Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0151 | 0.4803 | 0.4803 |
Leishmania major | carbonic anhydrase-like protein | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1412 | 0.1412 |
Echinococcus granulosus | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4803 | 0.4803 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2924 | 0.2924 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.4803 | 0.4775 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0253 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1412 | 0.1412 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0253 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0253 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.2924 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0151 | 0.4803 | 0.4775 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3043 | 0.3043 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2924 | 0.2924 |
Echinococcus granulosus | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Schistosoma mansoni | carbonic anhydrase | 0.0151 | 0.4803 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.2924 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3043 | 0.3043 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0151 | 0.4803 | 0.4775 |
Echinococcus granulosus | carbonic anhydrase II | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.2924 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.2924 | 0.2886 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0151 | 0.4803 | 0.2655 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4803 | 0.4803 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2924 | 0.2924 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Plasmodium falciparum | carbonic anhydrase | 0.0151 | 0.4803 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1512 | 0.1512 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3043 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1412 | 0.1412 |
Echinococcus multilocularis | carbonic anhydrase | 0.0151 | 0.4803 | 0.2655 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0151 | 0.4803 | 0.4775 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1412 | 0.1412 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0253 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0151 | 0.4803 | 0.2655 |
Toxoplasma gondii | hypothetical protein | 0.0151 | 0.4803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4803 | 0.4803 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1412 | 0.1412 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 uM | Tested for inhibitory concentration against human Endothelin-converting enzyme 1 at 10 microM | ChEMBL. | 12067547 |
IC50 (binding) | = 0.15 uM | Tested for inhibitory concentration against human Endothelin-converting enzyme 1 at 10 microM | ChEMBL. | 12067547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.