TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.164 | Formula: C15H11BrN2O2
H donors: 1 H acceptors: 3 LogP: 2.94 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#C/C(=C\c1cc(Br)c(c(c1)OC)O)/c1cccnc1
InChi: 1S/C15H11BrN2O2/c1-20-14-7-10(6-13(16)15(14)19)5-12(8-17)11-3-2-4-18-9-11/h2-7,9,19H,1H3/b12-5+
InChiKey: XNOGVGBAONEMEG-LFYBBSHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/ACK protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0039	0.0252	0.0252
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Trypanosoma brucei	protein kinase, putative	0.0039	0.0252	0.0145
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	tyrosine protein kinase pr2	0.0037	0.0227	0.0227
Brugia malayi	Plexin repeat family protein	0.0056	0.0545	0.075
Schistosoma mansoni	tyrosine kinase	0.0058	0.0579	0.0589
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0037	0.0227	0.0227
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0037	0.0227	0.0227
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Onchocerca volvulus		0.0048	0.0405	0.7439
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Brugia malayi	integrin-linked kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0228	0.3396	0.3456
Echinococcus multilocularis	cyclin dependent kinase 1	0.0141	0.1946	0.1946
Loa Loa (eye worm)	TK/Met protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Trypanosoma cruzi	cdc2-related kinase 1	0.0141	0.1946	1
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Trypanosoma brucei	cdc2-related kinase 1	0.0141	0.1946	1
Echinococcus granulosus	c src tyrosine kinase	0.0058	0.0579	0.0579
Echinococcus granulosus	activated cdc42 kinase 1	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0405	0.0558
Echinococcus granulosus	integrin linked protein kinase	0.0037	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	SH2 domain containing protein	0.0048	0.0405	0.0558
Brugia malayi	Tyrosine-protein kinase abl-1	0.0058	0.0579	0.0797
Entamoeba histolytica	cell division protein kinase 2, putative	0.0141	0.1946	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0037	0.0227	0.0227
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0154	0.0212
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0037	0.0227	0.0312
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0048	0.0405	0.1037
Schistosoma mansoni	tyrosine kinase	0.0058	0.0579	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Plasmodium vivax	protein kinase Crk2	0.0141	0.1946	1
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.1946	0.198
Echinococcus multilocularis	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Loa Loa (eye worm)	TK/RYK protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	protein tyrosine kinase	0.0037	0.0227	0.0227
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0461	0.7262	0.7262
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Onchocerca volvulus		0.0037	0.0227	0.4166
Echinococcus multilocularis	tyrosine protein kinase	0.0037	0.0227	0.0227
Entamoeba histolytica	protein kinase domain containing protein	0.0048	0.0398	0.0996
Schistosoma mansoni	tyrosine kinase	0.0058	0.0579	0.0589
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0227	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.0579	0.0579
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.0579	0.0579
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0037	0.0227	0.0227
Toxoplasma gondii	PAN domain-containing protein	0.0346	0.5356	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.0579	0.0579
Echinococcus multilocularis	integrin linked protein kinase	0.0037	0.0227	0.0227
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0048	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0037	0.0227	0.0227
Onchocerca volvulus		0.0037	0.0227	0.4166
Entamoeba histolytica	tyrosin kinase, putative	0.0048	0.0398	0.0996
Brugia malayi	ephrin receptor 1 precursor	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	protein tyrosine kinase	0.0037	0.0227	0.0231
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0039	0.0252	0.0145
Schistosoma mansoni	tyrosine kinase	0.0191	0.2778	0.2827
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0039	0.0252	0.0252
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Loa Loa (eye worm)	TK/FAK protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0141	0.1946	0.2679
Entamoeba histolytica	cell division protein kinase 2, putative	0.0141	0.1946	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Trichomonas vaginalis	CMGC family protein kinase	0.0141	0.1946	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0048	0.0405	0.0558
Trichomonas vaginalis	CMGC family protein kinase	0.0141	0.1946	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Onchocerca volvulus		0.0048	0.0405	0.7439
Echinococcus granulosus	plexin a4	0.0067	0.0716	0.0716
Schistosoma mansoni	tyrosine kinase	0.0191	0.2778	0.2827
Echinococcus multilocularis	activin receptor type	0.0039	0.0252	0.0252
Echinococcus multilocularis	tyrosine kinase	0.0048	0.0405	0.0405
Echinococcus multilocularis	epidermal growth factor receptor	0.0228	0.3396	0.3396
Echinococcus granulosus	tyrosine protein kinase Blk	0.0048	0.0405	0.0405
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0037	0.0227	0.0227
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0037	0.0227	0.0227
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0141	0.1946	1
Echinococcus granulosus	cyclin dependent kinase 5	0.0141	0.1946	0.1946
Schistosoma mansoni	ephrin receptor	0.0037	0.0227	0.0231
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0626	1	1
Echinococcus multilocularis	transfer RNA-Thr	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Echinococcus granulosus	tyrosine protein kinase HCK	0.0037	0.0227	0.0227
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0037	0.0227	0.0312
Schistosoma mansoni	hypothetical protein	0.0037	0.0227	0.0231
Schistosoma mansoni	tyrosine kinase	0.0228	0.3396	0.3456
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	protein-tyrosine kinase	0.0048	0.0405	0.0558
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Brugia malayi	hypothetical protein	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0405	0.0558
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0037	0.0227	0.0227
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0058	0.0579	0.0579
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Echinococcus multilocularis	epidermal growth factor receptor	0.0228	0.3396	0.3396
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Echinococcus granulosus	cyclin dependent kinase 1	0.0141	0.1946	0.1946
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0141	0.1946	0.2679
Onchocerca volvulus		0.0037	0.0227	0.4166
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.0579	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Onchocerca volvulus		0.0048	0.0405	0.7439
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0039	0.0252	0.0049
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0461	0.7262	0.7262
Echinococcus granulosus	tyrosine kinase	0.0048	0.0405	0.0405
Onchocerca volvulus	Tyrosine kinase homolog	0.0037	0.0227	0.4166
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Entamoeba histolytica	protein kinase domain containing protein	0.0039	0.0252	0.0145
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0048	0.0405	0.0405
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0037	0.0227	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0405	0.0558
Trypanosoma cruzi	cdc2-related kinase 3	0.0141	0.1946	1
Echinococcus granulosus	epidermal growth factor receptor	0.0228	0.3396	0.3396
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0037	0.0227	0.0231
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0037	0.0227	0.0227
Schistosoma mansoni	ephrin receptor	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK/INSR protein kinase	0.0461	0.7262	1
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	insulin receptor	0.0461	0.7262	0.7262
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0401	0.0408
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0141	0.1946	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0037	0.0227	0.0227
Trypanosoma brucei	cdc2-related kinase 3	0.0141	0.1946	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0037	0.0227	0.0231
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	cyclin dependent kinase	0.0141	0.1946	0.1946
Loa Loa (eye worm)	TK/ROR protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0037	0.0227	0.0227
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0037	0.0227	0.0312
Leishmania major	protein kinase, putative	0.0039	0.0252	0.0145
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.0308
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	receptor type guanylyl cyclase	0.0037	0.0227	0.0227
Onchocerca volvulus		0.0037	0.0227	0.4166
Echinococcus granulosus	ephrin type A receptor 4 A	0.0037	0.0227	0.0227
Echinococcus granulosus	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Brugia malayi	Guanylyl cyclase protein 23	0.0037	0.0227	0.0312
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0037	0.0227	0.0312
Toxoplasma gondii	PAN domain-containing protein	0.0346	0.5356	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0037	0.0227	0.0227
Brugia malayi	plexin A	0.0067	0.0716	0.0986
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	tyrosine kinase	0.0048	0.0405	0.0405
Echinococcus multilocularis	tyrosine protein kinase shark	0.0048	0.0405	0.0405
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0616	0.9826	1
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.004	0.028	0.0308
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0048	0.0405	0.0405
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.0308
Echinococcus multilocularis	plexin a4	0.0067	0.0716	0.0716
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Brugia malayi	cell division control protein 2 homolog	0.0141	0.1946	0.2679
Onchocerca volvulus		0.0037	0.0227	0.4166
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus granulosus	tyrosine protein kinase Srms	0.0048	0.0405	0.0405
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK/CSK protein kinase	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0461	0.7262	1
Schistosoma mansoni	protein kinase	0.0039	0.0252	0.0256
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.0579	0.0579
Onchocerca volvulus		0.0037	0.0227	0.4166
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	plexin A	0.0067	0.0716	0.0986
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0037	0.0227	0.4166
Echinococcus granulosus	tyrosine protein kinase	0.0037	0.0227	0.0227
Echinococcus multilocularis	protein tyrosine kinase	0.0037	0.0227	0.0227
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0037	0.0227	0.0227
Entamoeba histolytica	protein kinase, putative	0.004	0.028	0.0308
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0037	0.0227	0.0227
Echinococcus multilocularis	activated cdc42 kinase 1	0.0037	0.0227	0.0227
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Onchocerca volvulus		0.0037	0.0227	0.4166
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Brugia malayi	SRC-1	0.0058	0.0579	0.0797
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Schistosoma mansoni	tyrosine kinase	0.0228	0.3396	0.3456
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0037	0.0227	0.0227
Onchocerca volvulus		0.0037	0.0227	0.4166
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0037	0.0227	0.0227
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0141	0.1946	0.3351
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.027	0.4093	0.5636
Echinococcus multilocularis	tyrosine kinase	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0048	0.0405	0.0405
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	protein kinase	0.0039	0.0252	0.0256
Onchocerca volvulus		0.0048	0.0405	0.7439
Brugia malayi	Tyrosine-protein kinase PR2	0.0037	0.0227	0.0312
Schistosoma mansoni	hypothetical protein	0.0033	0.0154	0.0156
Schistosoma mansoni	tyrosine kinase	0.0461	0.7262	0.7391
Echinococcus multilocularis	protein kinase	0.0037	0.0227	0.0227
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0037	0.0227	0.0227
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0228	0.3396	0.3396
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0037	0.0227	0.0227
Echinococcus multilocularis	heat shock protein 70	0.0037	0.0227	0.0227
Echinococcus granulosus	tyrosine kinase	0.0037	0.0227	0.0227
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.0579	0.0579
Echinococcus multilocularis		0.0056	0.0536	0.0536
Echinococcus multilocularis	FL cytokine receptor	0.0037	0.0227	0.0227
Loa Loa (eye worm)	TK/DDR protein kinase	0.0037	0.0227	0.0312
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Brugia malayi	Receptor family ligand binding region containing protein	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0037	0.0227	0.0227
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0233	0.3475	0.4786
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0405	0.0558
Trypanosoma cruzi	cdc2-related kinase 3	0.0141	0.1946	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.0579	0.0579
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0037	0.0227	0.0227
Plasmodium falciparum	protein kinase, putative	0.0039	0.0252	0.0145
Echinococcus multilocularis	cyclin dependent kinase	0.0141	0.1946	0.1946
Giardia lamblia	Kinase, CMGC CDK	0.0141	0.1946	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0545	0.075
Schistosoma mansoni	plexin	0.0033	0.0154	0.0156
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0037	0.0227	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	Raf kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Trichomonas vaginalis	CMGC family protein kinase	0.0141	0.1946	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.0579	0.0579
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Schistosoma mansoni	tyrosine kinase	0.0461	0.7262	0.7391
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0037	0.0227	0.0227
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0037	0.0227	0.0227
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.0579	0.0579
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Trypanosoma cruzi	cdc2-related kinase 1	0.0141	0.1946	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1921	0.2645
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0037	0.0227	0.0227
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.0579	0.0579
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0227	0.0231
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0037	0.0227	0.0231
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0037	0.0227	0.0227
Echinococcus granulosus	activin receptor type	0.0039	0.0252	0.0252
Brugia malayi	hypothetical protein	0.0048	0.0405	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0405	0.0405
Echinococcus granulosus	protein kinase	0.0037	0.0227	0.0227
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0141	0.1946	0.2679
Schistosoma mansoni	tyrosine kinase	0.0058	0.0579	0.0589
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0037	0.0227	0.0227
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0039	0.0252	0.0145
Onchocerca volvulus		0.0056	0.0545	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0227	0.0312
Giardia lamblia	Kinase, CMGC CDK	0.0141	0.1946	1
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Onchocerca volvulus		0.0048	0.0405	0.7439
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0048	0.0405	0.0405
Loa Loa (eye worm)	TK/EPH protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0141	0.1946	0.1946
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0037	0.0227	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Brugia malayi	Furin-like cysteine rich region family protein	0.0228	0.3396	0.4676
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	cyclin dependent kinase 1	0.0141	0.1946	0.1946
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0405	0.0558
Echinococcus multilocularis	cyclin dependent kinase 5	0.0141	0.1946	0.1946
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0048	0.0405	0.0405
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0048	0.0405	0.0405
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Onchocerca volvulus		0.0037	0.0227	0.4166
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK/ALK protein kinase	0.0037	0.0227	0.0312
Echinococcus granulosus	natriuretic peptide receptor 1	0.0037	0.0227	0.0227
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0037	0.0227	0.0227
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0228	0.3396	0.4676
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0579	0.0579
Echinococcus granulosus	kinase suppressor of Ras 1	0.0037	0.0227	0.0227
Entamoeba histolytica	hypothetical protein	0.004	0.028	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.1946	0.198
Schistosoma mansoni	tyrosine kinase	0.0191	0.2778	0.2827
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0037	0.0227	0.0312
Echinococcus multilocularis	c src tyrosine kinase	0.0058	0.0579	0.0579
Brugia malayi	SH2 domain containing protein	0.0048	0.0405	0.0558
Echinococcus granulosus	activated cdc42 kinase 1	0.0037	0.0227	0.0227
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0037	0.0227	0.0227
Schistosoma mansoni	protein kinase	0.0039	0.0252	0.0256
Echinococcus granulosus	epidermal growth factor receptor	0.0228	0.3396	0.3396
Onchocerca volvulus		0.0048	0.0405	0.7439
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0039	0.0252	0.0145
Schistosoma mansoni	tyrosine protein kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Echinococcus multilocularis	protein kinase	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0405	0.0558
Echinococcus granulosus	insulin receptor	0.0461	0.7262	0.7262
Schistosoma mansoni	tyrosine kinase	0.0048	0.0405	0.0412
Plasmodium falciparum	protein kinase 5	0.0141	0.1946	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Brugia malayi	hypothetical protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0405	0.0558
Loa Loa (eye worm)	SRC-1	0.0058	0.0579	0.0797
Brugia malayi	C-terminal src kinase protein 1	0.0037	0.0227	0.0312
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0037	0.0227	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0405	0.0558
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0058	0.0579	0.0589
Echinococcus granulosus	tyrosine protein kinase shark	0.0048	0.0405	0.0405
Schistosoma mansoni	protein kinase	0.0037	0.0227	0.0231
Schistosoma mansoni	plexin	0.0056	0.0545	0.0554
Echinococcus granulosus	raf serine:threonine protein kinase	0.0037	0.0227	0.0227
Schistosoma mansoni	serine/threonine RGC	0.0037	0.0227	0.0231
Echinococcus multilocularis	tyrosine protein kinase csk	0.0037	0.0227	0.0227
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0227	0.0312
Echinococcus granulosus	tyrosine protein kinase Lyn	0.006	0.0604	0.0604
Schistosoma mansoni	tyrosine kinase	0.0037	0.0227	0.0231
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0141	0.1946	0.2679

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 242 uM	Inhibition of p56 Lck tyrosine kinase	ChEMBL.	No reference
IC50 (binding)	= 242 uM	Inhibition of p56 Lck tyrosine kinase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 72065