Detailed information for compound 678814

Basic information

Technical information
  • TDR Targets ID: 678814
  • Name: ZINC01147489
  • MW: 466.549 | Formula: C25H26N2O5S
  • H donors: 1 H acceptors: 4 LogP: 4.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(c(c1)NC(=O)CN(S(=O)(=O)c1ccccc1)c1ccc(c(c1)C)C)C
  • InChi: 1S/C25H26N2O5S/c1-17-11-13-21(14-19(17)3)27(33(30,31)22-8-6-5-7-9-22)16-24(28)26-23-15-20(25(29)32-4)12-10-18(23)2/h5-15H,16H2,1-4H3,(H,26,28)
  • InChiKey: AXZSJHMUJXRINY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0108 0.0276
Trypanosoma brucei oxidoreductase-like protein 0.0151 0.0637 1
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0054 0.0709
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0012 0.006
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.0542
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0151 0.0637 0.3252
Schistosoma mansoni hypothetical protein 0.0184 0.0786 0.4005
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.2229 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0054 0.0709
Schistosoma mansoni coup transcription factor 0.0022 0.0054 0.0263
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0054 0.0263
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0128 0.0108
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0151 0.0637 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0054 0.0709
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.0542
Loa Loa (eye worm) hypothetical protein 0.0151 0.0637 0.8748
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0054 0.0709
Loa Loa (eye worm) DR-78 0.001 0.0002 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0031 0.008
Plasmodium falciparum enoyl-acyl carrier reductase 0.2229 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0054 0.0739
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0054 0.0275
Loa Loa (eye worm) hypothetical protein 0.0034 0.0108 0.1489
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0151 0.0637 1
Echinococcus granulosus cpg binding protein 0.0033 0.0105 0.0537
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0255 0.129
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0031 0.0148
Schistosoma mansoni alpha-glucosidase 0.0147 0.062 0.316
Brugia malayi hypothetical protein 0.0011 0.0008 0.0076
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0266 0.364
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0012
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0002 0.0033
Onchocerca volvulus 0.0151 0.0637 1
Onchocerca volvulus 0.0022 0.0054 0.081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0109
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0151 0.0637 0.0607
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0128 0.0108
Loa Loa (eye worm) oxidoreductase 0.0151 0.0637 0.8748
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0128 0.0108
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0151 0.0637 0.0607
Echinococcus multilocularis cpg binding protein 0.0033 0.0105 0.0268
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0054 0.081
Schistosoma mansoni cpg binding protein 0.0031 0.0097 0.0484
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0128 0.1742
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0054 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0054 0.0739
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0151 0.0637 0.0607
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0157 0.0664 0.9119
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0073 0.0285 0.1443
Loa Loa (eye worm) retinol dehydrogenase 12 0.0151 0.0637 0.8748
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0054 0.0709
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0128 0.0325
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0179
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0151 0.0637 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0054 0.0275
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0054 0.0263
Schistosoma mansoni cpg binding protein 0.0033 0.0105 0.0525
Brugia malayi hypothetical protein 0.0018 0.0036 0.0465
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0108 0.0276
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0054 0.0137
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0128 0.0652
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0128 0.1754
Mycobacterium tuberculosis Probable oxidoreductase 0.0151 0.0637 0.0607
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0128 0.1742
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0054 0.0709
Schistosoma mansoni dihydropteridine reductase 0.0151 0.0637 0.3244
Echinococcus granulosus geminin 0.0184 0.0786 0.4013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0128 0.0108
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.2229 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0128 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0002 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0012
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0151 0.0637 0.0607
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.008
Schistosoma mansoni alpha-glucosidase 0.0147 0.062 0.316
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0054 0.081
Onchocerca volvulus 0.0151 0.0637 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0266 0.3661
Echinococcus granulosus tar DNA binding protein 0.0069 0.0266 0.1361
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0223 0.0192
Leishmania major hypothetical protein, conserved 0.0027 0.008 0.0967
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0266 0.135
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Echinococcus granulosus GPCR family 2 0.0034 0.0108 0.0554
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0031 0.0179
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0054 0.0263
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0109
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.008 0.0967
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0151 0.0637 0.0607
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Echinococcus multilocularis muscleblind protein 0.0157 0.0664 0.1691
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0008 0.0028
Trichomonas vaginalis hypothetical protein 0.2229 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.2229 1 1
Brugia malayi hypothetical protein 0.0027 0.008 0.1068
Brugia malayi ecdysteroid receptor 0.0022 0.0054 0.0709
Brugia malayi nuclear hormone receptor 0.0022 0.0054 0.0709
Trypanosoma brucei pteridine reductase 1 0.0151 0.0637 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0266 0.0679
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0076
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.008 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0108 0.0554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0108 0.0554
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0054 0.0275
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0054 0.0709
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0054 0.0275
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0728 0.1855
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0054 0.0709
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0128 0.1742
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0109
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0151 0.0637 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0108 0.0276
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0054 0.0137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0097 0.1333
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0151 0.0637 0.0607
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0266 0.135
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0054 0.0137
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0151 0.0637 0.3244
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0054 0.0709
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0008 0.0028
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0128 0.1727
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0108 0.1461
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0664 0.1691
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0108 0.1461
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0054 0.0275
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0151 0.0637 0.1622
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0054 0.0709
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.008 0.0967
Schistosoma mansoni cpg binding protein 0.0033 0.0105 0.0525
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0031 0.043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.088 0.3924 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0054 0.0263
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0151 0.0637 0.8748
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0285 0.389
Mycobacterium tuberculosis Possible oxidoreductase 0.0151 0.0637 0.0607
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0151 0.0637 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0436 0.5983
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.002 0.0281
Brugia malayi nuclear receptor NHR-88 0.0022 0.0054 0.0709
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0054 0.0709
Loa Loa (eye worm) hypothetical protein 0.0073 0.0285 0.391
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.0542
Brugia malayi hypothetical protein 0.0011 0.0008 0.0076
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0054 0.0275
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0054 0.0263
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0054 0.0275
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0109
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0054 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0054 0.0739
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.002 0.0246
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0002 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0006
Brugia malayi RNA binding protein 0.0069 0.0266 0.364
Loa Loa (eye worm) RNA binding protein 0.0069 0.0266 0.3661
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0054 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0054 0.0739
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0151 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0054 0.0275
Plasmodium vivax enoyl-acyl carrier protein reductase 0.2229 1 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0054 0.0263
Brugia malayi nuclear receptor RXR 0.0011 0.0008 0.0076
Echinococcus granulosus muscleblind protein 0.0157 0.0664 0.339
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0048
Schistosoma mansoni alpha glucosidase 0.0038 0.0128 0.064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0108 0.1489
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0128 0.0108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0054 0.0739
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0151 0.0637 0.0607
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0054 0.081
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.1958 0.4989
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0054 0.0263
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0266 0.135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0031 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0054 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0128 0.0108
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0151 0.0637 1
Brugia malayi Muscleblind-like protein 0.0157 0.0664 0.9116
Onchocerca volvulus 0.0099 0.0403 0.6309
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.008 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0054 0.0709
Leishmania major oxidoreductase-like protein 0.0151 0.0637 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0054 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0436 0.5997
Schistosoma mansoni hypothetical protein 0.0444 0.1958 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0151 0.0637 0.0607
Schistosoma mansoni hypothetical protein 0.0184 0.0786 0.4005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0054 0.0739
Brugia malayi isocitrate dehydrogenase 0.0017 0.0031 0.0398
Onchocerca volvulus 0.0031 0.0097 0.1492
Trypanosoma brucei glucosidase, putative 0.0038 0.0128 0.1742
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0728 0.1855
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.0542
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0006
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0728 0.3717
Brugia malayi CXXC zinc finger family protein 0.0031 0.0097 0.1305
Leishmania major pteridine reductase 1 0.0151 0.0637 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0054 0.0739
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0157 0.0664 0.9119
Loa Loa (eye worm) hypothetical protein 0.0106 0.0436 0.5997
Brugia malayi TAR-binding protein 0.0069 0.0266 0.364
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0054 0.0709
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.1097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0128 0.1742
Brugia malayi steroid hormone receptor 0.0022 0.0054 0.0709
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.008 0.0049
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0128 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0054 0.0709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0054 0.0739
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.008 0.0049
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0031 0.0398
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0728 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0436 0.5983
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0151 0.0637 0.0607
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0151 0.0637 0.8744
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0128 0.1742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0054 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0054 0.0709
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0266 0.3661
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0266 0.135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0054 0.0137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0054 0.0263
Echinococcus granulosus dnaJ subfamily B 0.0444 0.1958 1
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0151 0.0637 0.0607
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.2229 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0266 0.135
Echinococcus multilocularis geminin 0.0184 0.0786 0.2002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0031 0.008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0728 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0008 0.0109
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0031 0.0179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0054 0.0263
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0151 0.0637 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0128 0.0108
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0054 0.0275
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0151 0.0637 0.8744
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0128 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0739
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0151 0.0637 0.0607
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0054 0.0709
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0054 0.0137
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0054 0.0137
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.2229 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0151 0.0637 0.0607

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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