Detailed information for compound 63799

Basic information

Technical information
  • TDR Targets ID: 63799
  • Name: 2-trimethylsilylethyl acetate
  • MW: 160.286 | Formula: C7H16O2Si
  • H donors: 0 H acceptors: 1 LogP: 2.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCC[Si](C)(C)C
  • InChi: 1S/C7H16O2Si/c1-7(8)9-5-6-10(2,3)4/h5-6H2,1-4H3
  • InChiKey: LZQFCHRCTZAAER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid 2-trimethylsilylethyl ester
  • 2-trimethylsilylethyl ethanoate
  • 2-(trimethylsilyl)ethyl acetate
  • 16046-10-9
  • EINECS 240-189-9
  • Ethanol, 2-(trimethylsilyl)-, acetate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sex peptide receptor 0.0566 0.2446 0.2152
Echinococcus granulosus beta tubulin 0.0617 0.27 0.2416
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Echinococcus multilocularis sodium channel protein 0.0443 0.1837 0.152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Onchocerca volvulus 0.0148 0.0374 0.1528
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0566 0.2446 0.4363
Echinococcus granulosus neuropeptide Y receptor 0.0566 0.2446 0.2152
Echinococcus granulosus peptide allatostatin:somatostatin 0.0566 0.2446 0.2152
Echinococcus granulosus allatostatin A receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Onchocerca volvulus 0.0155 0.0406 0.1662
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis g protein coupled receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0617 0.27 0.2416
Brugia malayi ORL1-like opioid receptor 0.0566 0.2446 0.3548
Echinococcus multilocularis dro:myosuppressin receptor 0.0566 0.2446 0.2152
Plasmodium vivax tubulin beta chain, putative 0.0617 0.27 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Trypanosoma brucei beta tubulin 0.0617 0.27 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.0617 0.27 0.2416
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) G-protein coupled receptor 0.0566 0.2446 0.7022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Brugia malayi RE15519p 0.0566 0.2446 0.3548
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0566 0.2446 0.2152
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni opsin-like receptor 0.0566 0.2446 0.4363
Echinococcus granulosus integrin beta 2 0.0499 0.2113 0.1806
Echinococcus granulosus Tubulin beta 2C chain 0.0617 0.27 0.2416
Echinococcus granulosus G protein coupled receptor 139 0.0566 0.2446 0.2152
Echinococcus multilocularis neuropeptide Y receptor 0.0566 0.2446 0.2152
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0155 0.0406 0.1167
Echinococcus multilocularis g protein coupled receptor 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Schistosoma mansoni hypothetical protein 0.0148 0.0374 0.0439
Toxoplasma gondii beta-1 tubulin, putative 0.0617 0.27 0.5
Brugia malayi beta-tubulin, identical 0.0617 0.27 0.3916
Schistosoma mansoni biogenic amine receptor 0.0566 0.2446 0.4363
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0566 0.2446 0.4363
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0566 0.2446 0.2152
Echinococcus multilocularis fmrfamide receptor 0.0566 0.2446 0.2152
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0176 0.0227
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0429 0.1766 0.7218
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0566 0.2446 0.7022
Loa Loa (eye worm) neuropeptide F receptor 0.0566 0.2446 0.7022
Echinococcus granulosus g protein coupled receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0102 0.0147 0.0421
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0566 0.2446 0.2152
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0155 0.0406 0.1662
Echinococcus granulosus biogenic amine 5HT receptor 0.0566 0.2446 0.2152
Leishmania major beta tubulin 0.0617 0.27 1
Trichomonas vaginalis tubulin, putative 0.0617 0.27 1
Trichomonas vaginalis amylase, putative 0.0108 0.0176 0.0227
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0149 0.0376 0.108
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Echinococcus multilocularis Tubulin beta 2C chain 0.0617 0.27 0.2416
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0566 0.2446 0.2152
Brugia malayi G protein-coupled receptor F59B2.13 0.0566 0.2446 0.3548
Schistosoma mansoni growth hormone secretagogue receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) G-protein coupled receptor 0.0566 0.2446 0.7022
Brugia malayi Dopamine receptor 0.0566 0.2446 0.3548
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0566 0.2446 0.2152
Trypanosoma cruzi beta tubulin, putative 0.0617 0.27 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis beta tubulin 0.0617 0.27 0.2416
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) BEN-1 protein 0.0617 0.27 0.775
Echinococcus multilocularis Tubulin beta 2C chain 0.0617 0.27 0.2416
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) integrin beta-2 0.0578 0.2507 0.7195
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Schistosoma mansoni hypothetical protein 0.0566 0.2446 0.4363
Schistosoma mansoni amine GPCR 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Schistosoma mansoni myosin xvIII 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi G protein-coupled receptor 0.0566 0.2446 0.3548
Brugia malayi AKH receptor 0.0566 0.2446 0.3548
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0176 0.0227
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0566 0.2446 0.2152
Brugia malayi Serotonin receptor 0.0566 0.2446 0.3548
Echinococcus multilocularis neuropeptide FF receptor 2 0.0566 0.2446 0.2152
Brugia malayi neuropeptide F receptor 0.0566 0.2446 0.3548
Echinococcus granulosus Tubulin beta 2C chain 0.0617 0.27 0.2416
Brugia malayi GnHR receptor homolog 0.1463 0.6895 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0566 0.2446 0.2152
Brugia malayi Dopamine receptor protein 2 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0566 0.2446 0.4363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0566 0.2446 0.7022
Brugia malayi Tubulin beta-1 chain 0.0617 0.27 0.3916
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Onchocerca volvulus 0.0566 0.2446 1
Schistosoma mansoni amine GPCR 0.0566 0.2446 0.4363
Schistosoma mansoni neuropeptide receptor 0.0566 0.2446 0.4363
Echinococcus granulosus tm gpcr rhodopsin 0.0566 0.2446 0.2152
Loa Loa (eye worm) tubulin beta-1 chain 0.0617 0.27 0.775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Brugia malayi A-macroglobulin complement component family protein 0.016 0.0432 0.0627
Schistosoma mansoni neuropeptide F-like receptor 0.0566 0.2446 0.4363
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Loa Loa (eye worm) hypothetical protein 0.0422 0.1733 0.4975
Echinococcus multilocularis alpha 2 macroglobulin 0.016 0.0432 0.006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0566 0.2446 0.3548
Echinococcus granulosus Tubulin beta 2C chain 0.0617 0.27 0.2416
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0566 0.2446 0.4363
Schistosoma mansoni hypothetical protein 0.0566 0.2446 0.4363
Schistosoma mansoni alpha-1 adrenergic receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0163 0.0446 0.128
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0566 0.2446 0.7022
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni opsin-like receptor 0.0566 0.2446 0.4363
Trypanosoma brucei beta tubulin 0.0617 0.27 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) A-macroglobulin complement component family protein 0.016 0.0432 0.124
Loa Loa (eye worm) beta-tubulin 0.0617 0.27 0.775
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0566 0.2446 0.3548
Trichomonas vaginalis tubulin epsilon chain, putative 0.0617 0.27 1
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Echinococcus multilocularis serotonin receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis Tubulin beta 2C chain 0.0617 0.27 0.2416
Schistosoma mansoni neuropeptide F-like receptor 0.0566 0.2446 0.4363
Echinococcus granulosus somatostatin receptor 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0262 0.0938 0.3834
Echinococcus granulosus Tubulin beta 2C chain 0.0617 0.27 0.2416
Giardia lamblia Beta tubulin 0.0617 0.27 0.5
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Trichomonas vaginalis amylase, putative 0.0108 0.0176 0.0227
Leishmania major beta tubulin 0.0617 0.27 1
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0176 0.0227
Onchocerca volvulus 0.0566 0.2446 1
Schistosoma mansoni hypothetical protein 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0566 0.2446 0.2152
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus multilocularis allatostatin A receptor 0.0566 0.2446 0.2152
Schistosoma mansoni biogenic amine receptor 0.0566 0.2446 0.4363
Echinococcus granulosus neuropeptide receptor 0.1166 0.5422 0.5244
Schistosoma mansoni amine GPCR 0.0566 0.2446 0.4363
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0566 0.2446 0.2152
Trichomonas vaginalis tubulin beta chain, putative 0.0617 0.27 1
Brugia malayi Dopamine receptor protein 1 0.0566 0.2446 0.3548
Echinococcus granulosus neuropeptides capa receptor 0.0566 0.2446 0.2152
Entamoeba histolytica tubulin family protein 0.0617 0.27 1
Echinococcus granulosus fmrfamide receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) neuropeptide F receptor 0.0566 0.2446 0.7022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Trichomonas vaginalis tubulin alpha chain, putative 0.0617 0.27 1
Brugia malayi neuropeptide F receptor 0.0566 0.2446 0.3548
Loa Loa (eye worm) tubulin beta-4 chain 0.0617 0.27 0.775
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis orexin receptor type 2 0.0566 0.2446 0.2152
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) BEN-1 protein 0.0617 0.27 0.775
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis tubulin beta 1 chain 0.0617 0.27 0.2416
Schistosoma mansoni histamine h1 receptor 0.0566 0.2446 0.4363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni adenoreceptor 0.0566 0.2446 0.4363
Echinococcus granulosus g protein coupled receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis neuropeptide receptor A26 0.0566 0.2446 0.2152
Giardia lamblia Beta tubulin 0.0617 0.27 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0566 0.2446 0.2152
Echinococcus granulosus neuropeptide receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) tubulin beta chain 0.0617 0.27 0.775
Echinococcus granulosus neuropeptide s receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis neuropeptide s receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis neuropeptide receptor 0.1166 0.5422 0.5244
Echinococcus multilocularis integrin beta 2 0.0499 0.2113 0.1806
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus granulosus hypothetical protein 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Onchocerca volvulus 0.0566 0.2446 1
Schistosoma mansoni integrin beta subunit 0.0396 0.1606 0.2771
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus multilocularis sex peptide receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2089 1 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Toxoplasma gondii beta-tubulin, putative 0.0617 0.27 0.5
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Brugia malayi Integrin beta pat-3 precursor 0.0578 0.2507 0.3635
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis neuropeptide receptor 0.0566 0.2446 0.2152
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) tubulin beta-2A chain 0.0617 0.27 0.775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Echinococcus multilocularis serotonin receptor 0.0566 0.2446 0.2152
Schistosoma mansoni macroglobulin/complement 0.016 0.0432 0.0548
Brugia malayi Tachykinin-like peptides receptor 99D 0.0566 0.2446 0.3548
Trypanosoma brucei beta tubulin 0.0617 0.27 0.5
Schistosoma mansoni opsin-like receptor 0.0566 0.2446 0.4363
Brugia malayi sulfakinin receptor protein 0.0775 0.3484 0.5052
Echinococcus multilocularis beta tubulin 0.0617 0.27 0.2416
Schistosoma mansoni amine GPCR 0.0566 0.2446 0.4363
Schistosoma mansoni neuropeptide receptor 0.1166 0.5422 1
Echinococcus granulosus neuropeptides capa receptor 0.0566 0.2446 0.2152
Echinococcus multilocularis adenylate cyclase 9 0.0155 0.0406 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0566 0.2446 0.2152
Onchocerca volvulus Neuropeptide F receptor homolog 0.0566 0.2446 1
Schistosoma mansoni amine GPCR 0.0566 0.2446 0.4363
Echinococcus granulosus sodium channel protein 0.0443 0.1837 0.152
Loa Loa (eye worm) hypothetical protein 0.0775 0.3484 1
Echinococcus granulosus g protein coupled receptor 0.0566 0.2446 0.2152
Brugia malayi G-protein coupled receptor 0.0566 0.2446 0.3548
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Toxoplasma gondii beta tubulin 0.0617 0.27 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.0617 0.27 0.2416
Echinococcus multilocularis g protein coupled receptor 0.0566 0.2446 0.2152
Trichomonas vaginalis tubulin gamma chain, putative 0.0617 0.27 1
Brugia malayi Serotonin receptor 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0376 0.0546
Schistosoma mansoni biogenic amine (5HT) receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) melatonin receptor type 1A 0.0566 0.2446 0.7022
Echinococcus granulosus biogenic amine 5HT receptor 0.0566 0.2446 0.2152
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0566 0.2446 0.4363
Brugia malayi Protein kinase domain containing protein 0.0168 0.0472 0.0684
Onchocerca volvulus 0.0566 0.2446 1
Brugia malayi hypothetical protein 0.0775 0.3484 0.5052
Echinococcus granulosus Tubulin beta 2C chain 0.0617 0.27 0.2416
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Giardia lamblia Beta tubulin 0.0617 0.27 0.5
Schistosoma mansoni hypothetical protein 0.0566 0.2446 0.4363
Echinococcus multilocularis G-protein coupled receptor, putative 0.0566 0.2446 0.2152
Schistosoma mansoni neuropeptide f receptor 76f 0.0566 0.2446 0.4363
Echinococcus multilocularis somatostatin receptor 0.0566 0.2446 0.2152
Echinococcus granulosus beta tubulin 0.0617 0.27 0.2416
Plasmodium falciparum tubulin beta chain 0.0617 0.27 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Loa Loa (eye worm) adenylyl cyclase 3 0.0155 0.0406 0.1167
Echinococcus multilocularis neuropeptides capa receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus granulosus neuropeptide FF receptor 2 0.0566 0.2446 0.2152
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Brugia malayi Adenylyl cyclase protein 0.0155 0.0406 0.059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0376 0.108
Trichomonas vaginalis alpha-amylase, putative 0.0108 0.0176 0.0227
Brugia malayi follicle stimulating hormone receptor 0.0566 0.2446 0.3548
Echinococcus multilocularis Tubulin beta 2C chain 0.0617 0.27 0.2416
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0443 0.1837 0.152
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0566 0.2446 0.2152
Schistosoma mansoni neuropeptide receptor 0.0566 0.2446 0.4363
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0566 0.2446 0.4363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Brugia malayi Angiotensin-converting enzyme family protein 0.0163 0.0446 0.0647
Echinococcus granulosus adenylate cyclase 9 0.0155 0.0406 0.0033
Echinococcus granulosus 7tm_1 domain containing protein 0.0566 0.2446 0.2152
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0566 0.2446 0.3548
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus granulosus neuropeptide receptor A26 0.0566 0.2446 0.2152
Brugia malayi Kelch motif family protein 0.0102 0.0147 0.0213
Brugia malayi Melatonin receptor type 1A 0.0566 0.2446 0.3548
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0566 0.2446 0.7022
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0102 0.0147 0.0421
Onchocerca volvulus 0.0566 0.2446 1
Brugia malayi putative neuropeptide receptor 0.0566 0.2446 0.3548
Leishmania major beta tubulin 0.0617 0.27 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0566 0.2446 0.4363
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus multilocularis fmrfamide receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus granulosus tubulin subunit beta 0.0617 0.27 0.2416
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0566 0.2446 0.3548
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0566 0.2446 0.2152
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Echinococcus granulosus g-protein coupled receptor 0.0566 0.2446 0.2152
Echinococcus granulosus orexin receptor type 2 0.0566 0.2446 0.2152
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi G-protein coupled receptor 0.0566 0.2446 0.3548
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0566 0.2446 0.3548
Loa Loa (eye worm) hypothetical protein 0.0168 0.0472 0.1354
Echinococcus granulosus rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Schistosoma mansoni neuropeptide receptor 0.0566 0.2446 0.4363
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Echinococcus multilocularis g-protein coupled receptor 0.0566 0.2446 0.2152
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0566 0.2446 0.7022
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0143 0.0207
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0376 0.0546
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0566 0.2446 1
Leishmania major beta tubulin 0.0617 0.27 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0566 0.2446 0.4363
Schistosoma mansoni biogenic amine receptor 0.0566 0.2446 0.4363
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus granulosus serotonin receptor 0.0566 0.2446 0.2152
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0566 0.2446 0.2152
Leishmania major beta tubulin 0.0617 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0566 0.2446 0.4363
Echinococcus multilocularis neuropeptide Y receptor 0.0566 0.2446 0.2152
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0566 0.2446 0.4363
Loa Loa (eye worm) hypothetical protein 0.0566 0.2446 0.7022
Schistosoma mansoni tubulin subunit beta 0.0617 0.27 0.4844
Onchocerca volvulus 0.0566 0.2446 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0617 0.27 1
Echinococcus multilocularis tubulin subunit beta 0.0617 0.27 0.2416
Leishmania major beta tubulin 0.0617 0.27 1
Echinococcus granulosus tubulin beta 1 chain 0.0617 0.27 0.2416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0566 0.2446 0.4363
Brugia malayi hypothetical protein 0.0102 0.0147 0.0213
Trypanosoma brucei beta tubulin 0.0617 0.27 0.5
Brugia malayi hypothetical protein 0.0566 0.2446 0.3548
Brugia malayi putative neuropeptide receptor NPR1 0.0566 0.2446 0.3548
Echinococcus granulosus alpha 1A adrenergic receptor 0.0566 0.2446 0.2152
Entamoeba histolytica tubulin family protein 0.0617 0.27 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0143 0.041
Schistosoma mansoni biogenic amine (5HT) receptor 0.0566 0.2446 0.4363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0566 0.2446 0.2152
Echinococcus multilocularis G protein coupled receptor 139 0.1166 0.5422 0.5244
Echinococcus multilocularis neuropeptides capa receptor 0.0566 0.2446 0.2152
Onchocerca volvulus 0.0566 0.2446 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0566 0.2446 0.2152
Brugia malayi larval opioid receptor 0.0566 0.2446 0.3548

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0.06 M-1 s-1 Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant KOH- was reported. ChEMBL. 6502594
k cat (ADMET) = 57 s-1 Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant (kcat) which is a first-order rate constant was determined ChEMBL. 6502594
Km (ADMET) = 3.5 mM Compound was tested for hydrolysis by acetylcholinesterase and the kinetic constant, (Km) an apparent dissociation constant, and related to the enzyme's affinity for the substrate was reported. ChEMBL. 6502594
Ratio (ADMET) = 160 Ratio of Kcat to Km was reported. ChEMBL. 6502594

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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