Detailed information for compound 675751

Basic information

Technical information
  • TDR Targets ID: 675751
  • Name: N-[2-(3-chloro-4-methoxyphenyl)-1,3-benzoxazo l-5-yl]-2-methylbenzamide
  • MW: 392.835 | Formula: C22H17ClN2O3
  • H donors: 1 H acceptors: 2 LogP: 5.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)c1oc2c(n1)cc(cc2)NC(=O)c1ccccc1C
  • InChi: 1S/C22H17ClN2O3/c1-13-5-3-4-6-16(13)21(26)24-15-8-10-20-18(12-15)25-22(28-20)14-7-9-19(27-2)17(23)11-14/h3-12H,1-2H3,(H,24,26)
  • InChiKey: KHBQMRJHXNOWPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3-chloro-4-methoxy-phenyl)-1,3-benzoxazol-5-yl]-2-methyl-benzamide
  • STK089294
  • Oprea1_470349
  • Oprea1_106654
  • ZINC01158047

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0038 0.2546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.015 0.0498
Schistosoma mansoni inositol monophosphatase 0.0076 0.015 0.015
Brugia malayi Muscleblind-like protein 0.0148 0.0309 0.0309
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Chlamydia trachomatis DNA topoisomerase I 0.0011 0.0007 0.276
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Echinococcus multilocularis geminin 0.0181 0.0381 0.0381
Brugia malayi hypothetical protein 0.0016 0.0018 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0038 0.2501
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.015 0.5
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0007 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.015 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0024 0.5654
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0024 0.1607
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0038 0.2546
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0038 0.0038
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0038 0.2546
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.015 1
Schistosoma mansoni hypothetical protein 0.0181 0.0381 0.0381
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0125
Echinococcus multilocularis muscleblind protein 0.0148 0.0309 0.0309
Mycobacterium ulcerans hypothetical protein 0.0025 0.0038 0.2546
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0038 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0007 0.0444
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.4541 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0133 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0125
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.1648
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0038 0.2546
Loa Loa (eye worm) inositol-1 0.0076 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.015 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.015 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0024 0.5654
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0007
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1374 0.3014 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.1648
Echinococcus granulosus geminin 0.0181 0.0381 0.0381
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0038 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0038 0.2546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0038 0.2884
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0038 0.2546
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0025 0.0038 0.2501
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0309 0.0309
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0038 0.2546
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1374 0.3014 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.015 1
Schistosoma mansoni brg-1 associated factor 0.0011 0.0007 0.0007
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.015 0.0498
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0038 0.2546
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Brugia malayi hypothetical protein 0.0025 0.0038 0.0038
Schistosoma mansoni inositol monophosphatase 0.0076 0.015 0.015
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0038 0.2884
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0038 0.2546
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0024 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.015 1
Schistosoma mansoni hypothetical protein 0.0181 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0148 0.0309 0.0309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0024 0.182
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0038 0.2546
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.4534 0.9985 1
Brugia malayi Inositol-1 0.0076 0.015 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.1648
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0038 0.0038
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0133 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0444
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0038 0.2501
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0038 0.2546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.1648
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.015 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.015 1
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.015 0.015
Onchocerca volvulus 0.0011 0.0007 0.1742
Schistosoma mansoni protein kinase 0.4541 1 1
Loa Loa (eye worm) brahma associated protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0038 0.2546
Schistosoma mansoni protein kinase 0.4541 1 1
Onchocerca volvulus 0.0025 0.0038 1
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1374 0.3014 0.3018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0038 0.2884
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.4541 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0038 0.2884
Loa Loa (eye worm) hypothetical protein 0.1367 0.2999 0.3003
Loa Loa (eye worm) hypothetical protein 0.0148 0.0309 0.0309
Chlamydia trachomatis SWIB complex protein 0.0011 0.0007 0.276
Giardia lamblia Hypothetical protein 0.0008 0 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0038 0.2546
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0007 0.0444
Echinococcus granulosus muscleblind protein 0.0148 0.0309 0.0309
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.015 0.015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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