Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1379 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.078 | 0.4388 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0179 | 0.1063 | 1 |
Onchocerca volvulus | 0.0095 | 0.0435 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.1993 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0999 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.095 | 0.951 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1379 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0117 | 0.0587 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0179 | 0.1063 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0047 | 0.0237 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.095 | 0.951 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0179 | 0.1063 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1379 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0094 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.078 | 0.4388 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0999 | 0.5619 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1379 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1379 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0304 | 0.1993 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1379 | 1 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0275 | 0.1778 | 0.0943 |
Loa Loa (eye worm) | glutaminase | 0.0275 | 0.1778 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0304 | 0.1993 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.095 | 0.5344 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0047 | 0.0237 |
Loa Loa (eye worm) | glutaminase 2 | 0.0275 | 0.1778 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.0999 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1379 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0275 | 0.1778 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.08 | 0.4016 |
Trichomonas vaginalis | glutaminase, putative | 0.0275 | 0.1778 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0999 | 0.5619 |
Schistosoma mansoni | glutaminase | 0.0275 | 0.1778 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.08 | 0.4016 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.08 | 0.4016 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0043 | 0.0047 | 0.0237 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0179 | 0.1063 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.095 | 0.5344 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.1993 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.095 | 0.951 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0047 | 0.0237 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0179 | 0.1063 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.