Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Aldose reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.105 | 0.0955 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0133 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Mycobacterium ulcerans | hypothetical protein | 0.0058 | 0.2915 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.105 | 1 |
Schistosoma mansoni | pol-related | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0028 | 0.0104 | 0.0104 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0058 | 0.2915 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | 0.0133 | 1 | 1 | |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.