TDR Targets

Basic information

Technical information

TDR Targets ID: 655366
Name: 2-(3-methylphenyl)-N-(4-methylphenyl)quinazol in-4-amine
MW: 325.406 | Formula: C22H19N3
H donors: 1 H acceptors: 2 LogP: 5.81 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)Nc1nc(nc2c1cccc2)c1cccc(c1)C
InChi: 1S/C22H19N3/c1-15-10-12-18(13-11-15)23-22-19-8-3-4-9-20(19)24-21(25-22)17-7-5-6-16(2)14-17/h3-14H,1-2H3,(H,23,24,25)
InChiKey: ZOMMKHLWMDGILB-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(3-methylphenyl)-N-(4-methylphenyl)-4-quinazolinamine
(4-methylphenyl)-[2-(3-methylphenyl)quinazolin-4-yl]amine
Oprea1_560025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	smad	0.0128	0.0389	0.0886
Loa Loa (eye worm)	nuclear factor I	0.0071	0.0075	0.0075
Echinococcus granulosus	peptidase Clp S14 family	0.0168	0.0608	0.3265
Brugia malayi	N-terminal motif family protein	0.0482	0.2334	0.2334
Plasmodium vivax	ataxin-2 like protein, putative	0.0295	0.1304	1
Loa Loa (eye worm)	hypothetical protein	0.1252	0.6563	0.6563
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.04	0.1883	1
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1298	0.6814	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0295	0.1304	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.023	0.0949	0.5097
Brugia malayi	isocitrate dehydrogenase	0.023	0.0949	0.0949
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0898	0.4617	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0396	0.1862	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1298	0.6814	1
Brugia malayi	Isocitrate dehydrogenase	0.023	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2334	0.2334
Schistosoma mansoni	hypothetical protein	0.0396	0.1862	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0396	0.1862	0.1862
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.023	0.0949	0.687
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0256	0.1093	0.8138
Brugia malayi	MH1 domain containing protein	0.0128	0.0389	0.0389
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0256	0.1093	0.8138
Toxoplasma gondii	isocitrate dehydrogenase	0.023	0.0949	0.687
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1298	0.6814	1
Schistosoma mansoni	hypothetical protein	0.0396	0.1862	0.4244
Trypanosoma brucei	PAB1-binding protein , putative	0.0295	0.1304	0.3796
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1252	0.6563	0.6563
Schistosoma mansoni	smad1 5 8 and	0.0128	0.0389	0.0886
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1298	0.6814	0.6814
Schistosoma mansoni	smad1 5 8 and	0.0128	0.0389	0.0886
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0128	0.0389	0.0886
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0256	0.1093	0.5869
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1298	0.6814	0.6814
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1298	0.6814	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.1878	1	1
Schistosoma mansoni	hypothetical protein	0.0396	0.1862	0.4244
Schistosoma mansoni	smad1 5 8 and	0.0128	0.0389	0.0886
Echinococcus granulosus	smad	0.0128	0.0389	0.2087
Loa Loa (eye worm)	hypothetical protein	0.011	0.0291	0.0291
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0246	0.1039	0.1436
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.0251	0.1062	0.242
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1062	0.1062
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0132	0.0411	0.221
Echinococcus multilocularis	GPCR, family 2	0.0396	0.1862	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.023	0.0949	0.5097
Leishmania major	hypothetical protein, conserved	0.04	0.1883	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0128	0.0389	0.0389
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0128	0.0389	0.2087
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0396	0.1862	0.1862
Schistosoma mansoni	hypothetical protein	0.0856	0.4387	1
Loa Loa (eye worm)	hypothetical protein	0.0856	0.4387	0.4387
Brugia malayi	Latrophilin receptor protein 2	0.0396	0.1862	0.1862
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0256	0.1093	0.8138
Loa Loa (eye worm)	transcription factor SMAD2	0.1878	1	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0256	0.1093	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.1304	0.1304
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1252	0.6563	0.6563
Trypanosoma cruzi	PAB1-binding protein , putative	0.0295	0.1304	0.3796
Brugia malayi	latrophilin 2 splice variant baaae	0.0856	0.4387	0.4387
Brugia malayi	Probable ClpP-like protease	0.0256	0.1093	0.1093
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0256	0.1093	0.8138
Loa Loa (eye worm)	hypothetical protein	0.0256	0.1093	0.1093
Schistosoma mansoni	peptidase Clp (S14 family)	0.0256	0.1093	0.2491
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0256	0.1093	0.5869
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0256	0.1093	1
Onchocerca volvulus		0.011	0.0291	0.0427
Onchocerca volvulus		0.1298	0.6814	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0295	0.1304	0.1304
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.0251	0.1062	0.242
Leishmania major	hypothetical protein, conserved	0.0295	0.1304	0.3796
Brugia malayi	MH2 domain containing protein	0.0128	0.0389	0.0389
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0396	0.1862	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.023	0.0949	0.5097
Trypanosoma cruzi	PAB1-binding protein , putative	0.0295	0.1304	0.3796
Brugia malayi	Smad1	0.0128	0.0389	0.0389
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1298	0.6814	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.1252	0.6563	0.6563
Schistosoma mansoni	hypothetical protein	0.0132	0.0411	0.0938
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.023	0.0949	0.085
Echinococcus multilocularis	Smad4	0.0128	0.0389	0.2087
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.023	0.0949	0.5097
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0396	0.1862	1
Loa Loa (eye worm)	pip kinase 2	0.0251	0.1062	0.1062
Brugia malayi	Pip kinase protein 2	0.0251	0.1062	0.1062
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0128	0.0389	0.2087
Echinococcus multilocularis	phosphatidylinositol 5 phosphate 4 kinase type 2	0.0251	0.1062	0.5703
Echinococcus granulosus	GPCR family 2	0.0396	0.1862	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.023	0.0949	0.5097
Trypanosoma cruzi	hypothetical protein, conserved	0.04	0.1883	1
Brugia malayi	MH1 domain containing protein	0.0128	0.0389	0.0389
Plasmodium falciparum	ataxin-2 like protein, putative	0.0295	0.1304	1
Loa Loa (eye worm)	Smad1	0.0128	0.0389	0.0389
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1298	0.6814	1
Onchocerca volvulus		0.0251	0.1062	0.1558
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0256	0.1093	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0256	0.1093	0.5
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.023	0.0949	0.2163
Brugia malayi	hypothetical protein	0.019	0.073	0.073
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1298	0.6814	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.023	0.0949	0.0949
Brugia malayi	MH1 domain containing protein	0.0071	0.0075	0.0075
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0132	0.0411	0.221
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0168	0.0608	0.3265
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1298	0.6814	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0482	0.2334	0.3426
Echinococcus granulosus	mothers against decapentaplegic 5	0.0128	0.0389	0.2087
Schistosoma mansoni	hypothetical protein	0.0396	0.1862	0.4244
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0256	0.1093	1
Echinococcus granulosus	phosphatidylinositol 5 phosphate 4 kinase type 2	0.0251	0.1062	0.5703
Brugia malayi	MH2 domain containing protein	0.0128	0.0389	0.0389
Trypanosoma cruzi	hypothetical protein, conserved	0.04	0.1883	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.023	0.0949	0.5097
Toxoplasma gondii	isocitrate dehydrogenase	0.023	0.0949	0.687
Plasmodium falciparum	ataxin-2 like protein, putative	0.0295	0.1304	1
Brugia malayi	hypothetical protein	0.011	0.0291	0.0291
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0396	0.1862	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0128	0.0389	0.2087
Schistosoma mansoni	Smad4	0.0128	0.0389	0.0886
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1298	0.6814	1
Echinococcus multilocularis	smad	0.0128	0.0389	0.2087
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.0389	0.0389
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0396	0.1862	0.1862
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0168	0.0608	0.4744
Brugia malayi	MH1 domain containing protein	0.0071	0.0075	0.0075
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1298	0.6814	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.023	0.0949	0.687
Echinococcus granulosus	Smad4	0.0128	0.0389	0.2087

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 655366