Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3367 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.126 | 0.126 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1448 | 0.1378 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0229 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0081 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.394 | 0.389 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.126 | 0.126 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0229 | 0.0679 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.3091 | 0.3091 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1442 | 0.1076 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.3091 | 0.3091 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.427 | 0.4024 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.163 | 0.1562 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1777 | 0.171 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (binding) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.