Detailed information for compound 728353

Basic information

Technical information
  • TDR Targets ID: 728353
  • Name: 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]s ulfanyl]-N-phenylacetamide
  • MW: 345.803 | Formula: C16H12ClN3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CSc1nnc(o1)c1cccc(c1)Cl
  • InChi: 1S/C16H12ClN3O2S/c17-12-6-4-5-11(9-12)15-19-20-16(22-15)23-10-14(21)18-13-7-2-1-3-8-13/h1-9H,10H2,(H,18,21)
  • InChiKey: ASGGGFGAIZUNRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-phenyl-acetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-phenylacetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-phenyl-acetamide
  • 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-phenyl-ethanamide
  • STK226200
  • CBKinase1_008667
  • CBKinase1_021067
  • ZINC01111199

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0846 0.5489
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0079 0.0846 0.2331
Echinococcus granulosus GPCR family 2 0.0019 0.0108 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0846 0.0846
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0299 0.3548 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0846 0.0944
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0172 0.1981 0.5553
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0846 1
Onchocerca volvulus 0.0299 0.3548 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.0998
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0846 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0607 0.1655
Onchocerca volvulus 0.0172 0.1981 0.5553
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0185 0.0456
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0108 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0024 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0108 0.0093
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 1
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0846 0.0944
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0108 0.0093
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0301 0.1194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0607 0.1655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0108 0.0236
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0024 0.0024
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0881 0.0868
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0024 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0119 0.0105
Brugia malayi hypothetical protein 0.0172 0.1981 0.5553
Mycobacterium ulcerans beta-lactamase 0.0079 0.0846 0.9328
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0222 0.1356
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0185 0.0909
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0351 0.0337
Loa Loa (eye worm) hypothetical protein 0.0128 0.1443 0.4026
Loa Loa (eye worm) hypothetical protein 0.006 0.0607 0.1655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0437 0.0437
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0846 0.0944
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0299 0.3548 1
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0351 0.0337
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0185 0.0867
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0437 0.0423
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0535 0.4744
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0024 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.0108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0119 0.1352
Loa Loa (eye worm) hypothetical protein 0.0128 0.1443 0.4026
Brugia malayi beta-lactamase 0.0079 0.0846 0.2331
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0041 0.0376 0.0376
Onchocerca volvulus 0.0299 0.3548 1
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0535 0.0521
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0024 0.001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 1
Onchocerca volvulus 0.0079 0.0846 0.2331
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0024 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0846 0.2331
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0024 0.001
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0024 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0185 0.2101
Onchocerca volvulus 0.0172 0.1981 0.5553
Brugia malayi beta-lactamase family protein 0.0079 0.0846 0.2331
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0351 0.319
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0222 0.2524
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0881 1
Schistosoma mansoni hypothetical protein 0.0019 0.0108 0.0108
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0024 0.001
Toxoplasma gondii ABC1 family protein 0.0079 0.0846 0.9595
Onchocerca volvulus 0.0299 0.3548 1
Echinococcus granulosus neuropeptide receptor A26 0.0489 0.5878 0.5872
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0846 0.0944
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0024 0.001
Mycobacterium tuberculosis Conserved protein 0.0079 0.0846 0.0944
Mycobacterium ulcerans lipase LipD 0.0079 0.0846 0.9328
Leishmania major hypothetical protein, conserved 0.0025 0.0185 0.0909
Leishmania major hypothetical protein, conserved 0.0079 0.0846 1
Echinococcus granulosus bloom syndrome protein 0.002 0.0119 0.0105
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0351 0.319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Conserved protein 0.0079 0.0846 0.0944
Loa Loa (eye worm) hypothetical protein 0.0128 0.1443 0.4026
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0024 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0108 0.0236
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0846 0.9459
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0351 0.1751
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0846 0.0832
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0351 0.319
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0351 0.1751
Entamoeba histolytica recQ family helicase, putative 0.002 0.0119 0.3395
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0119 0.0269
Onchocerca volvulus 0.0128 0.1443 0.4026
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0846 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0607 0.1655
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.0172 0.1981 0.5553
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0119 0.0105
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0024 0.001
Onchocerca volvulus 0.0299 0.3548 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0082 0.0881 0.2432
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0535 0.0521
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0119 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0846 0.0944
Toxoplasma gondii hypothetical protein 0.0028 0.0222 0.2524
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.1981 0.5553
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0846 0.9595
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0437 0.1171
Loa Loa (eye worm) inositol-1 0.0039 0.0351 0.0927
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0024 0.001
Mycobacterium ulcerans hypothetical protein 0.0079 0.0846 0.9328
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0846 0.9328
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0119 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0437 0.0423
Mycobacterium leprae Probable lipase LipE 0.0079 0.0846 0.9459
Schistosoma mansoni coup transcription factor 0.0012 0.0024 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0108 0.0236
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0846 0.0944
Brugia malayi LBP/BPI 0.0128 0.1443 0.4026
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0535 0.0405
Loa Loa (eye worm) hypothetical protein 0.0172 0.1981 0.5553
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0119 0.0269
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0535 0.0405
Trichomonas vaginalis esterase, putative 0.0079 0.0846 0.5489
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.1443 1
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Onchocerca volvulus 0.0299 0.3548 1
Brugia malayi hypothetical protein 0.0128 0.1443 0.4026
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0172 0.1981 0.5553
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0024 0.0024
Schistosoma mansoni inositol monophosphatase 0.0039 0.0351 0.0351
Brugia malayi Probable ClpP-like protease 0.0082 0.0881 0.2432
Schistosoma mansoni microtubule-associated protein tau 0.0825 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0185 0.2101
Loa Loa (eye worm) hypothetical protein 0.0172 0.1981 0.5553
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0846 0.5489
Onchocerca volvulus 0.0299 0.3548 1
Brugia malayi hypothetical protein 0.0025 0.0185 0.0456
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0024 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0119 0.1352
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0881 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0846 0.0832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0024 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0846 0.5489
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0437 0.0437
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0846 0.5489
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0185 0.0909
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0351 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0108 0.0093
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0376 0.0998
Brugia malayi Inositol-1 0.0039 0.0351 0.0927
Echinococcus granulosus neuropeptide s receptor 0.0489 0.5878 0.5872
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0437 0.0437
Loa Loa (eye worm) RecQ helicase 0.002 0.0119 0.0269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0437 0.0423
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0108 0.0093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0024 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0024 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0024 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0846 0.0846
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0024 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0024 0.001
Echinococcus multilocularis bloom syndrome protein 0.002 0.0119 0.0105
Schistosoma mansoni DNA helicase recq5 0.002 0.0119 0.0119
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0024 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0881 0.5
Brugia malayi hypothetical protein 0.0016 0.0076 0.0145
Loa Loa (eye worm) hypothetical protein 0.0172 0.1981 0.5553
Onchocerca volvulus 0.0299 0.3548 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0119 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0024 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0351 0.1751
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0299 0.3548 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0172 0.1981 0.5553
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0351 0.319
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0881 0.0881
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0846 0.9328
Loa Loa (eye worm) hypothetical protein 0.0299 0.3548 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0185 0.0867
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0846 0.2331
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0172 0.1981 0.5553
Brugia malayi beta-lactamase family protein 0.0079 0.0846 0.2331
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0172 0.1981 0.5553
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.9819 0.9819
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0881 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0119 0.0269
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0881 0.0868
Loa Loa (eye worm) hypothetical protein 0.0079 0.0846 0.2331
Brugia malayi hypothetical protein 0.0172 0.1981 0.5553
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0846 0.5489
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0846 0.0944
Echinococcus multilocularis neuropeptide s receptor 0.0489 0.5878 0.5872
Loa Loa (eye worm) hypothetical protein 0.0128 0.1443 0.4026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0881 1
Onchocerca volvulus 0.0079 0.0846 0.2331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0024 0.001
Onchocerca volvulus 0.0299 0.3548 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0119 0.0119
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0351 0.3982
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0437 0.1171
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0299 0.3548 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0846 0.0944
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0024 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0437 0.0423
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0185 0.0909
Echinococcus multilocularis microtubule associated protein 2 0.0825 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0489 0.5878 0.5872
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0119 0.0105
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0505 0.6071 1
Loa Loa (eye worm) beta-lactamase 0.0079 0.0846 0.2331
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0024 0.0024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.