Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor A26 | 0.0487 | 0.5157 | 1 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0375 | 0.3846 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0258 | 0.2482 | 0.4813 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0487 | 0.5157 | 0.5157 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0084 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1571 | 1 |
Echinococcus multilocularis | geminin | 0.018 | 0.1571 | 0.1571 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.2482 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0107 | 0.0716 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0716 | 0.4558 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0151 | 0.1228 | 0.782 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.0375 | 0.3846 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0107 | 0.0716 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0107 | 0.0716 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.0716 | 0.1388 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0151 | 0.1228 | 0.2382 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.0716 | 0.2884 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0107 | 0.0716 | 0.5 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0185 | 0.1628 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0151 | 0.1228 | 0.1228 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.0716 | 0.0716 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0107 | 0.0716 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0487 | 0.5157 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0151 | 0.1228 | 0.4948 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0151 | 0.1228 | 0.1228 |
Trypanosoma brucei | protein kinase, putative | 0.0107 | 0.0716 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.0716 | 0.2884 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.0716 | 0.1388 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0487 | 0.5157 | 0.5157 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0107 | 0.0716 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0107 | 0.0716 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0151 | 0.1228 | 0.782 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0046 | 0.0011 | 0.0011 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0107 | 0.0716 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0151 | 0.1228 | 0.2382 |
Onchocerca volvulus | 0.0053 | 0.0084 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0107 | 0.0716 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0107 | 0.0716 | 1 |
Brugia malayi | hypothetical protein | 0.0258 | 0.2482 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0107 | 0.0716 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0151 | 0.1228 | 0.782 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0148 | 0.1193 | 0.2525 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0258 | 0.2482 | 0.2482 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0084 | 0.0535 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0151 | 0.1228 | 0.4948 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.0716 | 0.0716 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0084 | 0.0535 |
Echinococcus granulosus | geminin | 0.018 | 0.1571 | 0.3045 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0148 | 0.1193 | 0.2525 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1571 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0107 | 0.0716 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0046 | 0.0011 | 0.0022 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0107 | 0.0716 | 1 |
Trypanosoma brucei | beta lactamase | 0.0071 | 0.0297 | 0.4145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.