Detailed information for compound 668253

Basic information

Technical information
  • TDR Targets ID: 668253
  • Name: N-(3-chloro-4-fluorophenyl)-3-(phenylmethoxy) benzamide
  • MW: 355.79 | Formula: C20H15ClFNO2
  • H donors: 1 H acceptors: 1 LogP: 4.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)OCc1ccccc1)Nc1ccc(c(c1)Cl)F
  • InChi: 1S/C20H15ClFNO2/c21-18-12-16(9-10-19(18)22)23-20(24)15-7-4-8-17(11-15)25-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,23,24)
  • InChiKey: UTSGWSCIYDQNBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chloro-4-fluoro-phenyl)-3-(phenylmethoxy)benzamide
  • 3-(benzyloxy)-N-(3-chloro-4-fluoro-phenyl)benzamide
  • Oprea1_016310
  • STK209414
  • 3-Benzyloxy-N-(3-chloro-4-fluoro-phenyl)-benzamide
  • BAS 04437052
  • ZINC00782902

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.1065 0.1216
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0458 0.9538 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0457 0.0428
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Toxoplasma gondii exonuclease III APE 0.0019 0.0171 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1065 0.8828
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0457 0.0522
Treponema pallidum polypeptide deformylase (def) 0.0458 0.9538 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1065 0.8828
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0097 0.1851 0.2114
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0458 0.9538 1
Chlamydia trachomatis peptide deformylase 0.0458 0.9538 0.5
Plasmodium vivax peptide deformylase, putative 0.0458 0.9538 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Schistosoma mansoni ap endonuclease 0.0019 0.0171 0.0762
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0457 0.0479
Schistosoma mansoni hypothetical protein 0.0031 0.0433 0.3128
Toxoplasma gondii ABC1 family protein 0.0032 0.0457 0.0479
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0458 0.9538 1
Brugia malayi beta-lactamase family protein 0.0032 0.0457 0.0428
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0015 0.0086 0.0086
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3501 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0015 0.0086 0.0086
Schistosoma mansoni ap endonuclease 0.0019 0.0171 0.0762
Schistosoma mansoni hypothetical protein 0.0067 0.1195 1
Leishmania major hypothetical protein, conserved 0.0032 0.0457 0.086
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.0457 0.0479
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0457 0.0457
Brugia malayi beta-lactamase family protein 0.0032 0.0457 0.0428
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0171 0.0179
Leishmania major polypeptide deformylase-like protein, putative 0.0175 0.3501 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0478 0.0923
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0478 0.4004
Schistosoma mansoni hypothetical protein 0.0031 0.0433 0.3128
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0433 0.04
Brugia malayi Pre-SET motif family protein 0.006 0.1065 0.1128
Plasmodium falciparum peptide deformylase 0.0458 0.9538 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3501 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0478 0.0478
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1851 0.2114
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0171 0.0097
Trypanosoma brucei Polypeptide deformylase 1 0.0175 0.3501 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0171 0.0179
Trichomonas vaginalis set domain proteins, putative 0.048 1 1
Onchocerca volvulus 0.006 0.1065 0.0637
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Loa Loa (eye worm) transcription factor SMAD2 0.0046 0.0752 0.0858
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1851 0.2035
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0392 0.0392
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1851 0.2035
Schistosoma mansoni hypothetical protein 0.0031 0.0433 0.3128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0433 0.3543
Mycobacterium ulcerans peptide deformylase 0.0458 0.9538 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0171 0.0171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0433 0.3543
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0457 0.0457
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0478 0.4004
Mycobacterium ulcerans beta-lactamase 0.0032 0.0457 0.0479
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0171 0.0179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0433 0.3543
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0457 0.0457
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.0457 0.0479
Plasmodium vivax SET domain protein, putative 0.006 0.1065 0.1116
Mycobacterium ulcerans lipase LipD 0.0032 0.0457 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1065 0.8828
Mycobacterium ulcerans hypothetical protein 0.0032 0.0457 0.0479
Mycobacterium leprae Probable lipase LipE 0.0032 0.0457 0.0479
Loa Loa (eye worm) MH2 domain-containing protein 0.0046 0.0752 0.0858
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0457 0.086
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Brugia malayi beta-lactamase 0.0032 0.0457 0.0428
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0171 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1065 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0433 0.3543
Echinococcus multilocularis GPCR, family 2 0.0031 0.0433 0.3543
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0478 0.0923
Toxoplasma gondii hypothetical protein 0.0029 0.0392 0.0411
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0457 0.0479
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0255 0.0255
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0457 0.0479
Trypanosoma cruzi Peptide deformylase 2, putative 0.0175 0.3501 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0433 0.04
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0457 0.3791
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1065 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0175 0.3501 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Toxoplasma gondii hypothetical protein 0.0458 0.9538 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0255 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1065 0.8828
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0171 0.5
Mycobacterium tuberculosis Conserved protein 0.0032 0.0457 0.0479
Echinococcus granulosus GPCR family 2 0.0031 0.0433 0.3543
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0457 0.0479
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0478 0.0478
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0478 0.0923
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.1017 0.9516
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0392 0.0392
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0457 0.0479
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0478 0.0923
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0015 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0171 0.0863
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0457 0.0457
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.8759 1
Schistosoma mansoni hypothetical protein 0.0031 0.0433 0.3128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0457 0.3346
Mycobacterium tuberculosis Conserved protein 0.0032 0.0457 0.0479
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0171 0.0195
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0171 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0457 0.3346
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0392 0.0392
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1065 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0457 0.3791
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0457 0.0479
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0478 0.0923
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1195 0.1278
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0015 0.0086 0.0098
Mycobacterium tuberculosis Conserved protein 0.0032 0.0457 0.0479
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0457 0.0479
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0204 0.4126 0.4325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0433 0.0494
Brugia malayi MH2 domain containing protein 0.0046 0.0752 0.0767
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1065 0.1116
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0457 0.0479
Trypanosoma brucei Peptide deformylase 2 0.0175 0.3501 1
Trichomonas vaginalis esterase, putative 0.0032 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0067 0.1195 0.1364
Loa Loa (eye worm) hypothetical protein 0.0031 0.0433 0.0494
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0457 0.086
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0457 0.086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0522
Brugia malayi Pre-SET motif family protein 0.0422 0.8759 1
Loa Loa (eye worm) beta-lactamase 0.0032 0.0457 0.0522
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0478 0.0478
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0457 0.0479
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0255 0.0252
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0033 0.0478 0.3535
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0171 0.0863
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0033 0.0478 0.0478

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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