Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aurora kinase A | 0.0072 | 0.0119 | 0.006 |
Schistosoma mansoni | gliotactin | 0.0395 | 0.1527 | 0.1476 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0062 | 0.0076 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.2335 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0077 | 0.014 | 0.0167 |
Brugia malayi | Carboxylesterase family protein | 0.0395 | 0.1527 | 0.1476 |
Loa Loa (eye worm) | AUR protein kinase | 0.0072 | 0.0119 | 0.0119 |
Onchocerca volvulus | 0.1509 | 0.6391 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0059 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Echinococcus multilocularis | acetylcholinesterase | 0.2335 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0077 | 0.014 | 0.3475 |
Loa Loa (eye worm) | hypothetical protein | 0.2335 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0077 | 0.014 | 0.3475 |
Echinococcus granulosus | carboxylesterase 5A | 0.2335 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0072 | 0.0119 | 0.006 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0112 | 0.0291 | 0.0242 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0135 | 0.0395 | 0.0568 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0395 | 0.1527 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0077 | 0.014 | 0.0127 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0149 | 0.0457 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0072 | 0.0119 | 0.1505 |
Entamoeba histolytica | cyclin, putative | 0.0077 | 0.014 | 0.2029 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0173 | 0.056 | 0.0504 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1509 | 0.6391 | 1 |
Onchocerca volvulus | 0.0395 | 0.1527 | 0.2219 | |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0072 | 0.0119 | 0.1505 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0395 | 0.1527 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2335 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0077 | 0.014 | 0.3475 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Schistosoma mansoni | kinase | 0.0064 | 0.0082 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.014 | 0.014 |
Trypanosoma brucei | polo-like protein kinase | 0.0112 | 0.0291 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2335 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0112 | 0.0291 | 0.5839 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1509 | 0.6391 | 0.6369 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0058 | 0.0059 | 0.0059 |
Onchocerca volvulus | 0.0395 | 0.1527 | 0.2219 | |
Brugia malayi | serine/threonine kinase 12 | 0.0072 | 0.0119 | 0.006 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0072 | 0.0119 | 0.1505 |
Trichomonas vaginalis | cyclins, putative | 0.0077 | 0.014 | 0.0167 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0072 | 0.0119 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1509 | 0.6391 | 0.6369 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Trichomonas vaginalis | cyclin B, putative | 0.0077 | 0.014 | 0.0167 |
Loa Loa (eye worm) | AUR protein kinase | 0.0072 | 0.0119 | 0.0119 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0149 | 0.0457 | 0.04 |
Trichomonas vaginalis | cyclins, putative | 0.0077 | 0.014 | 0.0167 |
Onchocerca volvulus | 0.1509 | 0.6391 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0059 | 0.004 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.1509 | 0.6391 | 0.6391 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0395 | 0.1527 | 0.1476 |
Trichomonas vaginalis | AGC family protein kinase | 0.0072 | 0.0119 | 0.0134 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.0059 | 0.004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Brugia malayi | Carboxylesterase family protein | 0.2335 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0072 | 0.0119 | 0.1505 |
Trichomonas vaginalis | cyclin B, putative | 0.0077 | 0.014 | 0.0167 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0058 | 0.0059 | 0.0059 |
Trichomonas vaginalis | cyclins, putative | 0.0077 | 0.014 | 0.0167 |
Echinococcus multilocularis | neuroligin | 0.0395 | 0.1527 | 0.1476 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.0291 | 0.0233 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.0291 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0077 | 0.014 | 0.3475 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0149 | 0.0457 | 0.0457 |
Trypanosoma cruzi | cyclin, putative | 0.0077 | 0.014 | 0.3475 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2335 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0072 | 0.0119 | 0.1505 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0062 | 0.0076 | 0.0067 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0072 | 0.0119 | 0.006 |
Echinococcus granulosus | acetylcholinesterase | 0.2335 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0112 | 0.0291 | 0.0233 |
Schistosoma mansoni | acetylcholinesterase | 0.0395 | 0.1527 | 0.1476 |
Echinococcus multilocularis | acetylcholinesterase | 0.2335 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.1509 | 0.6391 | 0.6369 |
Trypanosoma brucei | aurora B kinase | 0.0072 | 0.0119 | 0.2578 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.014 | 0.014 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Onchocerca volvulus | 0.0395 | 0.1527 | 0.2219 | |
Brugia malayi | serine/threonine protein kinase 6 | 0.0072 | 0.0119 | 0.006 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0395 | 0.1527 | 0.1476 |
Trichomonas vaginalis | AGC family protein kinase | 0.0072 | 0.0119 | 0.0134 |
Trichomonas vaginalis | cyclin B, putative | 0.0077 | 0.014 | 0.0167 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1509 | 0.6391 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0077 | 0.014 | 0.3475 |
Giardia lamblia | Aurora kinase | 0.0072 | 0.0119 | 0.0094 |
Loa Loa (eye worm) | carboxylesterase | 0.2335 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0119 | 0.1505 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0119 | 0.1505 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2335 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0112 | 0.0291 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0072 | 0.0119 | 0.0119 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0119 | 0.006 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0058 | 0.0059 | 0.0059 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1509 | 0.6391 | 1 |
Toxoplasma gondii | aurora kinase | 0.0072 | 0.0119 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0082 | 0.0163 | 0.2603 |
Brugia malayi | Carboxylesterase family protein | 0.0395 | 0.1527 | 0.1476 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Leishmania major | protein kinase, putative | 0.0072 | 0.0119 | 0.2578 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0395 | 0.1527 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.1527 | 0.1527 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0291 | 0.0405 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0395 | 0.1527 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0077 | 0.014 | 0.0167 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.0291 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0395 | 0.1527 | 0.1476 |
Leishmania major | cyclin | 0.0077 | 0.014 | 0.3475 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0112 | 0.0291 | 0.0233 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0072 | 0.0119 | 0.006 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0072 | 0.0119 | 0.006 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0395 | 0.1527 | 0.1476 |
Echinococcus multilocularis | aurora kinase A | 0.0072 | 0.0119 | 0.006 |
Schistosoma mansoni | kinase | 0.0149 | 0.0457 | 0.04 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0395 | 0.1527 | 0.2349 |
Loa Loa (eye worm) | carboxylesterase | 0.0395 | 0.1527 | 0.1527 |
Brugia malayi | Carboxylesterase family protein | 0.0395 | 0.1527 | 0.1476 |
Echinococcus granulosus | neuroligin | 0.0395 | 0.1527 | 0.1476 |
Giardia lamblia | Kinase, PLK | 0.0112 | 0.0291 | 0.0366 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0173 | 0.056 | 0.0504 |
Trichomonas vaginalis | AGC family protein kinase | 0.0072 | 0.0119 | 0.0134 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0112 | 0.0291 | 0.0291 |
Echinococcus multilocularis | cyclin B | 0.0077 | 0.014 | 0.0081 |
Schistosoma mansoni | cyclin B | 0.0077 | 0.014 | 0.0081 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0149 | 0.0457 | 0.04 |
Brugia malayi | Carboxylesterase family protein | 0.0395 | 0.1527 | 0.1476 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0077 | 0.014 | 0.0081 |
Echinococcus granulosus | cyclin B | 0.0077 | 0.014 | 0.0081 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0072 | 0.0119 | 0.2578 |
Onchocerca volvulus | 0.0395 | 0.1527 | 0.2219 | |
Giardia lamblia | Kinase, CDC7 | 0.1509 | 0.6391 | 1 |
Onchocerca volvulus | 0.0395 | 0.1527 | 0.2219 | |
Trichomonas vaginalis | cyclins, putative | 0.0077 | 0.014 | 0.0167 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0395 | 0.1527 | 0.2349 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0072 | 0.0119 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0072 | 0.0119 | 0.0134 |
Brugia malayi | hypothetical protein | 0.0395 | 0.1527 | 0.1476 |
Loa Loa (eye worm) | carboxylesterase | 0.0395 | 0.1527 | 0.1527 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.1509 | 0.6391 | 0.6369 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0112 | 0.0291 | 0.0233 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0395 | 0.1527 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0149 | 0.0457 | 0.04 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0077 | 0.014 | 0.0081 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0149 | 0.0457 | 0.04 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | > 100 ug ml-1 | Cytotoxic activity against MT-4 cell line | ChEMBL. | No reference |
CD50 (functional) | > 100 ug ml-1 | Cytotoxic activity against MT-4 cell line | ChEMBL. | No reference |
ID50 (functional) | = 2.5 ug ml-1 | Inhibitory concentration against HIV-1 in MT-4 cell line. | ChEMBL. | No reference |
ID50 (functional) | = 2.5 ug ml-1 | Inhibitory concentration against HIV-1 in MT-4 cell line. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.