Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0171 | 0.5532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2334 | 0.2334 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.4454 | 0.8051 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0171 | 0.5532 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0171 | 0.5532 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.121 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.121 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0171 | 0.5532 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0171 | 0.5532 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.4454 | 0.8051 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | beta galactosidase | 0.0093 | 0.2334 | 0.4219 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4454 | 0.4454 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | beta-galactosidase | 0.0093 | 0.2334 | 0.4219 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0171 | 0.5532 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.121 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0171 | 0.5532 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.4454 | 0.8051 |
Echinococcus granulosus | dihydrofolate reductase | 0.0171 | 0.5532 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.7899 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0065 | 0.121 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0093 | 0.2334 | 0.4219 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.4454 | 0.4454 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0171 | 0.5532 | 0.7004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.4454 | 0.8051 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0065 | 0.121 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0171 | 0.5532 | 0.5532 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.