Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0092 | 0.353 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0638 | 0.0577 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.2366 | 0.6702 |
Schistosoma mansoni | neprilysin | 0.0024 | 0.0481 | 0.023 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0638 | 0.0638 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2366 | 0.6702 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2366 | 0.2366 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0046 | 0.1486 | 0.345 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0638 | 0.0638 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2366 | 0.6702 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0638 | 0.1808 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0235 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2366 | 0.6702 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1497 | 0.4242 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1448 | 0.1448 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2453 | 0.2453 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.2366 | 0.6702 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0046 | 0.1486 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2453 | 0.2453 |
Brugia malayi | peptidase family M13 containing protein | 0.0022 | 0.0409 | 0.0346 |
Echinococcus granulosus | lamin | 0.0027 | 0.0638 | 0.1808 |
Schistosoma mansoni | lamin | 0.0027 | 0.0638 | 0.0734 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1497 | 0.3486 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0092 | 0.353 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0068 | 0.2453 | 0.2453 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0046 | 0.1486 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0616 | 0.0616 |
Brugia malayi | Peptidase family M13 containing protein | 0.0092 | 0.353 | 0.3487 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0638 | 0.1808 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0638 | 0.1808 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0638 | 0.1808 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1497 | 0.1497 |
Toxoplasma gondii | peptidase family M13 protein | 0.0092 | 0.353 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.2366 | 0.627 |
Onchocerca volvulus | 0.0045 | 0.1448 | 1 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0024 | 0.0481 | 0.023 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0046 | 0.1486 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0046 | 0.1486 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2453 | 0.2453 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0092 | 0.353 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1497 | 0.1441 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0092 | 0.353 | 0.3487 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2366 | 0.2315 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0066 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0068 | 0.2453 | 0.2453 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1497 | 0.4242 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1497 | 0.4242 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0022 | 0.0409 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0638 | 0.0734 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2366 | 0.6702 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0092 | 0.353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2366 | 0.2366 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1497 | 0.3486 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.353 | 0.353 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.2366 | 0.2366 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1497 | 0.3486 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.2366 | 0.2366 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0638 | 0.1808 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1497 | 0.4242 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0092 | 0.353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2525 | 0.2525 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2366 | 0.2315 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.353 | 0.353 |
Schistosoma mansoni | lamin | 0.0027 | 0.0638 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.353 | 0.353 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0638 | 0.0577 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0092 | 0.353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0481 | 0.023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.