Detailed information for compound 652477

Basic information

Technical information
  • TDR Targets ID: 652477
  • Name: 3-(4-methylphenyl)-5-[(4-methylphenyl)amino]- 1,3-thiazolidine-2,4-dione
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC1SC(=O)N(C1=O)c1ccc(cc1)C
  • InChi: 1S/C17H16N2O2S/c1-11-3-7-13(8-4-11)18-15-16(20)19(17(21)22-15)14-9-5-12(2)6-10-14/h3-10,15,18H,1-2H3
  • InChiKey: HKSDAVZYGBEOEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-methylphenyl)-5-[(4-methylphenyl)amino]thiazolidine-2,4-dione
  • 3-(4-methylphenyl)-5-[(4-methylphenyl)amino]thiazolidine-2,4-quinone
  • IFLab1_004472
  • 3-p-Tolyl-5-p-tolylamino-thiazolidine-2,4-dione
  • BAS 00458465
  • IDI1_010227
  • Oprea1_245823
  • ST5230440
  • Oprea1_405784
  • EU-0034542

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0035 0.0568 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Trypanosoma brucei lipase, putative 0.0009 0.0023 0.0024
Giardia lamblia Hypothetical protein 0.0009 0.0023 0.0372
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.4259 0.4418
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.9357 0.9706
Leishmania major hypothetical protein, unknown function 0.0009 0.0023 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0703 0.0729
Leishmania major lipase, putative;with=GeneDB:LinJ31_V3.0860 0.0009 0.0023 0.0024
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0475 0.964 1
Leishmania major class 3 lipase, putative 0.0009 0.0023 0.0024
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Brugia malayi Pre-SET motif family protein 0.0031 0.0471 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0568 0.0812
Trypanosoma brucei Triglyceride lipase, putative 0.0009 0.0023 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0471 0.6709
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0023 0.0024
Leishmania major hypothetical protein, conserved 0.0009 0.0023 0.0024
Onchocerca volvulus 0.0009 0.0023 0.0024
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0622 0.9863
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0622 0.0645
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0703 1
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0023 0.0024
Trypanosoma brucei lipase domain protein, putative 0.0475 0.964 1
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Loa Loa (eye worm) lipase 0.0009 0.0023 0.0024
Onchocerca volvulus 0.0244 0.487 0.5051
Trypanosoma cruzi hypothetical protein, conserved 0.0475 0.964 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.063 1
Trichomonas vaginalis lipase containing protein, putative 0.0009 0.0023 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1183 0.1227
Trypanosoma cruzi lipase domain protein, putative 0.0009 0.0023 0.0024
Onchocerca volvulus 0.0475 0.964 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0622 0.0645
Leishmania major hypothetical protein, unknown function 0.0009 0.0023 0.0024
Onchocerca volvulus 0.0009 0.0023 0.0024
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.063 1
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0009 0.0023 0.0024
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0622 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0448 0.0465
Echinococcus granulosus tar DNA binding protein 0.0065 0.1183 0.1227
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0471 0.0489
Echinococcus multilocularis geminin 0.0347 0.6992 0.7253
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.9357 0.9706
Entamoeba histolytica hypothetical protein 0.0035 0.0568 0.9003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.054 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0703 1
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Trypanosoma cruzi lipase domain protein, putative 0.0009 0.0023 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1183 0.1227
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.278 0.3976
Brugia malayi Pre-SET motif family protein 0.0214 0.4259 0.4418
Trichomonas vaginalis set domain proteins, putative 0.0244 0.487 0.5051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0471 0.0674
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Brugia malayi Lipase family protein 0.0009 0.0023 0.0024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0622 0.0622
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.0485 0.9837 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Loa Loa (eye worm) lipase 0.0475 0.964 1
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0023 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1183 0.1692
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0622 0.0645
Trypanosoma brucei Triglyceride lipase, putative 0.0009 0.0023 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0475 0.964 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Plasmodium vivax SET domain protein, putative 0.0031 0.0471 0.6709
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Leishmania major lipase precursor-like protein 0.0009 0.0023 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0622 0.0645
Brugia malayi Lipase family protein 0.0009 0.0023 0.0024
Trypanosoma brucei Lipase (class 3), putative 0.0009 0.0023 0.0024
Plasmodium falciparum lipase, putative 0.0009 0.0023 0.0372
Brugia malayi Inositol-1 0.0038 0.0622 0.0645
Trypanosoma brucei lipase domain protein, putative 0.0009 0.0023 0.0024
Toxoplasma gondii lipase 0.0009 0.0023 0.0334
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.063 1
Schistosoma mansoni hypothetical protein 0.0347 0.6992 1
Loa Loa (eye worm) acetyltransferase 0.0143 0.278 0.2884
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0471 0.0489
Onchocerca volvulus 0.0031 0.0471 0.0489
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0622 0.0645
Toxoplasma gondii lipase 0.0009 0.0023 0.0334
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0471 0.0489
Leishmania major hypothetical protein, conserved 0.0009 0.0023 0.0024
Entamoeba histolytica lipase, putative 0.0009 0.0023 0.0372
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1183 0.1227
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0023 0.0334
Toxoplasma gondii lipase 0.0009 0.0023 0.0334
Schistosoma mansoni hypothetical protein 0.0347 0.6992 1
Trichomonas vaginalis lipase containing protein, putative 0.0475 0.964 1
Trichomonas vaginalis lipase containing protein, putative 0.0475 0.964 1
Giardia lamblia Hypothetical protein 0.0009 0.0023 0.0372
Schistosoma mansoni lipase 0.0009 0.0023 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0622 0.0645
Entamoeba histolytica lipase, putative 0.0009 0.0023 0.0372
Trypanosoma brucei lipase-like protein, putative 0.0009 0.0023 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1183 0.1692
Giardia lamblia hypothetical protein 0.0009 0.0023 0.0372
Trypanosoma cruzi Triglyceride lipase, putative 0.0009 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0703 1
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1183 0.1692
Brugia malayi Lipase family protein 0.0475 0.964 1
Trypanosoma cruzi Lipase (class 3), putative 0.0009 0.0023 0.0024
Entamoeba histolytica lipase, putative 0.0009 0.0023 0.0372
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.278 0.2884
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0471 0.0674
Brugia malayi TAR-binding protein 0.0065 0.1183 0.1227
Loa Loa (eye worm) hypothetical protein 0.0031 0.0471 0.0489
Brugia malayi Lipase family protein 0.0009 0.0023 0.0024
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1183 0.1692
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Entamoeba histolytica lipase, putative 0.0009 0.0023 0.0372
Entamoeba histolytica hypothetical protein 0.0035 0.0568 0.9003
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0622 0.0645
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0622 0.0645
Echinococcus granulosus neuropeptide s receptor 0.0461 0.9357 0.9706
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0568 0.0589
Trypanosoma brucei triacylglycerol lipase, putative 0.0009 0.0023 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0471 0.0674
Entamoeba histolytica hypothetical protein 0.0035 0.0568 0.9003
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.278 0.2884
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0703 0.0729
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.054 0.0549
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1183 0.1227
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1183 0.1692
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0703 0.0729
Toxoplasma gondii lipase 0.0009 0.0023 0.0334
Trypanosoma brucei lipase domain protein, putative 0.0475 0.964 1
Giardia lamblia hypothetical protein 0.0009 0.0023 0.0372
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0372
Schistosoma mansoni inositol monophosphatase 0.0038 0.0622 0.0889
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0475 0.964 1
Onchocerca volvulus 0.0009 0.0023 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0622 0.0645
Leishmania major hypothetical protein, conserved 0.0475 0.964 1
Loa Loa (eye worm) inositol-1 0.0038 0.0622 0.0645
Giardia lamblia Hypothetical protein 0.0009 0.0023 0.0372
Brugia malayi RNA binding protein 0.0065 0.1183 0.1227
Brugia malayi Lipase family protein 0.0009 0.0023 0.0024
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Leishmania major lipase, putative 0.0009 0.0023 0.0024
Leishmania major lipase domain protein, putative 0.0009 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0568 0.9003
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Loa Loa (eye worm) lipase 0.0009 0.0023 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0024
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0009 0.0023 0.0024
Trypanosoma cruzi lipase, putative 0.0009 0.0023 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0568 0.0589
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.2698 0.2798
Trypanosoma cruzi lipase-like protein, putative 0.0009 0.0023 0.0024
Echinococcus granulosus geminin 0.0347 0.6992 0.7253
Brugia malayi hypothetical protein 0.0035 0.0568 0.0589
Schistosoma mansoni inositol monophosphatase 0.0038 0.0622 0.0889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0471 0.0674
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.9357 0.9706
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0622 0.8851
Loa Loa (eye worm) RNA binding protein 0.0065 0.1183 0.1227
Leishmania major hypothetical protein, conserved 0.0009 0.0023 0.0024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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