Detailed information for compound 667708

Basic information

Technical information
  • TDR Targets ID: 667708
  • Name: 2-(4-chlorophenoxy)-1-(4-methylphenyl)ethanon e
  • MW: 260.716 | Formula: C15H13ClO2
  • H donors: 0 H acceptors: 1 LogP: 4.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)COc1ccc(cc1)Cl
  • InChi: 1S/C15H13ClO2/c1-11-2-4-12(5-3-11)15(17)10-18-14-8-6-13(16)7-9-14/h2-9H,10H2,1H3
  • InChiKey: SPSYWSHMNXKMQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00316808
  • STK123812

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0131 0.1464 0.2071
Schistosoma mansoni endonuclease related 0.0079 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0043 0.0127 0.0127
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.2258 1
Echinococcus multilocularis dna polymerase eta 0.0043 0.0127 0.0127
Leishmania major hypothetical protein, conserved 0.0057 0.0326 0.4898
Onchocerca volvulus 0.0183 0.2258 0.479
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1875 0.1875
Echinococcus granulosus Endonuclease G 0.0079 0.0666 0.0666
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0363 0.0363
Schistosoma mansoni alpha-glucosidase 0.0136 0.154 0.154
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0363 0.5456
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0111 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0131 0.1464 0.1464
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0363 0.5456
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0326 0.4898
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1875 0.1875
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0363 0.0363
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1875 0.1875
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.2258 1
Schistosoma mansoni hypothetical protein 0.0165 0.1972 0.1972
Loa Loa (eye worm) hypothetical protein 0.0131 0.1464 0.1464
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Onchocerca volvulus 0.0131 0.1464 0.2071
Brugia malayi endonuclease G, mitochondrial precursor 0.0079 0.0666 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0326 0.4898
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0692 1 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0111 0.115 0.115
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0131 0.1464 0.1464
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.2258 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus multilocularis geminin 0.0165 0.1972 0.1972
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0079 0.0666 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.2258 1
Trypanosoma cruzi endonuclease G, putative 0.0079 0.0666 1
Echinococcus multilocularis ectonucleotide 0.0111 0.115 0.115
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0079 0.0666 1
Echinococcus multilocularis Endonuclease G 0.0079 0.0666 0.0666
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0183 0.2258 0.2258
Leishmania major endonuclease G, putative 0.0079 0.0666 1
Brugia malayi Thrombospondin type 1 domain containing protein 0.0283 0.378 0.378
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0326 0.1445
Trypanosoma brucei endonuclease G, putative 0.0079 0.0666 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0127 0.1397 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0131 0.1464 0.1464
Loa Loa (eye worm) hypothetical protein 0.0131 0.1464 0.1464
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0326 0.4898
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus granulosus geminin 0.0165 0.1972 0.1972
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0283 0.378 0.378
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.2258 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0131 0.1464 0.1464
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0127 0.1914
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.2258 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0326 0.1445
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1875 0.1875
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0183 0.2258 0.2258
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0363 0.0363
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Trypanosoma brucei endonuclease G, putative 0.0079 0.0666 1
Leishmania major DNA polymerase eta, putative 0.0043 0.0127 0.1914
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0183 0.2258 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0363 0.0363
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0692 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.1972 0.1972
Echinococcus granulosus dna polymerase eta 0.0043 0.0127 0.0127
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Schistosoma mansoni alpha-glucosidase 0.0136 0.154 0.154
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0127 0.1914
Echinococcus granulosus ectonucleotide 0.0111 0.115 0.115
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0079 0.0666 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0079 0.0666 1
Schistosoma mansoni DNA polymerase eta 0.0043 0.0127 0.0127
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0127 0.0127
Onchocerca volvulus 0.0283 0.378 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1875 0.1875
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.2258 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0131 0.1464 0.1464
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0183 0.2258 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.2258 1
Trypanosoma brucei endonuclease G, putative 0.0079 0.0666 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0692 1 1
Trypanosoma cruzi endonuclease G, putative 0.0079 0.0666 1
Schistosoma mansoni hypothetical protein 0.0283 0.378 0.378
Loa Loa (eye worm) hypothetical protein 0.0111 0.115 0.115
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0692 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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