Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0564 | 0.034 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6981 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Echinococcus granulosus | lamin | 0.003 | 0.0564 | 0.034 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.2084 | 0.2745 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.2658 | 0.3594 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.2084 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0232 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.0564 | 0.034 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0564 | 0.0564 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.2084 | 0.2745 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.2084 | 0.1896 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0564 | 0.0564 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0232 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0232 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0082 | 0.2658 | 0.3594 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0564 | 0.0492 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0232 | 0.5 |
Schistosoma mansoni | lamin | 0.003 | 0.0564 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6981 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0564 | 0.0564 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1522 | 0.1911 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Brugia malayi | hypothetical protein | 0.0082 | 0.2658 | 0.2658 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0564 | 0.0564 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0232 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0564 | 0.034 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1522 | 0.1911 |
Echinococcus multilocularis | geminin | 0.019 | 0.6981 | 0.691 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0082 | 0.2658 | 0.2484 |
Onchocerca volvulus | 0.0054 | 0.1522 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0564 | 0.034 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.0564 | 0.034 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0082 | 0.2658 | 0.2484 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0232 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.2658 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.2084 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.0564 | 0.0492 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1522 | 0.1522 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0232 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.2084 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Echinococcus granulosus | geminin | 0.019 | 0.6981 | 0.691 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0232 | 0.0232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.