Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0083 | 0.6416 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0149 | 0.0149 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0603 | 0.3002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0701 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0053 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0083 | 0.0083 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0083 | 0.5587 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0149 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0083 | 0.5587 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0083 | 0.5587 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0053 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.0701 | 0.0701 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.06 | 0.2987 | 0.2991 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0149 | 0.0149 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0083 | 0.6416 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0149 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0083 | 0.5587 |
Loa Loa (eye worm) | hypothetical protein | 0.1989 | 0.9985 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0149 | 0.0495 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0083 | 0.5587 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0049 | 0.3749 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1992 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0149 | 0.0149 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0149 | 0.0149 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0053 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0083 | 0.5587 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0053 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1992 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0083 | 0.6416 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0603 | 0.3002 | 0.3006 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0083 | 0.5587 |
Schistosoma mansoni | protein kinase | 0.1992 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0149 | 0.0495 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0701 | 0.0702 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0603 | 0.3002 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0805 | 0.0805 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0049 | 0.3749 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0149 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0083 | 0.5587 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0149 | 0.0149 |
Echinococcus granulosus | geminin | 0.0167 | 0.0805 | 0.0805 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0149 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0049 | 0.3749 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0083 | 0.5587 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0083 | 0.5587 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0053 | 0.3588 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0083 | 0.5587 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.0701 | 0.0701 |
Onchocerca volvulus | 0.0023 | 0.0083 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0053 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0805 | 0.0805 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0053 | 0.412 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0083 | 0.5587 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0049 | 0.3749 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0149 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0149 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0149 | 0.0149 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0053 | 0.0053 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0083 | 0.6416 |
Schistosoma mansoni | protein kinase | 0.1992 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0129 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0083 | 0.0083 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0793 | 0.3959 | 0.3959 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0083 | 0.5587 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0083 | 0.0083 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0083 | 0.0083 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0083 | 0.5587 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0053 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0805 | 0.0805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.