Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0564 | 0.0564 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1522 | 0.1911 |
Echinococcus multilocularis | geminin | 0.0179 | 0.6981 | 0.691 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0564 | 0.034 |
Onchocerca volvulus | 0.0051 | 0.1522 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.2658 | 0.2484 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0564 | 0.034 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0564 | 0.034 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.2658 | 0.2484 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0232 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1522 | 0.1522 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0492 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.2084 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0179 | 0.6981 | 0.691 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0232 | 0.0232 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0564 | 0.034 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.6981 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2658 | 0.3594 |
Echinococcus granulosus | lamin | 0.0028 | 0.0564 | 0.034 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2084 | 0.2745 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0232 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.2084 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0564 | 0.034 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2084 | 0.2745 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.2084 | 0.1896 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0564 | 0.0564 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0564 | 0.0564 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0232 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.2658 | 0.3594 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0564 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.6981 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0492 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1522 | 0.1911 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2658 | 0.2658 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.