Detailed information for compound 673067

Basic information

Technical information
  • TDR Targets ID: 673067
  • Name: 3-(3-fluorophenyl)-1-(2,2,6,6-tetramethylpipe ridin-4-yl)thiourea
  • MW: 309.445 | Formula: C16H24FN3S
  • H donors: 3 H acceptors: 0 LogP: 2.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1cccc(c1)F)NC1CC(C)(C)NC(C1)(C)C
  • InChi: 1S/C16H24FN3S/c1-15(2)9-13(10-16(3,4)20-15)19-14(21)18-12-7-5-6-11(17)8-12/h5-8,13,20H,9-10H2,1-4H3,(H2,18,19,21)
  • InChiKey: SDPZPRWZAYKCOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-fluorophenyl)-1-(2,2,6,6-tetramethyl-4-piperidyl)thiourea
  • 3-(3-fluorophenyl)-1-(2,2,6,6-tetramethyl-4-piperidinyl)thiourea
  • STK144322

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0294 0.0294
Schistosoma mansoni intermediate filament proteins 0.0028 0.0624 0.062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0294 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0203 0.0203
Echinococcus multilocularis lamin dm0 0.0028 0.0624 0.0624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0294 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0294 0.5
Schistosoma mansoni survival motor neuron protein 0.005 0.1576 0.202
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0294 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1694 0.1694
Echinococcus multilocularis lamin 0.0028 0.0624 0.0624
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.2705 0.3681
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1899 0.1846
Schistosoma mansoni hypothetical protein 0.0177 0.7001 1
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.244 0.3291
Brugia malayi intermediate filament protein 0.0028 0.0624 0.0564
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.244 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0203 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0294 0.0294
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0203 0.0203
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0203 0.0203
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0203 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1694 0.2194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1694 0.1694
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0203 0.0203
Brugia malayi hypothetical protein 0.0077 0.2705 0.2658
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1694 0.1641
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0624 0.0564
Echinococcus granulosus lamin dm0 0.0028 0.0624 0.0624
Entamoeba histolytica hypothetical protein 0.0077 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0602 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0294 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0294 0.0232
Loa Loa (eye worm) hypothetical protein 0.0028 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0058 0.1899 0.1899
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.244 0.244
Echinococcus multilocularis survival motor neuron protein 1 0.0247 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1694 0.2194
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0294 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.244 1
Entamoeba histolytica hypothetical protein 0.0077 0.2705 1
Echinococcus granulosus survival motor neuron protein 1 0.0247 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1694 0.1694
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.2705 0.2705
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.244 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0203 0.0203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1899 0.1846
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1576 0.1522
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.2705 0.2705
Echinococcus granulosus lamin 0.0028 0.0624 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.1114 0.1056
Loa Loa (eye worm) hypothetical protein 0.004 0.1114 0.1114
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0294 0.5
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0624 0.0624
Schistosoma mansoni ap endonuclease 0.002 0.0294 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.244 1
Schistosoma mansoni lamin 0.0028 0.0624 0.062
Echinococcus granulosus geminin 0.0177 0.7001 0.7001
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.244 0.3291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1694 0.1694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1694 0.1694
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0294 0.0294
Entamoeba histolytica hypothetical protein 0.0077 0.2705 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0294 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1899 0.1899
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.244 1
Schistosoma mansoni hypothetical protein 0.0077 0.2705 0.3681
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0624 0.0624
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0294 0.5
Echinococcus granulosus GPCR family 2 0.0018 0.0203 0.0203
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0064 0.0064
Echinococcus multilocularis musashi 0.0028 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.005 0.1576 0.202
Echinococcus multilocularis GPCR, family 2 0.0018 0.0203 0.0203
Schistosoma mansoni ap endonuclease 0.002 0.0294 0.0135
Echinococcus granulosus intermediate filament protein 0.0028 0.0624 0.0624
Schistosoma mansoni lamin 0.0028 0.0624 0.062
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0294 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.244 1
Entamoeba histolytica hypothetical protein 0.0077 0.2705 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0203 0.0139
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.244 0.244
Onchocerca volvulus 0.005 0.1576 1
Loa Loa (eye worm) hypothetical protein 0.0247 1 1
Schistosoma mansoni hypothetical protein 0.0177 0.7001 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1694 0.2194
Schistosoma mansoni hypothetical protein 0.004 0.1114 0.134
Echinococcus multilocularis geminin 0.0177 0.7001 0.7001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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