Detailed information for compound 722519

Basic information

Technical information
  • TDR Targets ID: 722519
  • Name: 3-[5-[(4-bromophenyl)methylsulfanyl]-4-ethyl- 1,2,4-triazol-3-yl]aniline
  • MW: 389.313 | Formula: C17H17BrN4S
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCc2ccc(cc2)Br)nnc1c1cccc(c1)N
  • InChi: 1S/C17H17BrN4S/c1-2-22-16(13-4-3-5-15(19)10-13)20-21-17(22)23-11-12-6-8-14(18)9-7-12/h3-10H,2,11,19H2,1H3
  • InChiKey: NELSWOPHZDUZHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-[(4-bromophenyl)methylthio]-4-ethyl-1,2,4-triazol-3-yl]aniline
  • [3-[5-[(4-bromobenzyl)thio]-4-ethyl-1,2,4-triazol-3-yl]phenyl]amine
  • STK202338
  • ZINC01112559

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0021 0.0054
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0021 0.0054
Echinococcus granulosus biogenic amine 5HT receptor 0.0135 0.061 0.1545
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0084 0.0213
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0021 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Schistosoma mansoni hypothetical protein 0.0072 0.0231 0.0585
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0021 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Onchocerca volvulus 0.0037 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.043 0.0642
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0021 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0021 0.0021
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0194 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0021 0.0032
Echinococcus multilocularis serotonin receptor 0.0135 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0021 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0717 0.0717
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0153 0.0717 0.1069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0105 0.043 0.0642
Brugia malayi ORL1-like opioid receptor 0.0037 0.0021 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0025 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0021 0.0054
Schistosoma mansoni histamine h1 receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0194 0.0194
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.123 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.093 0.2356
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0021 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0021 0.0054
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0021 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0006 0.0016
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Leishmania major mitochondrial DNA polymerase beta 0.03 0.1599 0.2356
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0021 0.0021
Brugia malayi hypothetical protein 0.0077 0.0265 0.0396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Onchocerca volvulus 0.0156 0.0737 0.1822
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0084 0.2471
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.1599 0.2356
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus hypothetical protein 0.0037 0.0021 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.093 0.093
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0021 0.0021
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0021 0.0021
Echinococcus granulosus tar DNA binding protein 0.0066 0.0194 0.0493
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.043 0.0642
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0037 0.0021 0.0054
Trypanosoma brucei C-8 sterol isomerase, putative 0.115 0.6708 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0185 0.0914 0.1362
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0021 0.0054
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi Dopamine receptor 0.0037 0.0021 0.0032
Echinococcus granulosus neuropeptide receptor 0.0037 0.0021 0.0054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0021 0.0054
Schistosoma mansoni amine GPCR 0.0037 0.0021 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0156 0.0737 0.1098
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0265 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0764 0.1935
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0194 0.0493
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0025 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0652 0.0939
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0021 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0054 0.0044
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0357 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0883 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0109 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus muscleblind protein 0.0153 0.0717 0.1817
Brugia malayi G-protein coupled receptor 0.0037 0.0021 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0054
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0265 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0084 0.0693
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0021 0.0054
Brugia malayi hypothetical protein 0.005 0.0101 0.015
Echinococcus multilocularis somatostatin receptor 0.0037 0.0021 0.0021
Brugia malayi TAR-binding protein 0.0066 0.0194 0.029
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0037 0.0094
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0021 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0243 0.0615
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0021 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0077 0.0265 0.0396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.093 0.2356
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0265 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Brugia malayi hypothetical protein 0.0038 0.0032 0.0047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0194 0.0493
Loa Loa (eye worm) hypothetical protein 0.0135 0.061 0.0909
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni biogenic amine receptor 0.0037 0.0021 0.0054
Brugia malayi Serotonin receptor 0.0037 0.0021 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.043 0.0642
Schistosoma mansoni hypothetical protein 0.0038 0.0032 0.008
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0021 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0021 0.0032
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.115 0.6708 1
Schistosoma mansoni biogenic amine receptor 0.0037 0.0021 0.0054
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0021 0.0021
Schistosoma mansoni neuropeptide receptor 0.0037 0.0021 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0652 0.0939
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0021 0.0054
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0021 0.0021
Echinococcus granulosus orexin receptor type 2 0.0037 0.0021 0.0054
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis muscleblind protein 0.0153 0.0717 0.0717
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.093 0.1386
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0054 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.093 0.2356
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0021 0.0021
Brugia malayi G-protein coupled receptor 0.0037 0.0021 0.0032
Leishmania major hypothetical protein, conserved 0.0077 0.0265 0.036
Brugia malayi G protein-coupled receptor 0.0037 0.0021 0.0032
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0152 0.0226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Brugia malayi neuropeptide F receptor 0.0037 0.0021 0.0032
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0194 0.029
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0054
Echinococcus granulosus g protein coupled receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Trypanosoma cruzi C-8 sterol isomerase, putative 0.115 0.6708 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0025 0.5
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0006 0.001
Brugia malayi beta-lactamase family protein 0.0037 0.0025 0.0037
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0021 0.0054
Echinococcus granulosus g protein coupled receptor 0.0037 0.0021 0.0054
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0021 0.0054
Schistosoma mansoni amine GPCR 0.0037 0.0021 0.0054
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0021 0.0032
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0021 0.0054
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0021 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0194 0.0493
Schistosoma mansoni opsin-like receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus sex peptide receptor 0.0037 0.0021 0.0054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0691 0.3948 0.5885
Schistosoma mansoni vesicular acetylcholine transporter 0.0691 0.3948 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni adenoreceptor 0.0037 0.0021 0.0054
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0764 0.1139
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0021 0.0054
Schistosoma mansoni amine GPCR 0.0037 0.0021 0.0054
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0025 0.0062
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0021 0.0054
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi Dopamine receptor protein 1 0.0037 0.0021 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.05 0.1268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Brugia malayi GnHR receptor homolog 0.0037 0.0021 0.0032
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi vesicular acetylcholine transporter unc-17 0.0691 0.3948 0.5885
Schistosoma mansoni amine GPCR 0.0037 0.0021 0.0054
Schistosoma mansoni lipoxygenase 0.0117 0.05 0.1268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Brugia malayi hypothetical protein 0.0156 0.0737 0.1098
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0021 0.0054
Brugia malayi AKH receptor 0.0037 0.0021 0.0032
Echinococcus multilocularis serotonin receptor 0.0135 0.061 0.061
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0021 0.0054
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0084 0.0693
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.006 0.5
Echinococcus granulosus vesicular acetylcholine transporter 0.0691 0.3948 1
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0153 0.0717 0.1069
Schistosoma mansoni amine GPCR 0.0037 0.0021 0.0054
Brugia malayi larval opioid receptor 0.0037 0.0021 0.0032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0049 0.0092 0.0137
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0021 0.0032
Mycobacterium leprae Probable lipase LipE 0.0037 0.0025 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.0737 0.1867
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.093 0.2356
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0006 0.0016
Schistosoma mansoni opsin-like receptor 0.0037 0.0021 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.093 0.1386
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0021 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.093 0.2356
Brugia malayi jmjC domain containing protein 0.0093 0.0357 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0021 0.0054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0021 0.0054
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0009 0.0023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0764 0.0764
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0021 0.0054
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0021 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1599 0.2356
Onchocerca volvulus 0.0037 0.0025 0.0009
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0021 0.0021
Schistosoma mansoni neuropeptide receptor 0.0037 0.0021 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Brugia malayi Melatonin receptor type 1A 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0231 0.0345
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0265 0.036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0025 0.0037
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0021 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0021 0.0021
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Echinococcus granulosus serotonin receptor 0.0037 0.0021 0.0054
Echinococcus granulosus somatostatin receptor 0.0037 0.0021 0.0054
Onchocerca volvulus 0.0037 0.0025 0.0009
Leishmania major C-8 sterol isomerase-like protein 0.115 0.6708 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0231 0.0345
Brugia malayi hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Brugia malayi RNA binding protein 0.0066 0.0194 0.029
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0054
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi jmjC domain containing protein 0.0034 0.0006 0.001
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0021 0.0032
Brugia malayi beta-lactamase 0.0037 0.0025 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0021 0.0032
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0021 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0135 0.061 0.1545
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis sex peptide receptor 0.0037 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0021 0.0054
Echinococcus granulosus neuropeptide receptor 0.0037 0.0021 0.0054
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0185 0.0914 0.1362
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0135 0.061 0.0909
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0021 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0006 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0006 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0021 0.0032
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0691 0.3948 1
Echinococcus granulosus g protein coupled receptor 0.0037 0.0021 0.0054
Mycobacterium ulcerans hypothetical protein 0.0158 0.0748 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0021 0.0054
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0194 0.0493
Schistosoma mansoni neuropeptide receptor 0.0037 0.0021 0.0054
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0265 0.036
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0021 0.0032
Brugia malayi Serotonin receptor 0.0037 0.0021 0.0032
Schistosoma mansoni myosin xvIII 0.0037 0.0021 0.0054
Echinococcus granulosus fmrfamide receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0021 0.0032
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0021 0.0032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0054 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0021 0.0054
Echinococcus granulosus allatostatin A receptor 0.0037 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) RNA binding protein 0.0066 0.0194 0.029
Brugia malayi neuropeptide F receptor 0.0037 0.0021 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0032 0.008
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0037 0.0037
Schistosoma mansoni neuropeptide receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0021 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi Dopamine receptor protein 2 0.0037 0.0021 0.0032
Toxoplasma gondii hypothetical protein 0.0048 0.0091 0.2755
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0194 0.0493
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Brugia malayi ERG2 and Sigma1 receptor like protein 0.115 0.6708 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0588 0.3331 0.4966
Brugia malayi RE15519p 0.0037 0.0021 0.0032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0054 0.0044
Brugia malayi Muscleblind-like protein 0.0153 0.0717 0.1069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Brugia malayi beta-lactamase family protein 0.0037 0.0025 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0021 0.0054
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0652 0.0939
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.05 0.05
Brugia malayi sulfakinin receptor protein 0.0037 0.0021 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0021 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0748 0.6002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0357 0.0357
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0021 0.0021
Loa Loa (eye worm) beta-lactamase 0.0037 0.0025 0.0037
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.006 1
Loa Loa (eye worm) acetyltransferase 0.016 0.0764 0.1139
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0021 0.0032
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0021 0.0054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0021 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0025 0.0062
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0054
Schistosoma mansoni opsin-like receptor 0.0037 0.0021 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.093 0.093
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0084 0.2471
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0194 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0084 0.2471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Schistosoma mansoni lipoxygenase 0.0081 0.029 0.0734
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0021 0.0021
Brugia malayi putative neuropeptide receptor 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0265 0.036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0032
Echinococcus multilocularis vesicular acetylcholine transporter 0.0691 0.3948 0.3948
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1599 0.2356
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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