TDR Targets

Basic information

Technical information

TDR Targets ID: 645650
Name: N-[4-[(2-bromobenzoyl)amino]-2-methoxyphenyl] -1-benzofuran-2-carboxamide
MW: 465.296 | Formula: C23H17BrN2O4
H donors: 2 H acceptors: 2 LogP: 4.99 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1NC(=O)c1cc2c(o1)cccc2)NC(=O)c1ccccc1Br
InChi: 1S/C23H17BrN2O4/c1-29-20-13-15(25-22(27)16-7-3-4-8-17(16)24)10-11-18(20)26-23(28)21-12-14-6-2-5-9-19(14)30-21/h2-13H,1H3,(H,25,27)(H,26,28)
InChiKey: LIIINLOHQOVVIB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[(2-bromobenzoyl)amino]-2-methoxy-phenyl]benzofuran-2-carboxamide
N-[4-[[(2-bromophenyl)-oxomethyl]amino]-2-methoxyphenyl]-2-benzofurancarboxamide
N-[4-[(2-bromophenyl)carbonylamino]-2-methoxy-phenyl]-1-benzofuran-2-carboxamide
BIM-0021812.P001
Oprea1_765952
AN-465/14964401
STK069225
CBMicro_021965

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0579	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0063	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0158	0.0282
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.031	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.1377	0.1373
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0158	0.4515
Loa Loa (eye worm)	dihydrofolate reductase	0.0376	0.4464	1
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0013	0.0033	0.032
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0063	0.0069
Onchocerca volvulus		0.0058	0.0579	0.5683
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.031	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.029	0.0581
Schistosoma mansoni	cpg binding protein	0.0058	0.0579	0.0575
Onchocerca volvulus		0.0024	0.0158	0.1547
Echinococcus multilocularis	dihydrofolate reductase	0.0376	0.4464	0.4462
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0085	0.0117
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0033	0.012
Echinococcus multilocularis	dnaJ subfamily B	0.083	1	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0045	0.004
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.1859	0.1855
Echinococcus granulosus	cpg binding protein	0.0062	0.062	0.0616
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.031	1
Brugia malayi	Dihydrofolate reductase	0.0376	0.4464	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.031	0.1741
Schistosoma mansoni	dihydrofolate reductase	0.0376	0.4464	0.4462
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0063	0.0069
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0173	0.0574
Toxoplasma gondii	hypothetical protein	0.0264	0.3093	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0163	0.1859	0.4121
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0158	0.0786
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0045	0.004
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0173	0.0881
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0158	0.0167
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.031	0.1741
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.061	0.0606
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0173	0.0881
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.061	0.0606
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.061	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0264	0.3093	0.6906
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0088	0.0083
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0088	0.0125
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0158	0.0194
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0376	0.4464	1
Loa Loa (eye worm)	hypothetical protein	0.0264	0.3093	0.6906
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0085	0.0117
Schistosoma mansoni	microtubule-associated protein tau	0.07	0.8413	0.8413
Echinococcus granulosus	lysosomal alpha glucosidase	0.0163	0.1859	0.1855
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	0.1859	0.1855
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0063	0.0059
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.061	0.1497
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.031	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0063	0.0059
Brugia malayi	hypothetical protein	0.0016	0.0065	0.0073
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.031	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.031	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0158	0.0167
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.061	0.3625
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.031	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0264	0.3093	0.6906
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0376	0.4464	1
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0158	0.0167
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0485	0.1022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0158	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.029	0.0581
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0085	0.0119
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0144	0.1625	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.031	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0144	0.1625	1
Echinococcus granulosus	microtubule associated protein 2	0.07	0.8413	0.8413
Schistosoma mansoni	cpg binding protein	0.0062	0.062	0.0616
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.061	0.12
Loa Loa (eye worm)	hypothetical protein	0.0264	0.3093	0.6906
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0158	0.0194
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0579	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0085	0.0117
Brugia malayi	hypothetical protein	0.0025	0.0173	0.0317
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.061	0.12
Echinococcus granulosus	GPCR family 2	0.0016	0.0063	0.0059
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0033	0.012
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0013	0.0033	0.012
Schistosoma mansoni	alpha-glucosidase	0.014	0.1582	0.1578
Echinococcus multilocularis	microtubule associated protein 2	0.07	0.8413	0.8413
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.031	0.0626
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0033	0.012
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0063	0.0059
Onchocerca volvulus		0.0094	0.102	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0158	0.4515
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0144	0.1625	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.061	0.0606
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0059
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.031	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.031	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0376	0.4464	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.031	0.0469
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0158	0.0786
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0485	0.1022
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0158	0.4515
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.031	0.0305
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0063	0.0059
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0085	0.0027
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.031	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0485	0.1022
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0173	0.0574
Schistosoma mansoni	alpha glucosidase	0.0036	0.031	0.0305
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0158	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0158	0.0282
Echinococcus multilocularis	cpg binding protein	0.0062	0.062	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0085	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0485	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0158	0.0282
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0045	0.004
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.031	0.0305
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0158	0.0167
Schistosoma mansoni	alpha-glucosidase	0.014	0.1582	0.1578
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0045	0.004
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0158	0.0786
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0059
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0163	0.1859	0.4121
Brugia malayi	dihydrofolate reductase family protein	0.0376	0.4464	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0033	0.012
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0059
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.031	0.0626
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.0033	0.012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.061	0.12
Trypanosoma brucei	glucosidase, putative	0.0036	0.031	0.1741
Chlamydia trachomatis	dihydrofolate reductase	0.0376	0.4464	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0144	0.1625	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0317
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0063	0.0059
Schistosoma mansoni	hypothetical protein	0.0035	0.029	0.0285
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0045	0.004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0085	0.0117
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0173	0.0881
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0144	0.1625	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0013	0.0033	0.012
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0158	0.0167
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0158	0.0282
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0059
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.061	0.0606
Leishmania major	hypothetical protein, conserved	0.0025	0.0173	0.0881
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0063	0.0069
Toxoplasma gondii	histone lysine methyltransferase SET1	0.011	0.1216	0.3571
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0158	0.0282
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0158	0.0167
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0173	0.0574
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0088	0.0083
Trichomonas vaginalis	alpha-glucosidase, putative	0.0013	0.0033	0.012
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0158	0.0282
Schistosoma mansoni	hypothetical protein	0.083	1	1
Echinococcus granulosus	dihydrofolate reductase	0.0376	0.4464	0.4462
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.031	0.1741
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0144	0.1625	0.4974
Schistosoma mansoni	cpg binding protein	0.0062	0.062	0.0616

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 645650