TDR Targets

Basic information

Technical information

TDR Targets ID: 701911
Name: N-(5-chloro-2-methoxyphenyl)-1-[(4-methylphen yl)methyl]-6-oxopyridine-3-carboxamide
MW: 382.84 | Formula: C21H19ClN2O3
H donors: 1 H acceptors: 2 LogP: 3.4 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)c1ccc(=O)n(c1)Cc1ccc(cc1)C)Cl
InChi: 1S/C21H19ClN2O3/c1-14-3-5-15(6-4-14)12-24-13-16(7-10-20(24)25)21(26)23-18-11-17(22)8-9-19(18)27-2/h3-11,13H,12H2,1-2H3,(H,23,26)
InChiKey: HUVNRXGZKININE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(5-chloro-2-methoxy-phenyl)-1-[(4-methylphenyl)methyl]-6-oxo-pyridine-3-carboxamide
N-(5-chloro-2-methoxyphenyl)-1-[(4-methylphenyl)methyl]-6-oxo-3-pyridinecarboxamide
N-(5-chloro-2-methoxy-phenyl)-6-keto-1-(4-methylbenzyl)nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0066	0.0885	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1808	0.339
Echinococcus multilocularis	lamin	0.0028	0.0049	0.0049
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Onchocerca volvulus		0.0028	0.0049	0.0092
Schistosoma mansoni	hypothetical protein	0.0034	0.0184	0.066
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0267	0.5334	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0037	0.007
Onchocerca volvulus	Glucosylceramidase homolog	0.0175	0.3305	0.6225
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0043	0.0374	0.0374
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Schistosoma mansoni	lamin	0.0028	0.0049	0.0175
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0096	0.1564	0.1564
Brugia malayi	Carboxylesterase family protein	0.0152	0.2791	0.5233
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0096	0.1564	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0043	0.0374	0.0701
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	carboxylesterase	0.0152	0.2791	0.5233
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0066	0.0885	0.1659
Mycobacterium ulcerans	putative regulatory protein	0.0031	0.0112	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0173	0.062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0184	0.0345
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0152	0.2791	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0043	0.0374	0.0701
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Echinococcus granulosus	lamin	0.0028	0.0049	0.0049
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0184	0.0184
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0031	0.0112	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.1808	0.339
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Schistosoma mansoni	hypothetical protein	0.0034	0.0184	0.066
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0096	0.1564	0.1564
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0096	0.1564	0.5604
Loa Loa (eye worm)	acetylcholinesterase 1	0.0152	0.2791	0.5233
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0112	0.0209
Mycobacterium leprae	conserved hypothetical protein	0.0031	0.0112	0.5
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0267	0.5334	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0031	0.0112	1
Echinococcus multilocularis	musashi	0.0028	0.0049	0.0049
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0096	0.1564	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1057	0.1981
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0043	0.0374	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0324
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0173	0.062
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0112	0.0209
Echinococcus multilocularis	acetylcholinesterase	0.0152	0.2791	0.2791
Echinococcus granulosus	intermediate filament protein	0.0028	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0073	0.1057	0.3785
Brugia malayi	Carboxylesterase family protein	0.0152	0.2791	0.5233
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.1564	0.2933
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Plasmodium vivax	SET domain protein, putative	0.0033	0.0173	1
Onchocerca volvulus		0.0033	0.0173	0.0326
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0173	0.0515
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Echinococcus multilocularis	carboxylesterase 5A	0.0152	0.2791	0.2791
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0173	0.062
Echinococcus granulosus	acetylcholinesterase	0.0152	0.2791	0.2791
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.4595	0.8615
Schistosoma mansoni	hypothetical protein	0.0034	0.0184	0.066
Echinococcus granulosus	acetylcholinesterase	0.0152	0.2791	0.2791
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0184	0.0184
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0173	0.0173
Echinococcus multilocularis	neuropeptide receptor A26	0.0478	1	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0173	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2791	0.5233
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0184	0.0184
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0173	0.0173
Echinococcus granulosus	GPCR family 2	0.0034	0.0184	0.0184
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0049	0.0175
Schistosoma mansoni	hypothetical protein	0.0034	0.0184	0.066
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.1808	0.339
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Toxoplasma gondii	hypothetical protein	0.0085	0.1302	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0049	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0374	0.0701
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.1302	0.2441
Brugia malayi	Pre-SET motif family protein	0.0233	0.4595	0.8615
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0049	0.0091
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.5334	1
Echinococcus multilocularis	neuropeptide s receptor	0.0478	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.1302	0.2441
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0096	0.1564	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.1808	0.339
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0043	0.0374	0.0701
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0096	0.1564	1
Onchocerca volvulus		0.0028	0.0049	0.0092
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Echinococcus granulosus	lamin dm0	0.0028	0.0049	0.0049
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0096	0.1564	0.2933
Plasmodium falciparum	GAF domain-related protein, putative	0.0031	0.0112	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0184	0.0184
Echinococcus granulosus	carboxylesterase 5A	0.0152	0.2791	0.2791
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0049	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1057	0.1981
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0049	0.0091
Schistosoma mansoni	lamin	0.0028	0.0049	0.0175
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0184	0.0345
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0043	0.0374	0.0701
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0173	0.0173
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.3305	0.6195
Brugia malayi	intermediate filament protein	0.0028	0.0049	0.0091
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2791	0.5233
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.1302	0.2441
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0184	0.0184
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0146	0.0146
Echinococcus multilocularis	lamin dm0	0.0028	0.0049	0.0049
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0096	0.1564	0.2933
Trichomonas vaginalis	set domain proteins, putative	0.0266	0.5308	0.9952
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0043	0.0374	0.0374
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0096	0.1564	0.2933
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0096	0.1564	1
Onchocerca volvulus		0.0266	0.5308	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0031	0.0112	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0173	0.062
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3513	0.6586
Echinococcus granulosus	neuropeptide receptor A26	0.0478	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0184	0.0345
Mycobacterium ulcerans	putative regulatory protein	0.0031	0.0112	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0184	0.0345
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.3513	0.6586
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0043	0.0374	0.1339
Echinococcus multilocularis	acetylcholinesterase	0.0152	0.2791	0.2791

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 701911