TDR Targets

Basic information

Technical information

TDR Targets ID: 714547
Name: 3-methyl-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)me thyl]benzamide
MW: 293.32 | Formula: C17H15N3O2
H donors: 1 H acceptors: 3 LogP: 2.97 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)C(=O)NCc1onc(n1)c1ccccc1
InChi: 1S/C17H15N3O2/c1-12-6-5-9-14(10-12)17(21)18-11-15-19-16(20-22-15)13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H,18,21)
InChiKey: NTYZAFDUIKTKHL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

ZINC04843340
STK233289

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0779	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0035	0.0035
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Plasmodium vivax	glutathione reductase, putative	0.0099	0.0873	0.2102
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0252	0.2924	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0035	0.0035
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.0874	0.0842
Plasmodium falciparum	glutathione reductase	0.0099	0.0873	0.2102
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0242	0.0208
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0434	0.0434
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0344	0.4151	0.4151
Mycobacterium tuberculosis	Probable oxidoreductase	0.0252	0.2924	0.7043
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0874	0.0874
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0424	0.5226	0.5226
Loa Loa (eye worm)	glutathione reductase	0.0099	0.0873	0.0841
Trypanosoma cruzi	hypothetical protein, conserved	0.0224	0.2548	0.2548
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0201	0.2233	0.5379
Brugia malayi	jmjC domain containing protein	0.0037	0.0035	0.0035
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0344	0.4151	0.3591
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0	0.5
Schistosoma mansoni	jumonji domain containing protein	0.008	0.0606	0.0606
Schistosoma mansoni	chromatin regulatory protein sir2	0.0779	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0434	0.04
Giardia lamblia	Sirtuin type 2	0.0201	0.2233	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0424	0.5226	0.5209
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0344	0.4151	0.4151
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0227	0.2584	0.6224
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.01	0.0883	0.0883
Schistosoma mansoni	chromatin regulatory protein sir2	0.0779	1	1
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0344	0.4151	0.4151
Brugia malayi	TAR-binding protein	0.0067	0.0434	0.0434
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0424	0.5226	0.5226
Loa Loa (eye worm)	transcriptional regulator	0.0201	0.2233	0.2206
Leishmania major	trypanothione reductase	0.0099	0.0873	0.0873
Schistosoma mansoni	chromatin regulatory protein sir2	0.0201	0.2233	0.2233
Schistosoma mansoni	chromatin regulatory protein sir2	0.0201	0.2233	0.2233
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0779	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0779	1	1
Loa Loa (eye worm)	sirtuin 4	0.0201	0.2233	0.2206
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0344	0.4151	1
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0424	0.5226	0.5226
Brugia malayi	RNA binding protein	0.0067	0.0434	0.0434
Toxoplasma gondii	histone deacetylase SIR2-like	0.0201	0.2233	0.5379
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0344	0.4151	1
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0344	0.4151	0.4151
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0779	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.01	0.0883	0.0883
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0386	0.0352
Leishmania major	hypothetical protein, conserved	0.0224	0.2548	0.2548
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0201	0.2233	0.5379
Mycobacterium tuberculosis	Probable reductase	0.0227	0.2584	0.6224
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0252	0.2924	0.7043
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0201	0.2233	0.2233
Schistosoma mansoni	kinase	0.0051	0.0217	0.0217
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0344	0.4151	0.4151
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0227	0.2584	0.6224
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0434	0.04
Brugia malayi	glutathione reductase	0.0099	0.0873	0.0873
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0344	0.4151	0.4151
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0434	0.0434
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0201	0.2233	0.2233
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.0874	0.0874
Schistosoma mansoni	chromatin regulatory protein sir2	0.0424	0.5226	0.5226
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0874	0.0874
Loa Loa (eye worm)	transcriptional regulator	0.0201	0.2233	0.2206
Mycobacterium tuberculosis	Probable dehydrogenase	0.0227	0.2584	0.6224
Giardia lamblia	Kinase, PLK	0.01	0.0874	0.0874
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0	0.5
Plasmodium falciparum	thioredoxin reductase	0.0099	0.0873	0.2102
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0227	0.2584	0.6224
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0035	0.0035
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0779	1	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.0874	0.0874
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0434	0.04
Echinococcus granulosus	chromatin regulatory protein sir2	0.0779	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0434	0.0434
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0109	0.0109
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0434	0.0434
Leishmania major	silent information regulator 2, putative	0.0779	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0224	0.2548	0.2548
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.0874	0.0874
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0344	0.4151	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.0874	0.0874
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0779	1	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0779	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0434	0.0434
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0201	0.2233	0.1489
Trypanosoma brucei	polo-like protein kinase	0.01	0.0874	0.0874
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0223	0.253	0.2504
Treponema pallidum	NADH oxidase	0.0034	0	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0099	0.0873	0.0841
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0424	0.5226	0.5226
Trypanosoma cruzi	hypothetical protein, conserved	0.0224	0.2548	0.2548
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0344	0.4151	1
Loa Loa (eye worm)	transcriptional regulator	0.0779	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0099	0.0873	0.0873
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0424	0.5226	0.5226
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0344	0.4151	0.4151
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0779	1	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0201	0.2233	0.2233
Echinococcus granulosus	thioredoxin glutathione reductase	0.0099	0.0873	0.0873
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.0874	0.0874
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0	0.5
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0424	0.5226	0.5226
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0424	0.5226	0.5226
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0199	0.0199
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0035	0.0035
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0099	0.0873	0.0873
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0199	0.0199
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0201	0.2233	0.2233
Leishmania major	sir2-family protein-like protein	0.0201	0.2233	0.2233
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0424	0.5226	0.5226
Brugia malayi	Thioredoxin reductase	0.0099	0.0873	0.0873
Plasmodium vivax	hypothetical protein, conserved	0.0201	0.2233	0.5379
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0201	0.2233	0.2233
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0099	0.0873	0.2102
Brugia malayi	jmjC domain containing protein	0.01	0.0883	0.0883
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0201	0.2233	0.2233
Toxoplasma gondii	thioredoxin reductase	0.0099	0.0873	0.2102
Schistosoma mansoni	chromatin regulatory protein sir2	0.0344	0.4151	0.4151
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0434	0.0434
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0201	0.2233	0.2233
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0227	0.2584	0.6224
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0779	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0779	1	1
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0201	0.2233	0.2233
Giardia lamblia	Hypothetical protein	0.0779	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0099	0.0873	0.2102
Schistosoma mansoni	chromatin regulatory protein sir2	0.0779	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0874	0.0874
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0227	0.2584	0.7684
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0434	0.0434
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0252	0.2924	0.7043
Trypanosoma brucei	trypanothione reductase	0.0099	0.0873	0.0873
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0109	0.0109
Trypanosoma brucei	SIR2-like protein 4, putative	0.0201	0.2233	0.2233
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0344	0.4151	0.4151
Entamoeba histolytica	hypothetical protein, conserved	0.0201	0.2233	0.1489
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.0874	0.5
Toxoplasma gondii	histone deacetylase SIR2	0.0344	0.4151	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 714547