TDR Targets

Basic information

Technical information

TDR Targets ID: 657610
Name: ethyl 2-amino-4-(2-methylphenyl)-5-oxo-7-phen yl-4,6,7,8-tetrahydrochromene-3-carboxylate
MW: 403.47 | Formula: C25H25NO4
H donors: 1 H acceptors: 2 LogP: 4.25 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(N)OC2=C(C1c1ccccc1C)C(=O)CC(C2)c1ccccc1
InChi: 1S/C25H25NO4/c1-3-29-25(28)23-21(18-12-8-7-9-15(18)2)22-19(27)13-17(14-20(22)30-24(23)26)16-10-5-4-6-11-16/h4-12,17,21H,3,13-14,26H2,1-2H3
InChiKey: QVCGRBDMSATYLE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-4-(2-methylphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
2-amino-5-keto-4-(2-methylphenyl)-7-phenyl-4,6,7,8-tetrahydrochromene-3-carboxylic acid ethyl ester
AN-919/15232459
ChemDiv1_007307
EU-0074861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0097	0.1389	0.3898
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0199	0.3564	1
Schistosoma mansoni	single-minded	0.0148	0.2486	0.4021
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0042	0.02	0.5
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0042	0.02	0.0562
Schistosoma mansoni	jun-related protein	0.0317	0.6119	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0039	0.0125	0.035
Echinococcus granulosus	thymidylate synthase	0.0069	0.0783	0.0967
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0391	0.7692	1
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0042	0.02	0.253
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0042	0.02	0.0562
Onchocerca volvulus		0.0069	0.0783	0.1265
Plasmodium falciparum	GAF domain-related protein, putative	0.0063	0.0655	0.4015
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0205	0.3699	0.3697
Onchocerca volvulus		0.0307	0.5889	1
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0655	0.1838
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0135	0.2204	0.6184
Trypanosoma brucei	acetyl-CoA carboxylase	0.011	0.1671	0.4688
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0125	0.035
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0039	0.0125	0.035
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0042	0.02	0.0259
Echinococcus granulosus	jun protein	0.0391	0.7692	1
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0042	0.02	0.0562
Echinococcus multilocularis	transfer RNA-Lys	0.011	0.1657	0.211
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0039	0.0125	0.035
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0063	0.0655	0.8365
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0069	0.0783	1
Trichomonas vaginalis	guanylate cyclase, putative	0.0039	0.0125	0.035
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0039	0.0125	0.035
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0199	0.3564	1
Plasmodium falciparum	hexose transporter	0.0106	0.1568	1
Brugia malayi	hypothetical protein	0.0035	0.0043	0.004
Brugia malayi	hypothetical protein	0.0307	0.5889	0.5888
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0088	0.118	0.1871
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Schistosoma mansoni	glucose transport protein	0.0106	0.1568	0.2509
Chlamydia trachomatis	biotin carboxylase	0.0038	0.0117	0.9064
Toxoplasma gondii	hypothetical protein	0.0063	0.0655	0.2043
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0097	0.1389	0.8829
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.011	0.1671	0.2128
Echinococcus granulosus	aryl hydrocarbon receptor	0.0039	0.0125	0.0107
Schistosoma mansoni	aryl hydrocarbon receptor	0.0148	0.2486	0.4021
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0003	0.0008
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0042	0.02	0.0206
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0039	0.0125	0.035
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0097	0.1389	0.3898
Schistosoma mansoni	acetyl-CoA carboxylase	0.011	0.1671	0.2679
Brugia malayi	hypoxia-induced factor 1	0.0459	0.9171	0.9171
Schistosoma mansoni	sodium/chloride dependent transporter	0.0205	0.3699	0.6017
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0039	0.0125	0.035
Brugia malayi	Carboxyl transferase domain containing protein	0.0107	0.1588	0.1585
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0039	0.0125	0.0082
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0205	0.3699	0.3672
Schistosoma mansoni	glucose transport protein	0.0106	0.1568	0.2509
Toxoplasma gondii	pyruvate carboxylase	0.0042	0.02	0.0525
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.1568	0.5089
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.0655	0.8063
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0088	0.118	0.1177
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0039	0.0125	0.0107
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0063	0.0655	0.3123
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Brugia malayi	hypothetical protein	0.0167	0.2888	0.2886
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0199	0.3564	0.4602
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.011	0.1671	0.2128
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Brugia malayi	thymidylate synthase	0.0069	0.0783	0.078
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0125	0.035
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.011	0.1671	0.5433
Schistosoma mansoni	hypothetical protein	0.0106	0.1568	0.2509
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0039	0.0125	0.035
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0068	0.0766	0.2149
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0039	0.0125	0.0107
Echinococcus granulosus	single minded 2	0.011	0.1657	0.211
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.008	0.1014	0.6372
Brugia malayi	sulfakinin receptor protein	0.0167	0.2888	0.2886
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0039	0.0125	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Onchocerca volvulus		0.0205	0.3699	0.6254
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0069	0.0783	1
Brugia malayi	Cytochrome P450 family protein	0.0042	0.019	0.0187
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0042	0.02	0.0562
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0039	0.0125	0.035
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0063	0.0655	0.8365
Loa Loa (eye worm)	hypothetical protein	0.0167	0.2888	0.2858
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3699	0.3672
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0039	0.0125	0.035
Onchocerca volvulus		0.0039	0.0125	0.014
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Treponema pallidum	sodium- and chloride- dependent transporter	0.0205	0.3699	0.5
Loa Loa (eye worm)	sugar transporter	0.0106	0.1568	0.1531
Loa Loa (eye worm)	norepinephrine transporter	0.0205	0.3699	0.3672
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0199	0.3564	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0097	0.1389	0.4493
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0088	0.118	0.1486
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0069	0.0783	0.1217
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0088	0.118	0.3311
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.118	0.1142
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0125	0.035
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0125	0.0082
Toxoplasma gondii	hypothetical protein	0.0174	0.3039	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0097	0.1389	0.8829
Echinococcus granulosus	serotonin transporter	0.0205	0.3699	0.478
Echinococcus multilocularis	jun protein	0.0391	0.7692	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0135	0.2204	0.6184
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3039	0.8528
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Leishmania major	carboxylase, putative	0.0042	0.02	0.0562
Mycobacterium ulcerans	putative regulatory protein	0.0063	0.0655	0.3123
Brugia malayi	Sugar transporter family protein	0.0106	0.1568	0.1565
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.1568	0.1993
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3699	0.3672
Trichomonas vaginalis	conserved hypothetical protein	0.0199	0.3564	1
Leishmania major	protein kinase, putative	0.0039	0.0125	0.035
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0042	0.02	0.1148
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0042	0.02	0.0259
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0039	0.0125	0.0107
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0199	0.3564	0.4602
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0039	0.0125	0.035
Schistosoma mansoni	hypothetical protein	0.0317	0.6119	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.038	0.7462	0.7451
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0459	0.9171	0.9167
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0043	0.004
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0199	0.3564	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0088	0.118	0.3311
Echinococcus multilocularis	thymidylate synthase	0.0069	0.0783	0.0967
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3039	0.8528
Echinococcus multilocularis	serotonin transporter	0.0205	0.3699	0.478
Brugia malayi	bZIP transcription factor family protein	0.0391	0.7692	0.7692
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0042	0.02	0.253
Leishmania major	acetyl-CoA carboxylase, putative	0.011	0.1671	0.4688
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3039	0.8528
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0097	0.1389	0.3898
Toxoplasma gondii	GAF domain-containing protein	0.0063	0.0655	0.2043
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0039	0.0125	0.035
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0042	0.02	0.0562
Mycobacterium ulcerans	putative regulatory protein	0.0063	0.0655	0.3123
Mycobacterium ulcerans	thymidylate synthase	0.0069	0.0783	0.3998
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0135	0.2204	0.6184
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0042	0.02	0.0206
Loa Loa (eye worm)	serotonin transporter b	0.0205	0.3699	0.3672
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.1568	0.4399
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0199	0.3564	1
Brugia malayi	PAS domain containing protein	0.0148	0.2486	0.2484
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Schistosoma mansoni	pyruvate carboxylase	0.0042	0.02	0.0259
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0199	0.3564	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0199	0.3564	0.5794
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0205	0.3699	0.6017
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.008	0.1014	0.6372
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0035	0.0043	0.004
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0033	0.0003	0.0008
Mycobacterium ulcerans	putative regulatory protein	0.011	0.1657	1
Leishmania major	protein kinase, putative	0.0039	0.0125	0.035
Plasmodium vivax	hexose transporter	0.0106	0.1568	1
Schistosoma mansoni	glucose transport protein	0.0106	0.1568	0.2509
Trichomonas vaginalis	guanylate cyclase, putative	0.0039	0.0125	0.035
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0391	0.7692	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0042	0.019	0.0147
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0088	0.118	0.1486
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0199	0.3564	1
Echinococcus granulosus	General substrate transporter	0.0091	0.1248	0.1575
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0039	0.0125	0.035
Onchocerca volvulus		0.011	0.1657	0.2761
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0043	0.004
Trichomonas vaginalis	adenylate cyclase, putative	0.0039	0.0125	0.035
Loa Loa (eye worm)	thymidylate synthase	0.0069	0.0783	0.0743
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0035	0.0043	0.004
Loa Loa (eye worm)	hypothetical protein	0.0498	1	1
Echinococcus multilocularis	General substrate transporter	0.0091	0.1248	0.1575
Toxoplasma gondii	hypothetical protein	0.0063	0.0655	0.2043
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3699	0.3672
Brugia malayi	bHLH-PAS transcription factor	0.011	0.1657	0.1654
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.011	0.1671	0.5433
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0107	0.1588	0.1551
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1568	0.1993
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0655	0.0615
Plasmodium vivax	hypothetical protein, conserved	0.0063	0.0655	0.4015
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0088	0.118	0.3311
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0088	0.118	0.1177

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 657610