Detailed information for compound 672268

Basic information

Technical information
  • TDR Targets ID: 672268
  • Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(2-ethylph enoxy)acetamide
  • MW: 343.417 | Formula: C20H25NO4
  • H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNC(=O)COc2ccccc2CC)ccc1OC
  • InChi: 1S/C20H25NO4/c1-4-16-7-5-6-8-17(16)25-14-20(22)21-12-11-15-9-10-18(23-2)19(13-15)24-3/h5-10,13H,4,11-12,14H2,1-3H3,(H,21,22)
  • InChiKey: FZNAKYMYHYUWGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(2-ethylphenoxy)ethanamide
  • ZINC00131143
  • Oprea1_354197

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Heterochromatin protein 1 0.007 0.1257 0.5241
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0121 0.019
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 0.0406
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0388 0.061
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0388 0.0955
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0404 0.0617
Echinococcus granulosus peregrin 0.0029 0.0327 0.0853
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0201 0.0316
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0201 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0121 0.2369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0327 0.5252
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0046 0.0192
Trichomonas vaginalis chromobox protein, putative 0.007 0.1257 0.1974
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0404 0.0404
Echinococcus multilocularis peregrin 0.0029 0.0327 0.0853
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0388 0.061
Schistosoma mansoni jumonji domain containing protein 0.0076 0.14 0.3652
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0413 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0554 0.087
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1257 0.5241
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0468 0.1221
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 1
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.012
Echinococcus granulosus chromobox protein 1 0.007 0.1257 0.3281
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.2936 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0327 0.0327
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0388 0.1014
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0388 0.1619
Trypanosoma cruzi hexose transporter 0.0033 0.0413 0.8107
Leishmania major glucose transporter, lmgt2 0.0033 0.0413 0.8107
Schistosoma mansoni hypothetical protein 0.0182 0.3832 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0121 0.0503
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0497 0.2071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.012
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0201 0.0316
Echinococcus multilocularis chromobox protein 1 0.007 0.1257 0.3281
Trypanosoma cruzi hexose transporter, putative 0.0018 0.007 0.1383
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0046 0.0192
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0201 0.0525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0622 0.0977
Plasmodium vivax hexose transporter 0.0106 0.2094 0.2094
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0201 0.0201
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0121 0.019
Brugia malayi Bromodomain containing protein 0.0029 0.0327 0.1363
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0404 0.0404
Plasmodium vivax CDK-related protein kinase 6, putative 0.0451 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.012
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0201 0.0525
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2094 0.5465
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0292 0.0459
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0201 0.0291
Trichomonas vaginalis chromobox protein, putative 0.007 0.1257 0.1974
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.2936 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0121 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2094 0.3201
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.012
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0201 0.0308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0046 0.0192
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0404 0.7919
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0404 0.1682
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0404 0.1682
Schistosoma mansoni protein kinase 0.0033 0.0404 0.1053
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.185 0.4828
Loa Loa (eye worm) hypothetical protein 0.0031 0.036 0.1503
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Echinococcus granulosus General substrate transporter 0.0091 0.1752 0.4571
Echinococcus granulosus chromobox protein 1 0.007 0.1257 0.3281
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0121 0.0121
Giardia lamblia PHD finger protein 15 0.0029 0.0327 0.0513
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0201 0.395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0201 0.0839
Loa Loa (eye worm) sugar transporter 0.0106 0.2094 0.8729
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0404 0.0634
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0201 0.0686
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0388 0.0428
Toxoplasma gondii exonuclease III APE 0.002 0.0121 0.0185
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0404 0.0404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0886 0.3691
Leishmania major glucose transporter, lmgt1 0.0033 0.0413 0.8107
Echinococcus granulosus GPCR family 2 0.0017 0.0046 0.012
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0388 0.1619
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0468 0.1221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0497 0.2071
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0413 0.0649
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.051 0.051
Echinococcus multilocularis geminin 0.0182 0.3832 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0327 0.05
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0413 0.8107
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.005 0.0805 0.3356
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0121 0.2369
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0201 0.0201
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0121 0.0411
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0201 0.0525
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.0933
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0404 0.1682
Brugia malayi jmjC domain containing protein 0.0035 0.0468 0.195
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0121 0.019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0327 0.1363
Entamoeba histolytica protein kinase, putative 0.0033 0.0404 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0413 0.0649
Plasmodium falciparum proline--tRNA ligase 0.0037 0.051 0.051
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.051 0.0779
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0413 0.8107
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0413 0.0649
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0327 0.1363
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0327 0.05
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.051 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0388 0.1014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0121 0.2369
Brugia malayi MH2 domain containing protein 0.0119 0.2399 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 0.0406
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0413 0.8107
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0201 0.0686
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0468 0.1221
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0413 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0404 0.0617
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2399 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0404 0.0617
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0404 0.0404
Echinococcus multilocularis GPCR, family 2 0.0017 0.0046 0.012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0413 0.8107
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0121 0.2369
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0292 0.0459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0554 0.231
Schistosoma mansoni ap endonuclease 0.002 0.0121 0.0315
Leishmania major glucose transporter, lmgt3 0.0033 0.0413 0.8107
Schistosoma mansoni glucose transport protein 0.0106 0.2094 0.5465
Toxoplasma gondii protein kinase, putative 0.03 0.6542 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0886 0.3691
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0589 0.1537
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.051 1
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.6369 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Schistosoma mansoni chromobox protein 0.007 0.1257 0.3281
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0404 0.1053
Brugia malayi chromobox protein homolog 3 0.0039 0.0554 0.231
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.1048
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0121 0.0503
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0622 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.6369 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.0933
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0404 0.0404
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0404 0.0404
Schistosoma mansoni hypothetical protein 0.0106 0.2094 0.5465
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0121 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0404 0.1053
Entamoeba histolytica hypothetical protein 0.0024 0.0201 0.0129
Leishmania major protein kinase, putative 0.0033 0.0404 0.7919
Schistosoma mansoni protein kinase 0.0033 0.0404 0.1053
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0327 0.0327
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0886 0.3691
Schistosoma mansoni ap endonuclease 0.002 0.0121 0.0315
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.6369 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0413 0.0649
Trypanosoma brucei glucose transporter 1E 0.0033 0.0413 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0201 0.395
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3595 0.5495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Plasmodium falciparum protein kinase 7 0.03 0.6542 0.6542
Brugia malayi jmjC domain containing protein 0.0096 0.185 0.7712
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0327 0.0853
Schistosoma mansoni chromobox protein 0.007 0.1257 0.3281
Plasmodium falciparum hexose transporter 0.0106 0.2094 0.2094
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0589 0.1537
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0201 0.0839
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.6369 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0201 0.0525
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0886 0.3691
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0327 0.0853
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3595 0.3595
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0201 0.395
Schistosoma mansoni glucose transport protein 0.0106 0.2094 0.5465
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0388 0.1014
Schistosoma mansoni protein kinase 0.0033 0.0404 0.1053
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2399 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0413 0.0649
Schistosoma mansoni hypothetical protein 0.0037 0.0497 0.1297
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.104 0.4334
Brugia malayi Cam kinase protein 1 0.0033 0.0404 0.1682
Brugia malayi Sugar transporter family protein 0.0106 0.2094 0.8729
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0404 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0413 0.8107
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Schistosoma mansoni glucose transport protein 0.0106 0.2094 0.5465
Loa Loa (eye worm) hypothetical protein 0.0033 0.0404 0.1682
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Echinococcus multilocularis chromobox protein 1 0.007 0.1257 0.3281
Trypanosoma brucei glucose transporter 2A 0.0033 0.0413 0.8107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0468 0.1221
Loa Loa (eye worm) hypothetical protein 0.0032 0.0388 0.1619
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0388 0.1014
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0622 0.0977
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0121 0.0411
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.2936 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0413 0.8107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2094 0.3288
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0327 0.0853
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0468 0.195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0121 0.0315
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Brugia malayi PHD-finger family protein 0.0029 0.0327 0.1363
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0554 0.087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0192
Onchocerca volvulus 0.0031 0.036 0.5792
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0413 0.0649
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0404 0.0404
Echinococcus multilocularis General substrate transporter 0.0091 0.1752 0.4571
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0134 0.0211
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.185 0.4828
Loa Loa (eye worm) hypothetical protein 0.0032 0.0388 0.1619
Entamoeba histolytica protein kinase, putative 0.0033 0.0404 0.0453
Schistosoma mansoni hypothetical protein 0.0182 0.3832 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3595 0.3595
Trypanosoma brucei glucose transporter, putative 0.0033 0.0413 0.8107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.6369 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2094 0.5465
Echinococcus granulosus geminin 0.0182 0.3832 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0404 0.1053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0121 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0554 0.8906
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.012
Schistosoma mansoni hypothetical protein 0.0029 0.0327 0.0853

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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