Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0061 | 0.2342 | 0.2342 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0012 | 0.0081 | 0.0081 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1566 | 0.1566 |
Brugia malayi | Cation transporter family protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0012 | 0.0081 | 0.0081 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0059 | 0.2259 | 0.2259 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.4866 | 0.4866 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.012 | 0.5085 | 0.5085 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1566 | 0.1566 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1566 | 0.1566 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0012 | 0.0081 | 0.0081 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0023 | 0.0564 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0081 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | ACC-1 protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Echinococcus granulosus | nAChR subunit | 0.0012 | 0.0081 | 0.0081 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0023 | 0.0564 | 1 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | 0.0012 | 0.0081 | 0.1438 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5085 | 0.5085 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0012 | 0.0081 | 0.0081 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0012 | 0.0081 | 0.0081 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1566 | 0.1566 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1566 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | nAChR subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1566 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1566 | 0.1566 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.4866 | 0.4866 |
Echinococcus multilocularis | nAChR subunit | 0.0012 | 0.0081 | 0.0081 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0081 | 0.0081 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1566 | 0.1566 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0012 | 0.0081 | 0.0081 |
Onchocerca volvulus | 0.0012 | 0.0081 | 0.1438 | |
Brugia malayi | Cation transporter family protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | LGC-31 protein | 0.0023 | 0.0564 | 0.0564 |
Onchocerca volvulus | Putative nachr subunit | 0.0023 | 0.0564 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1566 | 0.1566 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.4866 | 0.4866 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0012 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0012 | 0.0081 | 0.0081 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.012 | 0.5085 | 0.5085 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0.0564 | 0.0564 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | ACC-1 protein | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Cation transporter family protein | 0.0023 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0023 | 0.0564 | 0.0564 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0023 | 0.0564 | 0.0564 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.012 | 0.5085 | 0.5085 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0564 | 0.0564 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HD50 (functional) | = 34.6 uM kg-1 | Hypnotic dose was determined by observing loss of righting reflex for a minimum period of 30 sec in 50% of treated mice after i.v. administration. | ChEMBL. | 9171876 |
IC50 (binding) | = 2561 nM | The concentration of the compound required to inhibit 50% of binding of [35S]-TBPS to Gamma-aminobutyric-acid A receptor to rat whole brain membranes. | ChEMBL. | 9171876 |
TI (ADMET) | = 4.6 | Therapeutic index of the compound was determined by the ratio between LD50 to HD50 | ChEMBL. | 9171876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.