schistosoma mansoni hypothetical protein 0.0081 0.0114 0.0469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0006
Entamoeba histolytica protein kinase domain containing protein 0.1348 0.2253 1
Trichomonas vaginalis CMGC family protein kinase 0.1348 0.2253 1
Leishmania major telomerase reverse transcriptase, putative 0.1621 0.2715 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1621 0.2715 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0007
Giardia lamblia Kinase, CMGC GSK 0.1348 0.2253 0.8294
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.001 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0195 0.0307 0.1331
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1348 0.2253 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.001 0.0007
Echinococcus multilocularis muscleblind protein 0.015 0.0231 0.099
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0078 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.001 0.0233
Entamoeba histolytica protein kinase domain containing protein 0.1348 0.2253 1
Plasmodium falciparum telomerase reverse transcriptase 0.1621 0.2715 1
Brugia malayi intracellular kinase 0.1348 0.2253 0.3095
Brugia malayi Telomerase reverse transcriptase 0.4314 0.7262 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0037
Entamoeba histolytica protein kinase , putative 0.0063 0.0084 0.0371
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0084 0.0334
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0084 0.0334
Echinococcus multilocularis protein patched 0.0084 0.0119 0.0492
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.001 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0084 0.0334
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0307 0.1364
Trypanosoma brucei protein kinase, putative 0.1348 0.2253 0.83
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0081 0.0114 0.0469
Loa Loa (eye worm) hypothetical protein 0.015 0.0231 0.099
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0063 0.0084 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1348 0.2253 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.001 0.0007
Echinococcus granulosus aurora kinase A 0.0063 0.0084 0.0334
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0078 1
Echinococcus multilocularis muscleblind protein 1 0.015 0.0231 0.099
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0084 0.0371
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0078 1
Giardia lamblia Aurora kinase 0.0063 0.0084 0.0277
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0078 0.0309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0081 0.0114 0.0469
Brugia malayi serine/threonine protein kinase 6 0.0063 0.0084 0.0103
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0307 0.0412
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0119 0.0492
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0307 0.1331
Echinococcus multilocularis protein kinase shaggy 0.1348 0.2253 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0063 0.0084 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1348 0.2253 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.001 0.0037
Trypanosoma brucei aurora B kinase 0.0063 0.0084 0.0308
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0078 0.0309
Echinococcus granulosus microtubule associated protein 2 0.0676 0.112 0.4949
Echinococcus multilocularis aurora kinase A 0.0063 0.0084 0.0334
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.001 0.0002
Entamoeba histolytica protein kinase, putative 0.0063 0.0084 0.0371
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.112 0.4949
Brugia malayi serine/threonine kinase 12 0.0063 0.0084 0.0103
Entamoeba histolytica protein kinase, putative 0.1348 0.2253 1
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.112 0.4949
Schistosoma mansoni patched 1 0.0084 0.0119 0.0492
Giardia lamblia DINP protein human, muc B family 0.0019 0.001 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.001 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0307 0.1331
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.001 0.0233
Brugia malayi CHE-14 protein 0.0084 0.0119 0.0152
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1348 0.2253 0.8294
Loa Loa (eye worm) hypothetical protein 0.0084 0.0119 0.0492
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.001 0.0037
Toxoplasma gondii aurora kinase 0.0063 0.0084 0.0277

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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