Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0491 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0491 | 1 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
36Cl- uptake (functional) | = 0.34 | In vitro [36Cl]-uptake in rat cerebrocortical synaptoneurosomes | ChEMBL. | 8568803 |
ED50 (functional) | > 50 mg kg-1 | Antagonistic activity of the compound against metrazole-induced clonic convulsions in rat after ip injection | ChEMBL. | 8568803 |
Ki (binding) | = 3.1 nM | Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes | ChEMBL. | 8568803 |
Ki (binding) | = 3.1 nM | Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes | ChEMBL. | 8568803 |
[35S] TBPS shift (binding) | = 0.97 | In vitro inhibition of [35S]-TBPS binding in rat brain membranes, activity expressed as [35S]-TBPS shift value | ChEMBL. | 8568803 |
[35S] TBPS shift (binding) | = 0.97 | In vitro inhibition of [35S]-TBPS binding in rat brain membranes, activity expressed as [35S]-TBPS shift value | ChEMBL. | 8568803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.