TDR Targets

Basic information

Technical information

TDR Targets ID: 670620
Name: (4-propan-2-ylpiperazin-1-yl)-thiophen-2-ylme thanone
MW: 238.349 | Formula: C12H18N2OS
H donors: 0 H acceptors: 1 LogP: 2.01 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(N1CCN(CC1)C(=O)c1cccs1)C
InChi: 1S/C12H18N2OS/c1-10(2)13-5-7-14(8-6-13)12(15)11-4-3-9-16-11/h3-4,9-10H,5-8H2,1-2H3
InChiKey: ZEVVAPJSMUTCRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-isopropylpiperazin-1-yl)-(2-thienyl)methanone
(4-isopropyl-1-piperazinyl)-(2-thienyl)methanone
(4-propan-2-ylpiperazin-1-yl)-thiophen-2-yl-methanone
AG-690/40720062
Oprea1_496293
(4-Isopropyl-piperazin-1-yl)-thiophen-2-yl-methanone
BAS 01376033
Oprea1_709681
ST5008973

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.0434	0.1531
Leishmania major	metacaspase, putative	0.0088	0.1095	0.2012
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	0.7742
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	1
Echinococcus granulosus	caspase	0.0232	0.4113	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.1536	0.6011
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.1357	0.33
Echinococcus granulosus	geminin	0.0166	0.273	0.6637
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0309	0.1023
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.1357	0.33
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0281	0.0281
Onchocerca volvulus		0.0095	0.1249	0.038
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0309	0.0752
Trypanosoma cruzi	metacaspase 5, putative	0.0088	0.1095	0.2012
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1357	0.33
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0258	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1249	0.1249
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.1536	0.6011
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0303	0.0737
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	0.3325
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0258	0.0627
Mycobacterium ulcerans	integral membrane protein	0.0038	0.0058	0.0088
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0536	0.1303
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.179	0.7044
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0861	0.2094
Brugia malayi	Trypsin family protein	0.0095	0.1249	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0185	0.3128	0.3128
Trypanosoma cruzi	metacaspase, putative	0.0088	0.1095	0.2012
Schistosoma mansoni	alpha-glucosidase	0.0137	0.2132	0.5182
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0082	0.0969	0.2357
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0496	0.1206
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0129	0.0237
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0088	0.1095	0.807
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0496	0.1206
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0303	0.0737
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0337	0.6307	0.7251
Echinococcus multilocularis	Protein lozenge	0.0054	0.0397	0.0966
Echinococcus multilocularis	caspase 2	0.017	0.2805	0.6819
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0536	0.1303
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0303	0.0557
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0303	0.0737
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0036	0.0088
Brugia malayi	hypothetical protein	0.0082	0.0969	0.0969
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0258	0.1899
Brugia malayi	follicle stimulating hormone receptor	0.0227	0.4003	0.4003
Trypanosoma brucei	trypanothione reductase	0.0048	0.0258	0.0473
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.179	1
Schistosoma mansoni	hypothetical protein	0.0166	0.273	0.6637
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0185	0.3128	0.3128
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1249	0.1249
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	1
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Mycobacterium tuberculosis	Probable reductase	0.0109	0.1536	0.6011
Echinococcus granulosus	caspase 3	0.0144	0.2278	0.5537
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0612	0.1487
Echinococcus multilocularis	CAAX prenyl protease 2	0.0185	0.3128	0.7604
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0036	0.0265
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0861	0.6345
Brugia malayi	MAP kinase sur-1	0.005	0.0303	0.0303
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0036	0.0066
Brugia malayi	Glycosyl hydrolases family 31 protein	0.016	0.2596	0.2596
Giardia lamblia	Hypothetical protein	0.0185	0.3128	1
Trypanosoma brucei	protein kinase, putative	0.005	0.0303	0.0557
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0861	0.3725
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0185	0.3128	0.5745
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2187	0.4016
Leishmania major	trypanothione reductase	0.0048	0.0258	0.0473
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0513	1	1
Schistosoma mansoni	hypothetical protein	0.0082	0.0969	0.2357
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0258	0.0258
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0088	0.1095	0.807
Echinococcus granulosus	lysosomal alpha glucosidase	0.016	0.2596	0.6312
Echinococcus multilocularis	caspase 3	0.0144	0.2278	0.5537
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.2596	0.6312
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0303	0.0303
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0258	0.0627
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Entamoeba histolytica	CAAX amino terminal protease family	0.0038	0.0058	0.0185
Echinococcus granulosus	CAAX prenyl protease 2	0.0185	0.3128	0.7604
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0303	0.0303
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0232	0.4113	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0536	0.0984
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0496	0.1206
Onchocerca volvulus		0.0089	0.1119	0.0204
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1357	0.33
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0185	0.3128	0.5745
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0185	0.3128	0.5745
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0281	0.0281
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0232	0.4113	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0658	0.0658
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0185	0.3128	0.7604
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0185	0.3128	0.5745
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.5445	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Loa Loa (eye worm)	inositol-1	0.0037	0.0036	0.0036
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.2518	1
Loa Loa (eye worm)	hypothetical protein	0.0434	0.8331	0.8331
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0129	0.0237
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0036	0.0036
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0303	0.0303
Plasmodium falciparum	glutathione reductase	0.0048	0.0258	0.1926
Loa Loa (eye worm)	hypothetical protein	0.0434	0.8331	0.8331
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0258	0.1926
Trypanosoma brucei	metacaspase MCA3	0.0088	0.1095	0.2012
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0612	0.1123
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.0434	0.0798
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0058	0.0088
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.0434	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0281	0.0281
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0258	0.1926
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0036	0.0088
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0036	0.0066
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0303	0.2233
Trypanosoma brucei	metacaspase 5, putative	0.0088	0.1095	0.2012
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0612	0.1487
Trypanosoma cruzi	metacaspase 5, putative	0.0088	0.1095	0.2012
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	0.3325
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.1249	0.3036
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.1536	0.6011
Toxoplasma gondii	hypothetical protein	0.0038	0.0058	0.0426
Schistosoma mansoni	caspase-3 (C14 family)	0.0232	0.4113	1
Toxoplasma gondii	hypothetical protein	0.0038	0.0058	0.0426
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0612	0.1123
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0258	0.0473
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0496	0.1206
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0258	0.0258
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0861	0.2094
Brugia malayi	hypothetical protein	0.0434	0.8331	0.8331
Trypanosoma brucei	metacaspase MCA2	0.0088	0.1095	0.2012
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0036	0.0066
Trypanosoma cruzi	metacaspase, putative	0.0088	0.1095	0.2012
Echinococcus multilocularis	caspase 8	0.0088	0.1095	0.2663
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0185	0.3128	0.7604
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0612	0.0612
Brugia malayi	Probable ClpP-like protease	0.0077	0.0861	0.0861
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0036	0.0115
Echinococcus granulosus	caspase 8	0.0088	0.1095	0.2663
Trypanosoma cruzi	metacaspase, putative	0.0088	0.1095	0.2012
Trichomonas vaginalis	glucosylceramidase, putative	0.0355	0.6686	0.6686
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0536	0.2015
Brugia malayi	jmjC domain containing protein	0.0059	0.0496	0.0496
Entamoeba histolytica	CAAX prenyl protease family	0.0185	0.3128	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0612	0.1123
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0227	0.4003	0.4003
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Onchocerca volvulus		0.0092	0.1189	0.0299
Schistosoma mansoni	caspase-7 (C14 family)	0.0232	0.4113	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0355	0.6686	0.6686
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0536	0.2015
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0434	0.0434
Entamoeba histolytica	CAAX amino terminal protease family	0.0038	0.0058	0.0185
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.2596	0.6312
Brugia malayi	jmjC domain containing protein	0.0059	0.0496	0.0496
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Toxoplasma gondii	hypothetical protein	0.0048	0.0257	0.1895
Echinococcus multilocularis	geminin	0.0166	0.273	0.6637
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0355	0.0355
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0536	0.2015
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0536	0.3949
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0536	0.1303
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0658	0.1601
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0036	0.0088
Echinococcus granulosus	apoptotic protease activating factor 1	0.0082	0.0969	0.2357
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.1536	0.8285
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0129	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0303	0.0737
Schistosoma mansoni	hypothetical protein	0.0166	0.273	0.6637
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.179	0.7044
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0129	0.0237
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0536	0.1303
Loa Loa (eye worm)	hypothetical protein	0.017	0.2805	0.2805
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.1095	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0612	0.1955
Echinococcus multilocularis	caspase	0.0232	0.4113	1
Loa Loa (eye worm)	runx1	0.0054	0.0397	0.0397
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1095	0.1095
Brugia malayi	Inositol-1	0.0037	0.0036	0.0036
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0281	0.0281
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0861	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0861	0.0861
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0303	0.0557
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1357	0.33
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0309	0.0752
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.032	0.0587
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0434	0.1056
Onchocerca volvulus	Cell death protein 3 homolog	0.017	0.2805	0.2494
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.179	0.7044
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0496	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0969	0.0969
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0612	0.0612
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0303	0.0303
Schistosoma mansoni	caspase-7 (C14 family)	0.017	0.2805	0.6819
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2187	0.4016
Leishmania major	mitochondrial DNA polymerase beta	0.0296	0.5445	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0861	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	1	1
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0058	0.0088
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.5445	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0303	0.0557
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0036	0.0066
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0088	0.1095	0.807
Plasmodium falciparum	metacaspase-like protein	0.0088	0.1095	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0536	0.1944
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0861	0.6345
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.2187	0.4016
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0303	0.0557
Plasmodium vivax	metacaspase 1, putative	0.0088	0.1095	1
Brugia malayi	Melibiase family protein	0.0067	0.0658	0.0658
Brugia malayi	glutathione reductase	0.0048	0.0258	0.0258
Schistosoma mansoni	alpha-glucosidase	0.0137	0.2132	0.5182
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.1536	0.6011
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0258	0.1926
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0303	0.0737
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0434	0.1056
Plasmodium falciparum	metacaspase 1	0.0088	0.1095	1
Trypanosoma brucei	Metacaspase-4	0.0088	0.1095	0.2012
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0303	0.0557
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Toxoplasma gondii	melibiase subfamily protein	0.01	0.1357	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1095	0.1095
Brugia malayi	CAAX amino terminal protease family protein	0.0185	0.3128	0.3128
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.1536	0.6011
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0434	0.1606
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0088	0.1095	0.1095
Mycobacterium ulcerans	hypothetical protein	0.0156	0.2518	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0496	0.0496
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0612	0.1487
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1357	0.33
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.016	0.2596	0.2596
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0038	0.0058	0.0426
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.1357	0.33
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0303	0.0557
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0612	0.1123
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0088	0.1095	0.2663
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0861	0.7742
Trypanosoma brucei	metacaspase	0.0088	0.1095	0.2012
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0042	0.0102
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0303	0.0303
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0042	0.0102
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0496	0.1206
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0296	0.5445	1
Brugia malayi	Cell death protein 3 precursor	0.017	0.2805	0.2805
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0303	0.0557
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0658	0.1601
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.0658	0.0658
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.1249	0.3036
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0036	0.0088
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0434	0.1606
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0309	0.1023
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0496	0.1206
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0036	0.0036
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307
Echinococcus granulosus	caspase 2	0.017	0.2805	0.6819
Trypanosoma cruzi	metacaspase, putative	0.0088	0.1095	0.2012
Brugia malayi	Thioredoxin reductase	0.0048	0.0258	0.0258
Onchocerca volvulus		0.0434	0.8331	1
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0088	0.1095	0.1095
Schistosoma mansoni	lozenge	0.0054	0.0397	0.0966
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.6307	0.6307

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 670620