Detailed information for compound 687417

Basic information

Technical information
  • TDR Targets ID: 687417
  • Name: 1-(3-ethyl-6-phenyl-7-propanoyl-[1,2,4]triazo lo[3,4-b][1,3,4]thiadiazin-5-yl)propan-1-one
  • MW: 356.442 | Formula: C18H20N4O2S
  • H donors: 0 H acceptors: 4 LogP: 4.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)c1sc2nnc(n2n(c1c1ccccc1)C(=O)CC)CC
  • InChi: 1S/C18H20N4O2S/c1-4-13(23)17-16(12-10-8-7-9-11-12)22(15(24)6-3)21-14(5-2)19-20-18(21)25-17/h7-11H,4-6H2,1-3H3
  • InChiKey: SHXTZNGSTZCPAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-ethyl-7-(1-oxopropyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl]propan-1-one
  • 1-(3-ethyl-6-phenyl-7-propionyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5-yl)propan-1-one
  • ZINC04518276

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0299 0.1126
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0364 0.5061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Schistosoma mansoni sugar transporter 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.0667 0.1011
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0421 0.7414
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0421 0.5975
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.057 0.0863
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.0667 0.0509
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0569 0.2373
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0421 0.5975
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0364 1
Toxoplasma gondii sugar transporter ST2 0.003 0.0167 0.0252
Schistosoma mansoni sugar transporter 0.003 0.0167 0.0519
Leishmania major hypothetical protein, conserved 0.003 0.0167 0.1836
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0421 0.1688
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0573 0.8454
Brugia malayi hypothetical protein 0.003 0.0167 0.0401
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0351 0.3706 0.5613
Onchocerca volvulus 0.003 0.0167 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0569 0.1832
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0573 0.8454
Trypanosoma brucei glucose transporter 1E 0.0067 0.0573 0.8454
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0421 0.1304
Giardia lamblia Sugar-proton symporter 0.003 0.0167 0.2278
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Plasmodium falciparum protein kinase 7 0.0613 0.6602 0.6583
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0351 0.3706 0.3599
Leishmania major glucose transporter, lmgt1 0.0067 0.0573 0.8454
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0667 1
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0573 0.8454
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0167 0.0401
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0364 0.143
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0364 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0421 0.5975
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0364 0.5061
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0421 0.5975
Onchocerca volvulus 0.003 0.0167 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.0421 0.1304
Onchocerca volvulus 0.003 0.0167 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0217 0.2225 0.337
Trypanosoma cruzi hexose transporter, putative 0.003 0.0167 0.1836
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0421 0.7414
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0125 0.0252
Brugia malayi hypothetical protein 0.003 0.0167 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0167 0.0113
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0421 0.5975
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.0401
Loa Loa (eye worm) hypothetical protein 0.0049 0.0369 0.112
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.057 0.041
Brugia malayi Sugar transporter family protein 0.003 0.0167 0.0401
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0236 0.2965
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0573 0.8454
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0573 0.2389
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0421 0.1304
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0167 0.0519
Brugia malayi major facilitator superfamily protein 0.003 0.0167 0.0401
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0421 0.1688
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0167 0.0519
Echinococcus granulosus General substrate transporter 0.0186 0.1888 0.8449
Trypanosoma cruzi glucose transporter, putative 0.003 0.0167 0.1836
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0569 0.2373
Loa Loa (eye worm) sugar transporter 0.003 0.0167 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Echinococcus multilocularis General substrate transporter 0.0186 0.1888 0.8449
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0421 0.1688
Onchocerca volvulus 0.003 0.0167 1
Trypanosoma cruzi hexose transporter 0.0067 0.0573 0.8454
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Mycobacterium ulcerans sugar transporter 0.003 0.0167 0.2954
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0518 0.2137
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.057 0.041
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0573 0.2389
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.057 0.0518
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0573 0.2389
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.0519
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.057 0.041
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0364 0.143
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.057 0.0518
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.0401
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0364 0.1104
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0364 0.5061
Onchocerca volvulus 0.003 0.0167 1
Giardia lamblia Hexose transporter 0.003 0.0167 0.2278
Trypanosoma cruzi sugar transporter, putative 0.003 0.0167 0.1836
Loa Loa (eye worm) hypothetical protein 0.0053 0.0414 0.1279
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.0519
Plasmodium falciparum mitogen-activated protein kinase 2 0.0351 0.3706 0.3671
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0519
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Schistosoma mansoni hypothetical protein 0.0217 0.2225 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0548 0.9599
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0421 0.5975
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0167 0.0519
Onchocerca volvulus 0.003 0.0167 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0667 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0921 1 1
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0167 0.2954
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Schistosoma mansoni protein kinase 0.0067 0.0569 0.2373
Brugia malayi Sugar transporter family protein 0.0217 0.2225 0.7722
Onchocerca volvulus 0.003 0.0167 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Leishmania major glucose transporter, lmgt2 0.0067 0.0573 0.8454
Entamoeba histolytica protein kinase, putative 0.0067 0.0569 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.057 0.0863
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0167 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0667 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0421 0.0637
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0167 0.0401
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.0519
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0548 0.1759
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.057 0.0518
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0421 0.7117
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0667 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0569 0.1832
Loa Loa (eye worm) hypothetical protein 0.0065 0.0548 0.1759
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0569 0.2373
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0548 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Brugia malayi Cyclin, N-terminal domain containing protein 0.0275 0.2865 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0548 0.2277
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0167 0.2954
Schistosoma mansoni glucose transporter 0.003 0.0167 0.0519
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0548 0.2277
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0421 0.7117
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0167 0.0401
Schistosoma mansoni sugar transporter 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Plasmodium falciparum hexose transporter 0.0217 0.2225 0.2182
Loa Loa (eye worm) sugar transporter 0.0217 0.2225 0.7722
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0084 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0421 0.1688
Trypanosoma brucei glucose transporter 2A 0.0067 0.0573 0.8454
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0364 0.143
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0573 0.2389
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0548 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0364 0.3046
Schistosoma mansoni glucose transport protein 0.0217 0.2225 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0421 0.1304
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0573 0.8454
Brugia malayi hypothetical protein 0.003 0.0167 0.0401
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Plasmodium falciparum protein kinase 5 0.0053 0.0421 0.0369
Entamoeba histolytica protein kinase, putative 0.0067 0.0569 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Loa Loa (eye worm) hypothetical protein 0.0048 0.0364 0.1104
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.0519
Trichomonas vaginalis glucose transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0364 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0421 0.1688
Leishmania major protein kinase, putative 0.0067 0.0569 0.8396
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0217 0.2225 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Onchocerca volvulus 0.003 0.0167 1
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0573 0.2389
Toxoplasma gondii protein kinase, putative 0.0613 0.6602 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0275 0.2865 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0569 0.1832
Schistosoma mansoni protein kinase 0.0067 0.0569 0.2373
Schistosoma mansoni sugar transporter 0.003 0.0167 0.0519
Schistosoma mansoni glucose transport protein 0.0217 0.2225 1
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.2225 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.057 0.0518
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0167 0.0519
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0667 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0421 0.1688
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Onchocerca volvulus 0.003 0.0167 1
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.0519
Brugia malayi Cam kinase protein 1 0.0067 0.0569 0.1832
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0548 0.2277
Plasmodium vivax hexose transporter 0.0217 0.2225 0.2093
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0364 0.0552
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0569 0.8396
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0573 0.8454
Schistosoma mansoni glucose transport protein 0.0217 0.2225 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0548 0.2277
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Onchocerca volvulus Putative transporter 0.003 0.0167 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0364 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.0519
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0364 0.143
Echinococcus multilocularis solute carrier family 22 0.003 0.0167 0.0519
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0167 0.0519
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0548 0.1759
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.057 0.0518
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0364 0.143
Echinococcus granulosus solute carrier family 22 0.003 0.0167 0.0519
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.057 0.0863
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0284 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0421 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0519
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0167 0.1836
Loa Loa (eye worm) hypothetical protein 0.0065 0.0548 0.1759
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0421 0.1688
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0421 0.5975
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0573 0.2389
Brugia malayi major facilitator superfamily protein 0.003 0.0167 0.0401
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0548 0.2277
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Plasmodium vivax protein kinase Crk2 0.0053 0.0421 0.0258
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0518 0.2137
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2225 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.057 0.041
Toxoplasma gondii sugar transporter ST3 0.003 0.0167 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0573 0.2389
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0421 0.1688
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0519
Entamoeba histolytica hypothetical protein 0.0048 0.0364 0.6027
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0364 0.6279
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0573 0.8454
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0167 0.0252
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0364 1
Brugia malayi cell division control protein 2 homolog 0.0053 0.0421 0.1304
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0421 0.5975
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Brugia malayi Sugar transporter family protein 0.003 0.0167 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0519
Schistosoma mansoni protein kinase 0.0067 0.0569 0.2373
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0167 0.2954
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0569 0.2373
Toxoplasma gondii sugar transporter ST1 0.003 0.0167 0.0252
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0167 0.0519
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0167 0.1836
Plasmodium falciparum proline--tRNA ligase 0.0076 0.0667 0.0617
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0421 0.1688
Trypanosoma brucei sugar transporter, putative 0.003 0.0167 0.1836
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0421 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0167 0.0519
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0421 0.1688
Loa Loa (eye worm) hypothetical protein 0.0067 0.0569 0.1832
Leishmania major glucose transporter, lmgt3 0.0067 0.0573 0.8454
Onchocerca volvulus 0.003 0.0167 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Onchocerca volvulus 0.003 0.0167 1
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0421 0.1688
Trypanosoma brucei glucose transporter, putative 0.0067 0.0573 0.8454
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0401
Trichomonas vaginalis sugar transporter, putative 0.003 0.0167 0.0519

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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