Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0064 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0095 | 0.0199 | 1 |
Trypanosoma cruzi | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0095 | 0.0199 | 0.0199 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.3884 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase (hydroxylase) | 0.0095 | 0.0199 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0199 | 1 |
Mycobacterium tuberculosis | Monooxygenase EthA | 0.0095 | 0.0199 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0095 | 0.0199 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0095 | 0.0199 | 1 |
Mycobacterium tuberculosis | Possible alanine rich dehydrogenase | 0.0095 | 0.0199 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0064 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0055 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.3884 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0095 | 0.0199 | 1 |
Onchocerca volvulus | 0.0095 | 0.0199 | 0.5 | |
Plasmodium vivax | adrenodoxin reductase, putative | 0.0095 | 0.0199 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0095 | 0.0199 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0095 | 0.0199 | 0.6174 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0199 | 0.5976 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Leishmania major | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0095 | 0.0199 | 0.0199 |
Trypanosoma cruzi | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0095 | 0.0199 | 0.0199 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0095 | 0.0199 | 0.0199 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0147 | 0.0332 | 1 |
Mycobacterium leprae | Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0095 | 0.0199 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0055 | 0.2756 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.0199 | 0.5976 |
Mycobacterium ulcerans | dehydrogenase | 0.0095 | 0.0199 | 1 |
Mycobacterium tuberculosis | UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0095 | 0.0199 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0064 | 0.1991 |
Plasmodium vivax | unspecified product | 0.0095 | 0.0199 | 1 |
Loa Loa (eye worm) | lethal protein 721 | 0.0095 | 0.0199 | 0.5976 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0095 | 0.0199 | 1 |
Plasmodium vivax | unspecified product | 0.0095 | 0.0199 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.3884 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.0322 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0064 | 0.3225 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0147 | 0.0332 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0147 | 0.0332 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0055 | 1 |
Brugia malayi | all-trans-13,14-dihydroretinol saturase | 0.0095 | 0.0199 | 0.5976 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0095 | 0.0199 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0064 | 0.3225 |
Mycobacterium leprae | Probable monooxygenase EthA | 0.0095 | 0.0199 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0095 | 0.0199 | 1 |
Mycobacterium ulcerans | UDP-galactopyranose mutase Glf | 0.0095 | 0.0199 | 1 |
Plasmodium vivax | unspecified product | 0.0095 | 0.0199 | 1 |
Toxoplasma gondii | electron transfer flavoprotein-ubiquinone oxidoreductase | 0.0095 | 0.0199 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0095 | 0.0199 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0095 | 0.0199 | 1 |
Schistosoma mansoni | amine oxidase | 0.0095 | 0.0199 | 0.5976 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0147 | 0.0332 | 1 |
Echinococcus multilocularis | prenylcysteine oxidase | 0.0095 | 0.0199 | 0.5976 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0199 | 0.5976 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0064 | 0.3225 |
Mycobacterium tuberculosis | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase) | 0.0095 | 0.0199 | 1 |
Mycobacterium ulcerans | monooxygenase EthA | 0.0095 | 0.0199 | 1 |
Echinococcus granulosus | prenylcysteine oxidase | 0.0095 | 0.0199 | 0.6174 |
Mycobacterium ulcerans | dehydrogenase | 0.0095 | 0.0199 | 1 |
Toxoplasma gondii | prenylcysteine oxidase | 0.0095 | 0.0199 | 1 |
Onchocerca volvulus | 0.0095 | 0.0199 | 0.5 | |
Mycobacterium tuberculosis | Unknown protein | 0.0095 | 0.0199 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.