TDR Targets

Basic information

Technical information

TDR Targets ID: 718033
Name: 3-(5-fluoro-2-methylphenyl)-1-(2-methoxy-5-me thylphenyl)urea
MW: 288.317 | Formula: C16H17FN2O2
H donors: 2 H acceptors: 1 LogP: 3.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)Nc1cc(F)ccc1C)C
InChi: 1S/C16H17FN2O2/c1-10-4-7-15(21-3)14(8-10)19-16(20)18-13-9-12(17)6-5-11(13)2/h4-9H,1-3H3,(H2,18,19,20)
InChiKey: IYQHFBBUUUSZAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(5-fluoro-2-methyl-phenyl)-1-(2-methoxy-5-methyl-phenyl)urea
IVK/0011997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0081	0.0306	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0081	0.0306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0081	0.0306	1
Plasmodium falciparum	potassium channel	0.0081	0.0306	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0046	0.0146	0.0146
Echinococcus multilocularis	twik family of potassium channels	0.0081	0.0306	0.0306
Onchocerca volvulus		0.0081	0.0306	1
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0081	0.0306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Echinococcus multilocularis	potassium channel subfamily K	0.0081	0.0306	0.0306
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0545	0.2424	0.2424
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0049	0.0159	0.0159
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Plasmodium vivax	multidomain scavenger receptor, putative	0.0016	0.0011	0.0367
Brugia malayi	hypothetical protein	0.0081	0.0306	1
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0081	0.0306	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0016	0.0008	0.0255
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0049	0.0159	0.0159
Trypanosoma cruzi	major cysteine proteinase, putative	0.0042	0.0126	0.4129
Schistosoma mansoni	lipoxygenase	0.0046	0.0146	0.0146
Onchocerca volvulus		0.0081	0.0306	1
Schistosoma mansoni	jumonji domain containing protein	0.0049	0.0159	0.0159
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0049	0.0159	0.0159
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0081	0.0306	1
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0016	0.0008	0.5
Schistosoma mansoni	rab6-interacting	0.0016	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	calcium-activated potassium channel	0.1579	0.7143	0.7143
Trypanosoma cruzi	ion transport protein, putative	0.0081	0.0306	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0016	0.0011	0.0011
Echinococcus multilocularis	potassium channel subfamily K 8	0.0081	0.0306	0.0306
Echinococcus granulosus	potassium channel subfamily K	0.0081	0.0306	0.0306
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0016	0.0008	0.0255
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.2205	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0016	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Onchocerca volvulus		0.0081	0.0306	1
Leishmania major	cathepsin L-like protease	0.0053	0.0178	0.5817
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0081	0.0306	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0011	0.0011
Loa Loa (eye worm)	TWK-28 protein	0.0081	0.0306	0.0306
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0016	0.0011	0.0011
Loa Loa (eye worm)	jmjC domain-containing protein	0.0049	0.0159	0.0159
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0081	0.0306	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0016	0.0008	0.0255
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0081	0.0306	0.0306
Loa Loa (eye worm)	uncoordinated protein 58	0.0081	0.0306	0.0306
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0178	0.5817
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0081	0.0306	1
Schistosoma mansoni	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	calcium-activated potassium channel	0.0081	0.0306	0.0306
Leishmania major	hypothetical protein, conserved	0.0081	0.0306	1
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0081	0.0306	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0081	0.0306	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0081	0.0306	1
Onchocerca volvulus		0.0081	0.0306	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0048	0.0157	0.5132
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.0108	0.0108
Schistosoma mansoni	ap endonuclease	0.0016	0.0008	0.0008
Trypanosoma cruzi	ion transport protein, putative	0.0081	0.0306	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0049	0.0159	0.0159
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus granulosus	twik family of potassium channels	0.0081	0.0306	0.0306
Plasmodium falciparum	potassium channel	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Onchocerca volvulus		0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Trichomonas vaginalis	ap endonuclease, putative	0.0016	0.0008	0.0255
Toxoplasma gondii	ion channel protein	0.0081	0.0306	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0016	0.0008	0.0255
Echinococcus granulosus	potassium channel subfamily K 8	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0081	0.0306	0.0306
Leishmania major	hypothetical protein, conserved	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	hypothetical protein	0.2205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0081	0.0306	0.0306
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0747	0.3345	0.3345
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Giardia lamblia	Hypothetical protein	0.0081	0.0306	1
Brugia malayi	Doublecortin family protein	0.0016	0.0011	0.0367
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0081	0.0306	1
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Mycobacterium ulcerans	ion transport protein	0.0081	0.0306	1
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus multilocularis	Polycystic kidney disease protein	0.0016	0.0011	0.0011
Onchocerca volvulus		0.0016	0.0011	0.0367
Schistosoma mansoni	lipoxygenase	0.0016	0.0011	0.0011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	microtubule-associated protein tau	0.0572	0.2547	0.2547
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.0306	1
Mycobacterium ulcerans	transmembrane cation transporter	0.0081	0.0306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Schistosoma mansoni	calcium-activated potassium channel	0.0081	0.0306	0.0306
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0306	1
Brugia malayi	hypothetical protein	0.0016	0.0011	0.0367
Trypanosoma cruzi	hypothetical protein, conserved	0.0081	0.0306	1
Echinococcus granulosus	RUN	0.0016	0.0011	0.0011
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0108	0.3523
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Schistosoma mansoni	loxhd1	0.0016	0.0011	0.0011
Echinococcus granulosus	twik family of potassium channels	0.0081	0.0306	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Schistosoma mansoni	polycystin 1-related	0.0016	0.0011	0.0011
Echinococcus multilocularis	RUN	0.0016	0.0011	0.0011
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0016	0.0008	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Brugia malayi	exodeoxyribonuclease III family protein	0.0016	0.0008	0.0255
Echinococcus multilocularis	lysine specific demethylase 5A	0.0049	0.0159	0.0159
Plasmodium vivax	potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0081	0.0306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Echinococcus granulosus	potassium channel subfamily K 8	0.0081	0.0306	0.0306
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0046	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Brugia malayi	jmjC domain containing protein	0.0049	0.0159	0.5201
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0016	0.0011	0.0011
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0016	0.0008	0.0255
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Leishmania major	cathepsin L-like protease	0.0053	0.0178	0.5817
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0306	1
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0016	0.0008	0.0008
Trichomonas vaginalis	ap endonuclease, putative	0.0016	0.0008	0.0255
Schistosoma mansoni	rab6-interacting	0.0016	0.0011	0.0011
Onchocerca volvulus		0.0081	0.0306	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0178	0.5817
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Leishmania major	cathepsin L-like protease	0.0053	0.0178	0.5817
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0081	0.0306	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0178	0.5817
Loa Loa (eye worm)	doublecortin family protein	0.0016	0.0011	0.0011
Echinococcus multilocularis	calcium activated potassium channel variant	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Leishmania major	potassium channel subunit-like protein	0.0081	0.0306	1
Onchocerca volvulus		0.0081	0.0306	1
Leishmania major	ion transport protein-like protein	0.0081	0.0306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Schistosoma mansoni	ap endonuclease	0.0016	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0011
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0081	0.0306	1
Loa Loa (eye worm)	TWK-7 protein	0.0081	0.0306	0.0306
Echinococcus granulosus	Polycystic kidney disease protein	0.0016	0.0011	0.0011
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0081	0.0306	1
Plasmodium falciparum	LCCL domain-containing protein	0.0016	0.0011	0.0367
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Toxoplasma gondii	exonuclease III APE	0.0016	0.0008	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0081	0.0306	1
Brugia malayi	jmjC domain containing protein	0.0049	0.0159	0.5201
Echinococcus granulosus	microtubule associated protein 2	0.0572	0.2547	0.2547
Onchocerca volvulus		0.0016	0.0011	0.0367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Echinococcus granulosus	calcium activated potassium channel variant	0.0081	0.0306	0.0306
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0011
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0016	0.0008	0.0255
Schistosoma mansoni	twik family of potassium channels-related	0.0081	0.0306	0.0306
Echinococcus multilocularis	microtubule associated protein 2	0.0572	0.2547	0.2547
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0081	0.0306	1
Leishmania major	calcium/potassium channel (CAKC), putative	0.0081	0.0306	1
Plasmodium vivax	potassium channel, putative	0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus granulosus	lysine specific demethylase 5A	0.0049	0.0159	0.0159
Echinococcus multilocularis	small conductance calcium activated potassium	0.2205	1	1
Echinococcus multilocularis	twik family of potassium channels	0.0081	0.0306	0.0306
Schistosoma mansoni	calcium-activated potassium channel	0.2205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0832	0.3735	0.3735
Onchocerca volvulus		0.0081	0.0306	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Toxoplasma gondii	ion channel protein	0.0081	0.0306	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0081	0.0306	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0081	0.0306	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0081	0.0306	0.0306
Brugia malayi	hypothetical protein	0.0016	0.0011	0.0367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707
Brugia malayi	hypothetical protein	0.0081	0.0306	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0053	0.0178	0.5817
Echinococcus multilocularis	potassium channel subfamily K 8	0.0081	0.0306	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0178	0.5707

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 718033