Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Aldose reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Schistosoma mansoni | pol-related | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0133 | 1 | 1 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0133 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | 0.0133 | 1 | 1 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.105 | 0.0955 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.105 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0133 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0058 | 0.2915 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Mycobacterium ulcerans | hypothetical protein | 0.0058 | 0.2915 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.