TDR Targets

Basic information

Technical information

TDR Targets ID: 715037
Name: 6-[(Z)-2-(3-bromo-4-hydroxyphenyl)ethenyl]-5- nitro-1H-pyrimidine-2,4-dione
MW: 354.113 | Formula: C12H8BrN3O5
H donors: 3 H acceptors: 7 LogP: 3.18 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nc(C=Cc2ccc(c(c2)Br)O)c(c(n1)O)[N+](=O)[O-]
InChi: 1S/C12H8BrN3O5/c13-7-5-6(2-4-9(7)17)1-3-8-10(16(20)21)11(18)15-12(19)14-8/h1-5,17H,(H2,14,15,18,19)/b3-1-
InChiKey: UCKWOQZFDRKOMP-IWQZZHSRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(Z)-2-(3-bromo-4-hydroxy-phenyl)vinyl]-5-nitro-1H-pyrimidine-2,4-dione
6-[(Z)-2-(3-bromo-4-hydroxyphenyl)vinyl]-5-nitro-1H-pyrimidine-2,4-dione
6-[(Z)-2-(3-bromo-4-hydroxy-phenyl)vinyl]-5-nitro-uracil
6-[(Z)-2-(3-bromo-4-hydroxy-phenyl)ethenyl]-5-nitro-1H-pyrimidine-2,4-dione
STK287021

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0507	0.2073
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.2175	0.6408
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.007	0.0135
Brugia malayi	Kinesin motor domain containing protein	0.0026	0.0253	0.0253
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1176	0.1738
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.2175	0.3246
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.2976	0.4442
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0507	0.0969
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0437	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0507	0.2073
Echinococcus multilocularis	muscleblind protein 1	0.0301	0.6765	1
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.2175	0.3246
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.2175	0.2175
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0842	0.1256
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0507	0.0969
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0507	0.0969
Echinococcus granulosus	muscleblind protein	0.0301	0.6765	1
Onchocerca volvulus		0.0037	0.0507	0.0252
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0318	0.6268
Echinococcus multilocularis	kinesin family 1	0.0202	0.4428	0.6546
Entamoeba histolytica	kinesin, putative	0.0026	0.0253	0.087
Schistosoma mansoni	lozenge	0.0055	0.0931	0.2447
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.007	0.0105
Echinococcus multilocularis	muscleblind protein	0.0301	0.6765	1
Onchocerca volvulus		0.0437	1	1
Loa Loa (eye worm)	hypothetical protein	0.0301	0.6765	0.6765
Schistosoma mansoni	lamin	0.0027	0.0261	0.0687
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0507	0.0507
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0318	0.5
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.007	0.5
Brugia malayi	beta-lactamase family protein	0.0037	0.0507	0.0507
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.2976	0.4442
Giardia lamblia	Kinesin-5	0.0026	0.0253	0.7404
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0026	0.0253	0.0253
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1176	0.5251
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0507	0.0756
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.6701	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.2175	0.2175
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.3355	0.6413
Toxoplasma gondii	exonuclease III APE	0.0019	0.007	0.0914
Onchocerca volvulus		0.0149	0.3168	0.2984
Toxoplasma gondii	kinesin motor domain-containing protein	0.0026	0.0253	0.3289
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0507	0.0969
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0318	0.6268
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0507	0.0507
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0437	1	1
Echinococcus granulosus	lamin	0.0027	0.0261	0.0387
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1176	0.1754
Brugia malayi	hypothetical protein	0.0149	0.3168	0.3168
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3168	0.3168
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2175	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0797	0.0797
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2175	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0797	0.0797
Echinococcus multilocularis	musashi	0.0027	0.0261	0.0387
Mycobacterium ulcerans	hypothetical protein	0.0157	0.3355	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.007	0.0105
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2175	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2175	1
Toxoplasma gondii	hypothetical protein	0.0048	0.0771	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.2976	0.4442
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0797	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0428	0.0428
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1176	0.309
Echinococcus multilocularis	Protein lozenge	0.0055	0.0931	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0797	0.0797
Brugia malayi	Muscleblind-like protein	0.0301	0.6765	0.6765
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0318	0.1175
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0318	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0318	0.1175
Schistosoma mansoni	ap endonuclease	0.0019	0.007	0.0185
Echinococcus granulosus	lamin dm0	0.0027	0.0261	0.0387
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0428	0.0428
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0507	0.0969
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.2175	0.3215
Plasmodium falciparum	kinesin-5	0.0026	0.0253	0.7979
Schistosoma mansoni	hypothetical protein	0.0034	0.0428	0.1125
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0624	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0318	0.4122
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.2175	0.4158
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0507	0.0756
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0507	0.0749
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0507	0.2073
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.007	0.0104
Onchocerca volvulus		0.0037	0.0507	0.0252
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.2175	0.2175
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0318	0.4122
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0624	0.0932
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0507	0.0969
Trichomonas vaginalis	esterase, putative	0.0037	0.0507	0.2073
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0507	0.0969
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2175	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.007	0.139
Plasmodium vivax	kinesin-5	0.0026	0.0253	0.5001
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0318	1
Echinococcus granulosus	kinesin family 1	0.0202	0.4428	0.6546
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1176	0.1754
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0507	0.1329
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.007	0.007
Brugia malayi	6-phosphofructokinase	0.0107	0.2175	0.2175
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0507	0.1332
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1176	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0261	0.0261
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0624	0.0932
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.007	0.0105
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0507	0.0507
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0507	0.2073
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.2175	0.5716
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0261	0.0261
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.2175	0.3246
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1176	0.1754
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0624	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0301	0.6765	0.6765
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0507	0.0969
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0507	0.0969
Schistosoma mansoni	hypothetical protein	0.0176	0.3805	1
Schistosoma mansoni	lamin	0.0027	0.0261	0.0687
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1176	0.1754
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.007	0.2217
Echinococcus multilocularis	lamin	0.0027	0.0261	0.0387
Schistosoma mansoni	kinesin eg-5	0.0026	0.0253	0.0666
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0507	0.0756
Onchocerca volvulus		0.0037	0.0507	0.0252
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0507	0.2073
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.2175	1
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0525	0.0776
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0318	0.5
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2175	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0261	0.0387
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0507	0.1329
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0318	1
Brugia malayi	intermediate filament protein	0.0027	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0026	0.025	0.025
Brugia malayi	6-phosphofructokinase	0.0107	0.2175	0.2175
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1176	0.1176
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0507	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0507	0.6577
Echinococcus granulosus	intermediate filament protein	0.0027	0.0261	0.0387
Brugia malayi	beta-lactamase	0.0037	0.0507	0.0507
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0318	0.4122
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.6701	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.007	0.007
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.6701	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0318	0.1175
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0507	0.1329
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.2175	0.5716
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.007	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0507	0.1329
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.6701	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0507	0.0507
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0507	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0507	0.0507
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.007	0.0104
Loa Loa (eye worm)	runx1	0.0055	0.0931	0.0931
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.2175	0.3215
Mycobacterium ulcerans	lipase LipD	0.0037	0.0507	0.1329
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0318	0.1175
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0507	0.0969
Brugia malayi	phosphofructokinase	0.0107	0.2175	0.2175
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.5231	1
Leishmania major	hypothetical protein, conserved	0.0037	0.0507	0.0756
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0525	0.0776
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1176	0.1738
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0261	0.0261
Schistosoma mansoni	ap endonuclease	0.0019	0.007	0.0185
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0261	0.0687
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0507	0.1332

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 715037