Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0117 | 0.0536 |
Brugia malayi | RNA binding protein | 0.0067 | 0.218 | 0.218 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0117 | 0.0117 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.7932 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0851 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.218 | 0.218 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0764 | 0.1259 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.1386 | 0.1386 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.218 | 0.9629 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 0.7932 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0655 | 0.0655 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0655 | 0.2894 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0655 | 0.3005 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0117 | 0.0536 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0655 | 0.3005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.218 | 0.9629 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0851 | 0.0851 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.1386 | 0.6964 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0117 | 0.0117 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.0851 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.1386 | 0.1624 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.365 | 0.365 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1386 | 0.1386 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0117 | 0.0536 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.1386 | 0.1624 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.2264 | 0.2264 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.7932 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.0851 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.1386 | 0.1624 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2264 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.218 | 0.9629 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2264 | 0.2264 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0764 | 0.1259 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.1939 | 0.2332 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0851 | 0.1427 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0655 | 0.2894 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.1386 | 0.1624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.1939 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0247 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.1939 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.1386 | 0.6964 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0199 | 0.7932 | 0.7932 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0655 | 0.3005 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0117 | 0.0516 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.1939 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.1386 | 0.6964 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.1386 | 0.2467 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.1386 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0049 | 0.1386 | 0.1624 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 0.7932 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.1386 | 0.1624 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0655 | 0.0655 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0199 | 0.7932 | 0.7932 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0117 | 0.0536 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.218 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0117 | 0.0536 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.1386 | 0.1624 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.365 | 0.365 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1386 | 0.1386 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.1386 | 0.2467 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0851 | 0.0851 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0117 | 0.0516 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0655 | 0.3005 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.218 | 0.218 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0764 | 0.1259 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.1386 | 0.1624 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.1939 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.365 | 0.365 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0655 | 0.2894 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0036 | 0.0851 | 0.0939 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0655 | 0.3005 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0764 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.365 | 0.365 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0117 | 0.0117 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.218 | 0.9629 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.7932 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.1939 | 0.2332 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.1386 | 0.1624 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0117 | 0.0536 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0655 | 0.3005 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0199 | 0.7932 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.1386 | 0.1624 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0655 | 0.2894 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.218 | 0.218 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0851 | 0.0851 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.1386 | 0.1624 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.218 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0655 | 0.0655 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.218 | 0.218 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0199 | 0.7932 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0655 | 0.0655 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.218 | 0.9629 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0851 | 0.0851 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.1386 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0851 | 0.0851 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.1386 | 0.1386 |
Onchocerca volvulus | 0.0199 | 0.7932 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0247 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.7932 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.1386 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.218 | 0.218 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0138 | 0.5261 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.7932 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0117 | 0.0516 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.7932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1386 | 0.1386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.