Detailed information for compound 664781

Basic information

Technical information
  • TDR Targets ID: 664781
  • Name: STK170066
  • MW: 459.356 | Formula: C21H19BrN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)C(=O)Nc1ccccc1Br)C
  • InChi: 1S/C21H19BrN2O3S/c1-15-7-13-18(14-8-15)28(26,27)24(2)17-11-9-16(10-12-17)21(25)23-20-6-4-3-5-19(20)22/h3-14H,1-2H3,(H,23,25)
  • InChiKey: HRGKQBYHDCWFRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01144970

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans sugar transporter 0.0015 0.0084 0.1758
Echinococcus granulosus General substrate transporter 0.0091 0.1821 0.5559
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0254
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0484 0.0456
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0484 0.0456
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0117 0.0353
Trypanosoma brucei glucose transporter 1E 0.0033 0.0493 0.8107
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0549 0.1601
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0825 0.2517
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0469 0.2167
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0117 0.1977
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0117 0.0411
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Onchocerca volvulus 0.0015 0.0084 0.174
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0084 0.0253
Plasmodium falciparum hexose transporter 0.0106 0.216 0.2137
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0825 0.2451
Entamoeba histolytica protein kinase, putative 0.0032 0.0484 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0084 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0117 0.0355
Brugia malayi PAS domain containing protein 0.0043 0.0733 0.2169
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0117 0.0052
Leishmania major protein kinase, putative 0.0032 0.0484 0.8212
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0283 0.395
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.228
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.119
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0283 0.0862
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0084 0.1406
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0084 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0169 0.3541
Onchocerca volvulus 0.0015 0.0084 0.174
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0484 0.0617
Onchocerca volvulus 0.0015 0.0084 0.174
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 1
Onchocerca volvulus 0.0015 0.0084 0.174
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0169 0.285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0589 0.0561
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0117 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Brugia malayi Sugar transporter family protein 0.0015 0.0084 0.0167
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0484 0.14
Schistosoma mansoni protein kinase 0.0032 0.0484 0.2132
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0084 0.0253
Onchocerca volvulus 0.0015 0.0084 0.174
Brugia malayi major facilitator superfamily protein 0.0015 0.0084 0.0167
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0484 0.1475
Brugia malayi Cam kinase protein 1 0.0032 0.0484 0.14
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Brugia malayi Cytochrome P450 family protein 0.0019 0.0169 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Onchocerca volvulus 0.0032 0.0476 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0484 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0484 0.0456
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.8373
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0253
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.119
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0469 0.9253
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0283 0.0782
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0026 0.0333 0.1014
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0117 0.0665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0117 0.0355
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0117 0.0088
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0084 0.0253
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0254
Mycobacterium ulcerans putative regulatory protein 0.0032 0.0476 1
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0084 0.0383
Brugia malayi hypothetical protein 0.0015 0.0084 0.0167
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0283 0.4801
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0253
Schistosoma mansoni hypothetical protein 0.0035 0.0549 0.2439
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0217 0.0999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0825 0.2517
Onchocerca volvulus 0.0015 0.0084 0.174
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0084 0.0383
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0117 0.0353
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0825 0.3732
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0155 0.3274 1
Toxoplasma gondii protein kinase, putative 0.03 0.6571 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0825 0.2517
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0087
Onchocerca volvulus 0.0015 0.0084 0.174
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0047 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Loa Loa (eye worm) hypothetical protein 0.0052 0.0922 0.2814
Echinococcus multilocularis GPCR, family 2 0.0016 0.0117 0.0353
Plasmodium vivax sugar transporter, putative 0.0015 0.0084 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0825 0.2517
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0035 0.0544 0.1659
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Echinococcus granulosus muscleblind protein 0.0155 0.3274 1
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0117 0.1977
Brugia malayi Sugar transporter family protein 0.0015 0.0084 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Brugia malayi bHLH-PAS transcription factor 0.0032 0.0476 0.1376
Brugia malayi Sugar transporter family protein 0.0106 0.216 0.6567
Onchocerca volvulus 0.0015 0.0084 0.174
Loa Loa (eye worm) hypothetical protein 0.0146 0.3063 0.9355
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0484 0.1475
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.003 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0035 0.0544 0.1659
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Loa Loa (eye worm) hypothetical protein 0.0035 0.0549 0.1675
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0283 1
Onchocerca volvulus 0.0015 0.0084 0.174
Schistosoma mansoni protein kinase 0.0032 0.0484 0.2132
Brugia malayi hypoxia-induced factor 1 0.0134 0.2806 0.8557
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0484 0.7919
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0117 0.0355
Loa Loa (eye worm) sugar transporter 0.0015 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0862
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0117 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0084 0.0383
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0283 0.1307
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0084 0.1758
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Brugia malayi hypothetical protein 0.0146 0.3063 0.9349
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.228
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus multilocularis RUN 0.0013 0.003 0.0087
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.003 0.0087
Brugia malayi Muscleblind-like protein 0.0155 0.3274 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0825 0.3732
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0253
Leishmania major cytochrome p450-like protein 0.0019 0.0169 0.285
Onchocerca volvulus 0.0015 0.0084 0.174
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Loa Loa (eye worm) hypothetical protein 0.0032 0.0484 0.1475
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0484 0.1475
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0253
Schistosoma mansoni glucose transporter 0.0015 0.0084 0.0254
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.003 0.0087
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0169 0.285
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Loa Loa (eye worm) sugar transporter 0.0106 0.216 0.6597
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0084 0.0383
Schistosoma mansoni glucose transport protein 0.0106 0.216 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0825 0.3732
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.595
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0484 0.2236
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.0167
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0087
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.8373
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0047 0.0786
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0117 0.0268
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0084 0.1758
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0169 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0484 0.2132
Echinococcus granulosus Polycystic kidney disease protein 0.0013 0.003 0.0087
Schistosoma mansoni lipoxygenase 0.0035 0.0544 0.2414
Schistosoma mansoni glucose transport protein 0.0106 0.216 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0484 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.228
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.2061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.1429
Schistosoma mansoni protein kinase 0.0032 0.0484 0.2132
Onchocerca volvulus 0.0015 0.0084 0.174
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0408
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0253
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0047 0.0786
Onchocerca volvulus Putative transporter 0.0015 0.0084 0.174
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0084 0.0054
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3274 1
Onchocerca volvulus 0.0013 0.003 0.0603
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.1429
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0484 0.0456
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0169 0.0512
Plasmodium vivax CDK-related protein kinase 6, putative 0.045 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0408
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.216 0.3201
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Echinococcus multilocularis muscleblind protein 0.0155 0.3274 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0117 0.0088
Schistosoma mansoni hypothetical protein 0.0106 0.216 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0589 1
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0589 0.0561
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0084 0.0254
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0047 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.228
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.228
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0084 0.0383
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0283 0.0308
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0084 0.1406
Loa Loa (eye worm) hypoxia-induced factor 1 0.0134 0.2806 0.857
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0084 0.1406
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0253
Brugia malayi Cytochrome P450 family protein 0.0019 0.0169 0.0428
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0117 0.0355
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0283 0.0254
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.595
Brugia malayi hypothetical protein 0.0015 0.0084 0.0167
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0011 0.0001 0.0037
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.003 0.0087
Leishmania major hypothetical protein, conserved 0.0015 0.0084 0.1406
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0484 0.0456
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0084 0.1758
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3649 0.363
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0117 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Echinococcus granulosus GPCR family 2 0.0016 0.0117 0.0353
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0254
Onchocerca volvulus 0.0015 0.0084 0.174
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0267 0.0812
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0117 0.0355
Trypanosoma cruzi hexose transporter 0.0033 0.0493 0.8373
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.1354
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.216 0.6597
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.2061
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0117 0.027
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0169 0.1681
Brugia malayi hypothetical protein 0.0015 0.0084 0.0167
Leishmania major glucose transporter, lmgt3 0.0033 0.0493 0.8373
Leishmania major glucose transporter, lmgt1 0.0033 0.0493 0.8373
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.1475
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.228
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.1429
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0353
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0202 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0484 0.0456
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0117 0.284
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0589 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0438 0.1335
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0117 0.0353
Schistosoma mansoni single-minded 0.0043 0.0733 0.3302
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0202 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0825 0.2517
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Leishmania major protein kinase, putative 0.0013 0.0047 0.0786
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0484 0.0456
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0117 0.0355
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0469 1
Onchocerca volvulus 0.0015 0.0084 0.174
Echinococcus multilocularis Polycystic kidney disease protein 0.0013 0.003 0.0087
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0084 0.1406
Echinococcus multilocularis transfer RNA-Lys 0.0032 0.0476 0.1452
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3649 0.5495
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0117 0.0355
Onchocerca volvulus 0.0015 0.0084 0.174
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.216 0.6597
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0283 0.4801
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0283 0.6033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0155 0.3274 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0154 0.2594
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0283 0.5182
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.1354
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0408
Echinococcus granulosus single minded 2 0.0032 0.0476 0.1452
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Plasmodium vivax hexose transporter 0.0106 0.216 0.2137
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0117 0.0268
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0438 0.1335
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0253
Brugia malayi major facilitator superfamily protein 0.0015 0.0084 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0042 0.0124
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0169 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0084 0.0383
Trypanosoma brucei glucose transporter 2A 0.0033 0.0493 0.8107
Onchocerca volvulus 0.0013 0.003 0.0603
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0922 0.275
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0117 0.0665
Onchocerca volvulus 0.0015 0.0084 0.174
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0469 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0493 0.8373
Echinococcus granulosus RUN 0.0013 0.003 0.0087
Plasmodium falciparum protein kinase 7 0.03 0.6571 0.6561
Loa Loa (eye worm) doublecortin family protein 0.0013 0.003 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.216 1
Leishmania major protein kinase, putative 0.0013 0.0047 0.0786
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0283 0.0862
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Leishmania major glucose transporter, lmgt2 0.0033 0.0493 0.8373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Onchocerca volvulus 0.0015 0.0084 0.174
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0484 0.0456
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0202 0.4295
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.8107
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3649 0.363
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0922 0.2814
Schistosoma mansoni aryl hydrocarbon receptor 0.0043 0.0733 0.3302
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.8373
Brugia malayi isocitrate dehydrogenase 0.0016 0.0117 0.027
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0117 0.1977
Brugia malayi Cytochrome P450 family protein 0.0023 0.0267 0.0731
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0283 0.0254
Treponema pallidum prolyl-tRNA synthetase 0.0011 0 0.5
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.228
Schistosoma mansoni glucose transport protein 0.0106 0.216 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0084 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0484 0.0617
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.1429
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383
Echinococcus multilocularis General substrate transporter 0.0091 0.1821 0.5559
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0589 0.0779
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0484 0.0617
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0922 0.275
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0084 0.0383

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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