Detailed information for compound 675719

Basic information

Technical information
  • TDR Targets ID: 675719
  • Name: 5-(2,3-dichlorophenyl)-N-(2,4-dimethoxyphenyl )furan-2-carboxamide
  • MW: 392.233 | Formula: C19H15Cl2NO4
  • H donors: 1 H acceptors: 1 LogP: 5.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)c1ccc(o1)c1cccc(c1Cl)Cl
  • InChi: 1S/C19H15Cl2NO4/c1-24-11-6-7-14(17(10-11)25-2)22-19(23)16-9-8-15(26-16)12-4-3-5-13(20)18(12)21/h3-10H,1-2H3,(H,22,23)
  • InChiKey: YLBJBTKMNWRJLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2,3-dichlorophenyl)-N-(2,4-dimethoxyphenyl)-2-furancarboxamide
  • 5-(2,3-dichlorophenyl)-N-(2,4-dimethoxyphenyl)-2-furamide
  • AP-970/41128482
  • ZINC01158124
  • STK141774

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.004
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0007 0.0007
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0157 1
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1292 0.3013 0.3018
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.004
Brugia malayi Muscleblind-like protein 0.0145 0.0322 0.0322
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0024 0.0039 0.2495
Onchocerca volvulus 0.0025 0.004 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.004 0.2552
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0007 0.0443
Brugia malayi Inositol-1 0.0075 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.004 0.2552
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.2552
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0039 0.013
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0157 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0322 0.0323
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0025 0.1824
Chlamydia trachomatis DNA topoisomerase I 0.0011 0.0007 0.2749
Schistosoma mansoni hypothetical protein 0.0178 0.0399 0.0399
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0157 1
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.004 0.289
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0138 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.1652
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0157 0.052
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.004 0.2552
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.4263 0.9985 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.2552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) brahma associated protein 0.0011 0.0007 0.0007
Schistosoma mansoni protein kinase 0.427 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0157 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0157 0.052
Schistosoma mansoni brg-1 associated factor 0.0011 0.0007 0.0007
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0157 0.0157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.1652
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.004 0.289
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0039 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0039 0.013
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.2552
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.427 1 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.004
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1292 0.3013 1
Schistosoma mansoni protein kinase 0.427 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0157 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0322 0.0322
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0007 0.0443
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.004 0.2552
Giardia lamblia Hypothetical protein 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1286 0.2998 0.3003
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0443
Echinococcus granulosus muscleblind protein 0.0145 0.0322 0.0322
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0322 0.0323
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0007 0.0007
Schistosoma mansoni inositol monophosphatase 0.0075 0.0157 0.0157
Brugia malayi hypothetical protein 0.0024 0.0039 0.0039
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0157 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0157 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.2552
Brugia malayi hypothetical protein 0.0016 0.0019 0.0019
Echinococcus granulosus geminin 0.0178 0.0399 0.0399
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Chlamydia trachomatis SWIB complex protein 0.0011 0.0007 0.2749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0025 0.569
Loa Loa (eye worm) inositol-1 0.0075 0.0157 0.0157
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0007 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.004 0.2552
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0025 0.1611
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.004 0.2552
Echinococcus multilocularis muscleblind protein 0.0145 0.0322 0.0322
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0039 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0178 0.0399 0.0399
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0157 1
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0007 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0039 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.004 0.2552
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0025 0.569
Schistosoma mansoni inositol monophosphatase 0.0075 0.0157 0.0157
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0157 0.0157
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0157 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0039 0.2495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.1652
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.004 0.2552
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0138 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.427 1 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.004 0.289
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.1652
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1292 0.3013 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.004 0.2552
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.004 0.2552
Onchocerca volvulus 0.0011 0.0007 0.1735
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.004 0.289
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0039 0.2495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0039
Echinococcus multilocularis geminin 0.0178 0.0399 0.0399

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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